glioblastoma

[Journal of Clinical Investigation] The author interrogated the role of Adenosine-to-Inosine RNA editing mediated by adenosine deaminase acting on RNA (ADAR) in glioblastoma stem cells (GSCs) and found that both ADAR1 and global RNA editomes were elevated in GSCs compared to normal neural stem cells.

[Cancer Research] Investigators showed that LAMP2A expression was enriched in patient-derived glioblastoma stem cells (GSC), and its depletion diminished GSC-mediated tumorigenic activities.

[Angiogenesis] Scientists dissected vascular cues influencing glioblastoma stem cells (GSCs) gene expression and function to perfusion-based vascular cues, as well as to those requiring direct GSC-endothelial cell contacts.

[Signal Transduction and Targeted Therapy] EPHA2 might contribute to platelet-derived growth subunit A (PDGFA) signaling transduction in combination with platelet-derived growth receptor α (PDGFRA) and mediate the resistance of glioblastoma cells to PDGFRA inhibitor.

[Developmental Cell] The authors showed that reverse electron transfer through respiratory chain complex I was particularly active in brain CSCs.

[Scientific Reports] Using in silico and in vitro techniques, investigators demonstrated heterogeneous expression of CD97, a leukocyte adhesion marker, in human glioblastoma.