extracellular matrix

[Nature] The authors presented a chip-based culture system that enabled self-organization of micropatterned stem cells into precise three-dimensional cell-fate patterns and organ shapes. They recreated neural tube folding from human stem cells in a dish.

[Scientific Reports] Scientists investigated the possibility that periostin secreted by fibroblasts derived from idiopathic pulmonary fibrosis lung might have affected proliferation of non-small cell lung cancer cells.

[Gastroenterology] Scientists proposed that IL-13 decreased TSPAN12, likely contributing to the chronicity of eosinophilic esophagitis by promoting tissue remodeling through fibroblast-endothelial cell crosstalk.

[ACS Biomaterials Science & Engineering] To overcome the limitation characteristic of pure ECM hydrogels, researchers presented a composite material containing alginate, a seaweed-derived polysaccharide, and gelatin, denatured collagen, as rheological modifiers which imparted mechanical integrity to the biologically active decellularized ECM

[Cancer Research] Investigators described a chemotherapy-induced, host-mediated mechanism that promoted remodeling of the ECM, ultimately facilitating cancer cell seeding and metastasis.

[Cell Metabolism] The authors showed that skeletal muscle of type 2 diabetes mellitus patients exhibited degenerative remodeling of the ECM that was associated with a selective increase of a subpopulation of fibro-adipogenic progenitors (FAPs) marked by expression of THY1 (CD90)—the FAPCD90+.