glioblastoma

[Cell Research] Researchers uncovered that pericytes potentiated DNA damage repair in glioblastoma cells residing in the perivascular niche, which induced temozolomide chemoresistance.

[Scientific Reports] Researchers hypothesized that activating transcription factor 4 was essential for the adaptation of human glioblastoma cells to the conditions of the tumor microenvironment and contributed to therapy resistance against chemotherapy.

[International Journal of Molecular Sciences] The authors review the available literature on plasma circulating tumor cells, cell-free tumors, circulating cell-free microRNAs, and circulating extracellular vesicles for the diagnosis and monitoring of brain tumor.

[Science Translational Medicine] Scientists reported that DNA-dependent protein kinase (DNA-PK) governed SOX2 stability through phosphorylation, resulting in glioma stem cell maintenance.

[Journal of Clinical Investigation] Tumor cell SLIT2 knockdown inhibited macrophage invasion and promoted a cytotoxic gene expression profile, which improved tumor vessel function and enhanced efficacy of chemotherapy and immunotherapy.

[Nature Communications] Investigators discovered that prohibitin (PHB) specifically regulates mitochondrial ROS production in glioma stem-like cells (GSCs) and facilitates GSC radiotherapeutic resistance.