The CCL5/CCR5 Axis in Cancer Progression

Researchers summarize current knowledge on the role of the C-C chemokine ligand 5/C-C chemokine receptor type 5 (CCL5/CCR5) axis in cancer.
[Cancers]
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Genetic Reduction of the Extracellular Matrix Protein Versican Attenuates Inflammatory Cell Infiltration and Improves Contractile Function in Dystrophic mdx Diaphragm Muscles

Versican reduction improved the ex vivo strength and endurance of diaphragm muscle strips. These changes in diaphragm contractile properties in mdx-hdf mice were associated with decreased monocyte and macrophage infiltration and a reduction in the proportion of fibres expressing the slow type I myosin heavy chain isoform
[Scientific Reports]
McRae, N. L., Addinsall, A. B., Howlett, K. F., McNeill, B., McCulloch, D. R., & Stupka, N. (2020). Genetic reduction of the extracellular matrix protein versican attenuates inflammatory cell infiltration and improves contractile function in dystrophic mdx diaphragm muscles. Scientific Reports, 10(1), 11080. https://doi.org/10.1038/s41598-020-67464-x Cite
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Laminin-511-E8 Promotes Efficient In Vitro Expansion of Human Limbal Melanocytes

Scientists established a protocol for the efficient isolation and cultivation of pure populations of human limbal melanocytes, which could be expanded at high yield by using recombinant laminin-511-E8 as culture substrate.
[Scientific Reports]
Polisetti, N., Gießl, A., Li, S., Sorokin, L., Kruse, F. E., & Schlötzer-Schrehardt, U. (2020). Laminin-511-E8 promotes efficient in vitro expansion of human limbal melanocytes. Scientific Reports, 10(1), 11074. https://doi.org/10.1038/s41598-020-68120-0 Cite
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Static Magnetic Field–Enhanced Osteogenic Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells via Matrix Vesicle Secretion

Wharton’s jelly mesenchymal stem cells were treated with a 0.4-T static magnetic field. The cell viability was tested using the MTT assay.
[International Journal of Radiation Biology]
Chang, C.-Y., Lew, W.-Z., Feng, S.-W., Wu, C.-L., Wang, H.-H., Hsieh, S.-C., & Huang, H.-M. (2020). Static magnetic field–enhanced osteogenic differentiation of human umbilical cord-derived mesenchymal stem cells via matrix vesicle secretion. International Journal of Radiation Biology, 0(ja), 1–27. https://doi.org/10.1080/09553002.2020.1787545 Cite
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Control of Fibroblast Shape in Sequentially Formed 3D Hybrid Hydrogels Regulates Cellular Responses to Microenvironmental Cues

Investigators presented a hydrogel-based platform to control cell shape in three dimensions by using sequentially formed hybrid hydrogels consisting of collagen and alginate.
[NPG Asia Materials]
Liu, H., Wu, M., Jia, Y., Niu, L., Huang, G., & Xu, F. (2020). Control of fibroblast shape in sequentially formed 3D hybrid hydrogels regulates cellular responses to microenvironmental cues. NPG Asia Materials, 12(1), 1–12. https://doi.org/10.1038/s41427-020-0226-7 Cite
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Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination

The authors review the latest literature describing the structure of the mammary gland and the breast cancer microenvironment (BCM) and summarize the influence of epithelial-mesenchymal transition and autophagy in breast cancer dissemination.
[Cancers]
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Extracellular Matrix Dynamics in Vascular Remodeling

The authors summarize how extracellular matrix (ECM) dynamics control vascular remodeling, and further indicate potential diagnostic biomarkers and therapeutic targets in the ECM for corresponding vascular diseases.
[American Journal of Physiology-Cell Physiology]
Extracellular Matrix Dynamics in Vascular Remodeling | American Journal of Physiology-Cell Physiology. (n.d.). Retrieved June 30, 2020, from https://journals.physiology.org/doi/abs/10.1152/ajpcell.00147.2020 Cite
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Identification of the SRC-Family Tyrosine Kinase HCK as a Therapeutic Target in Mantle Cell Lymphoma

Investigators showed that the SRC-family tyrosine kinase hematopoietic cell kinase (HCK), which is primarily expressed in the hematopoietic lineage but not in mature B cells, was aberrantly expressed in mantle cell lymphoma (MCL), and that high expression of HCK was associated with inferior prognosis of MCL patients.
[Leukemia]
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Bioactive‐Tissue‐Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing

A decellularized cardiac extracellular matrix‐based nanocomposite hydrogel was developed to provide superior mechanical stability, catheter injectability, retrievability, antibacterial properties, and biological activity to prevent recanalization.
[Advanced Materials]
Hu, J., Altun, I., Zhang, Z., Albadawi, H., Salomao, M. A., Mayer, J. L., Hemachandra, L. P. M. P., Rehman, S., & Oklu, R. (n.d.). Bioactive-Tissue-Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing. Advanced Materials, n/a(n/a), 2002611. https://doi.org/10.1002/adma.202002611 Cite
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A Scaffold Laden with Mesenchymal Stem Cell-Derived Exosomes for Promoting Endometrium Regeneration and Fertility Restoration through Macrophage Immunomodulation

A novel and viable cell-free therapeutic strategy by umbilical cord-MSC-derived exosomes was proposed.
[Acta Biomaterialia]
Xin, L., Lin, X., Zhou, F., Li, C., Wang, X., Yu, H., … Zhang, S. (2020). A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2020.06.029 Cite
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Switch of Macrophage Fusion Competency by 3D Matrices

Scientists introduced a collagen-based 3D matrix to embed Raw264.7 cell line and primary rat bone marrow-derived macrophages.
[Scientific Reports]
Fang, J. Y., Yang, Z., & Han, B. (2020). Switch of macrophage fusion competency by 3D matrices. Scientific Reports, 10(1), 10348. https://doi.org/10.1038/s41598-020-67056-9 Cite
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