glioblastoma

[Acta Neuropathologica] Researchers reported biological features of invasive growth accompanying tumor progression and invasion based on associated metabolic and transcriptomic changes observed in patient derived orthotopic xenografts in the mouse and the corresponding patients’ tumors.

[British Journal of Cancer] Researchers discuss the immunostimulatory and immunosuppressive roles of interleukin-10 (IL-10) in the glioblastoma tumour microenvironment while considering IL-10-targeted treatment strategies.

[Stem Cell Reviews and Reports] Scientists summarize findings to advocate the reactivation of tumor suppressors p53 and PTEN in glioblastoma treatment and use MSCs as a “Trojan horse” to carry oncolytic viral cargo to disseminated tumor beds.

[Cell Reports] Researchers identified a human glioblastoma subset characterized by ERBB3 overexpression and nuclear accumulation.

[Aging-Us] The authors silenced two autophagy related genes -either Beclin1 or ATG5- by shRNA and they explored the ensuing consequences on CSCs markers’ expression and functionalities.

[Scientific Reports] In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, researchers assessed the anti-tumor effects of sonodynamic therapy with a COX-2 inhibitor, celecoxib.