glioblastoma

[Journal of Histochemistry & Cytochemistry] Scientists review recent literature on energy production in glioblastoma stem cells and leukemic stem cells versus their normal counterparts, neural stem cells and hematopoietic stem cells, respectively.

[Translational Oncology] Scientists created organoid microarrays and visualized bulk and spatial differences in cell proliferation using immunohistochemistry staining, and cell cycle analysis by flow cytometry paired with 3D regional labeling.

[Scientific Reports] Investigators explored breast cancer and glioblastoma multiforme cell lines MDA-MB-321 and U87-MG, and evaluated the impact of hyaluronan on tumor promoting features of bone marrow-derived mesenchymal stem cells, and their interaction with tumor cells.

[npj Precision Oncology] Researchers isolated patient-derived glioblastoma cells showing high GD2 antigen expression representing a potential target for CAR T strategy.

[Oncogenesis] A mutation in isocitrate dehydrogenase 1 was found to suppress the transforming growth factor-beta signaling pathway and E2F4 interacted with Smad3 to inhibit expression of mesenchymal markers.

[Cell Death Discovery] The authors screened various collagen types and observed that the type V collagen α1 chain (COL5A1) gene played a pivotal role in glioblastoma. They investigated the involvement of COL5A1 in ECM remodeling and the regulation of actin filaments in the metastasis of GBM.