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epithelial cells

hAECs and Their Exosomes Improve Cardiac Function after Acute Myocardial Infarction in Rats

[Aging] Researchers cultured human amniotic epithelial cells (hAECs) and extracted exosomes from culture supernatants. They established a stable acute myocardial infarction model in rats and treated them with hAECs, exosomes, or PBS.

Dynamic Patterns of DNA Methylation in the Normal Prostate Epithelial Differentiation Program Are Targets of Aberrant Methylation in Prostate Cancer

[Scientific Reports] The authors utilized the established non-malignant HPr1-AR prostate epithelial cell model that upon androgen exposure committed to a luminal cell differentiation trajectory from that of a basal-like state.

Inhibition of Nuclear Factor (Erythroid-Derived 2)-like 2 Promotes Hepatic Progenitor Cell Activation and Differentiation

[NPJ Regenerative Medicine] Researchers analyzed the oxidative damage in models of liver injury characterized by biliary epithelial cells/hepatic progenitor cells (HPCs) activation and defined the impact of redox balance perturbation on HPC fate. They then identified Nuclear factor (erythroid-derived 2)-like 2 as the main transcription factor involved in the activation of HPCs.

Mesenchymal Stem Cell-Derived Microvesicles Improve Intestinal Barrier Function by Restoring Mitochondrial Dynamic Balance in Sepsis Rats

[Stem Cell Research & Therapy] Cecal ligation and puncture-induced sepsis rats and lipopolysaccharide-stimulated intestinal epithelial cells to investigate the effect of mesenchymal stem cell-derived microvesicles on intestinal barrier dysfunction.

Cytosolic Replication in Epithelial Cells Fuels Intestinal Expansion and Chronic Fecal Shedding of Salmonella typhimurium

[Cell Host & Microbe] In the intestine, Salmonella enterica serovar Typhimurium actively invaded intestinal epithelial cells and survived in the Salmonella-containing vacuole and the cell cytosol.

Synergistic Cycles of Protease Activity and Inflammation via PPARÎł Degradation in Chronic Obstructive Pulmonary Disease

[Experimental and Molecular Medicine] Scientists evaluated the effect of neutrophil elastase on lipopolysaccharide - induced interleukin 8 production and determined the molecular mechanism in human bronchial epithelial cells.

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