graft-versus-host disease

[Bone Marrow Transplantation] Scientists reported on 318 patients with acute leukemia, receiving donor lymphocyte infusion in complete hematologic remission after allogeneic stem cell transplantation.

[Pharmacogenomics Journal] Scientists explored 51 variants within 17 DNA-repair genes for their association with acute graft versus host disease grades two–four in 60 pediatric patients.

[International Journal of Hematology] The authors evaluated the effect of reducing the melphalan dose and retrospectively compared transplant outcomes in 156 patients who received FB2 (n = 103) or FM80 (n = 53) at the center (median age: 63 years; range 27–72 years).

[Nature Immunology] Intestinal epithelial cell (IEC) damage by T cells contributes to graft-versus-host disease, inflammatory bowel disease and immune checkpoint blockade-mediated colitis. The relevance of IEC-intrinsic succinate dehydrogenase A in mediating disease severity was confirmed by complementary chemical and genetic experimental approaches and validated in human clinical samples.

[British Journal of Haematology] Investigators provide a comprehensive review of the challenges associated with autologous CAR, the benefits and potential challenges associated with allogenic-CAR.

[Bone Marrow Transplantation] Investigators reported on all 17 patients with BPDCN who underwent allogeneic hematopoietic cell transplantation (allo-HCT) at their center between 2000 and 2020, and concluded that allo-HCT provided long-lasting remissions in BPDCN patients, particularly when performed in complete remission.