extracellular matrix

[Nature Communications] Investigators reported that the neuronal ECM could be remodeled frequently through mechanisms that involved endocytosis and recycling of ECM proteins.

[Laboratory Investigation] Investigators elucidated the role of miR-200c in cholestasis-induced biliary liver fibrosis and cholangiocyte activation, identifying sestrin 1 (SESN1) as a target of miR-200c.

[Cell Death & Disease] Scientists demonstrated that stiffness contributed to mechanosignal transduction in hepatic stellate cells, which promoted hepatocellular carcinoma cells growth and metastasis through secretion of FGF2.

[eLife] Researchers indicate that microtubules (MTs) stability in the β-cell population was heterogenous, and that glucose-stimulated insulin secretion was suppressed in cells with highly stable MTs.

[Communications Biology] Co-cultured using a magnetic spheroid formation approach, conditionally immortalised human podocytes and glomerular endothelial cells deposited mature, organized isoforms of collagen IV and Laminin.

[Scientific Reports] Researchers obtained and analyzed PCBP1-knockdown RNA-seq data and eCLIP-seq data of PCBP1 in HepG2 cells and found that PCBP1 widely regulated the alternative splicing and expression of genes enriched in cancer-related pathways, including extracellular matrix, cell adhesion, small molecule metabolic process and apoptosis.