fibroblasts

[Nature Communications] Researchers profiled distal lung samples from healthy human donors across the lifespan and revealed the transcriptional and structural features of fibrosis and associated functional impairment in normal lung aging.

[Scientific Reports] Scientists developed a culture system regulating culture temperature immediately and accurately by employing metallic culture vessels. Michigan Cancer Foundation-7 cells and normal human dermal fibroblasts were used for models of cancer and normal cells.

[Laboratory Investigation] Researchers demonstrated marked and synergistic upregulation of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 4 by IL-1α, TNF-α and TGF-β in osteoarthritis (OA) synovial fibroblasts, and suggested that concurrent therapy with an anti-TNF-α drug and inhibitor may be useful for prevention against aggrecan degradation in OA.

[Nature Communications] The authors investigated mature human hypertrophic scars and developing scars in mice at single cell resolution. They delineated the genetic landscape of hypertrophic scars and presented insights into mechanisms involved in hypertrophic scar formation.

[Matrix Biology] Investigators indicated that elevated TGFβ signaling led to an attenuated response to growth factors, which contributed to impaired dermal wound healing in recessive dystrophic epidermolysis bullosa.

[Journal of Translational Medicine] Scientists discuss current literature on the effects of radiation on cancer-associated fibroblasts (CAFs) and the influence that CAFs have on radiotherapy outcomes, and summarize present knowledge on the transformed cellular crosstalk between CAFs and immune cells after radiation.