hematopoietic stem cells

[Stem Cell Reviews and Reports] The authors focus on how to progress in vitro generation of platelets from stem cell, especially iPSCs, and describe some of the successful strategies that can be easily used in clinic.

[Nature] Scientists created a single-cell transcriptome map of human hematopoietic tissues from the first trimester to birth and found that the hematopoietic stem cell (HSC) signature RUNX1+HOXA9+MLLT3+MECOM+HLF+SPINK2+ distinguished HSCs from progenitors throughout gestation.

[Cell Death & Disease] Scientists discovered that hematopoietic stem and progenitor cells were mainly targeted by acute lymphoblastic leukemia extracellular vesicles, affecting their quiescence and maintenance in the murine bone marrow environment.

[Human Vaccines & Immunotherapeutics] Scientists investigated the effects of CYNK-001, human placental hematopoietic stem cell derived NK cells that exhibited strong cytolytic activity against a range of malignant cells and expressed high levels of activating receptors, against influenza A virus infections.

[Journal of Immunology Research] Using multiparametric flow cytometry, scientists identified mesenchymal, endothelial, and hematopoietic progenitor cells that express the secreted small protein Isthmin 1.

[Clinical Oncology] Scientists assessed the change in height standard deviation score and the final adult height in children who underwent chemotherapy-only conditioned hematopoietic stem cell transplant and to identify predictors of poor growth.