Researchers summarize current knowledge on the role of the C-C chemokine ligand 5/C-C chemokine receptor type 5 (CCL5/CCR5) axis in cancer.
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Versican reduction improved the ex vivo strength and endurance of diaphragm muscle strips. These changes in diaphragm contractile properties in mdx-hdf mice were associated with decreased monocyte and macrophage infiltration and a reduction in the proportion of fibres expressing the slow type I myosin heavy chain isoform
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McRae, N. L., Addinsall, A. B., Howlett, K. F., McNeill, B., McCulloch, D. R., & Stupka, N. (2020). Genetic reduction of the extracellular matrix protein versican attenuates inflammatory cell infiltration and improves contractile function in dystrophic mdx diaphragm muscles. Scientific Reports, 10(1), 11080. https://doi.org/10.1038/s41598-020-67464-x Cite
Scientists established a protocol for the efficient isolation and cultivation of pure populations of human limbal melanocytes, which could be expanded at high yield by using recombinant laminin-511-E8 as culture substrate.
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Wharton’s jelly mesenchymal stem cells were treated with a 0.4-T static magnetic field. The cell viability was tested using the MTT assay.
[International Journal of Radiation Biology]
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Chang, C.-Y., Lew, W.-Z., Feng, S.-W., Wu, C.-L., Wang, H.-H., Hsieh, S.-C., & Huang, H.-M. (2020). Static magnetic field–enhanced osteogenic differentiation of human umbilical cord-derived mesenchymal stem cells via matrix vesicle secretion. International Journal of Radiation Biology, 0(ja), 1–27. https://doi.org/10.1080/09553002.2020.1787545 Cite
Investigators presented a hydrogel-based platform to control cell shape in three dimensions by using sequentially formed hybrid hydrogels consisting of collagen and alginate.
[NPG Asia Materials]
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The authors review the latest literature describing the structure of the mammary gland and the breast cancer microenvironment (BCM) and summarize the influence of epithelial-mesenchymal transition and autophagy in breast cancer dissemination.
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The authors summarize how extracellular matrix (ECM) dynamics control vascular remodeling, and further indicate potential diagnostic biomarkers and therapeutic targets in the ECM for corresponding vascular diseases.
[American Journal of Physiology-Cell Physiology]
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Extracellular Matrix Dynamics in Vascular Remodeling | American Journal of Physiology-Cell Physiology. (n.d.). Retrieved June 30, 2020, from https://journals.physiology.org/doi/abs/10.1152/ajpcell.00147.2020 Cite
Investigators showed that the SRC-family tyrosine kinase hematopoietic cell kinase (HCK), which is primarily expressed in the hematopoietic lineage but not in mature B cells, was aberrantly expressed in mantle cell lymphoma (MCL), and that high expression of HCK was associated with inferior prognosis of MCL patients.
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A decellularized cardiac extracellular matrix‐based nanocomposite hydrogel was developed to provide superior mechanical stability, catheter injectability, retrievability, antibacterial properties, and biological activity to prevent recanalization.
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Hu, J., Altun, I., Zhang, Z., Albadawi, H., Salomao, M. A., Mayer, J. L., Hemachandra, L. P. M. P., Rehman, S., & Oklu, R. (n.d.). Bioactive-Tissue-Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing. Advanced Materials, n/a(n/a), 2002611. https://doi.org/10.1002/adma.202002611 Cite
A novel and viable cell-free therapeutic strategy by umbilical cord-MSC-derived exosomes was proposed.
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Xin, L., Lin, X., Zhou, F., Li, C., Wang, X., Yu, H., … Zhang, S. (2020). A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2020.06.029 Cite
Scientists introduced a collagen-based 3D matrix to embed Raw264.7 cell line and primary rat bone marrow-derived macrophages.