hematopoietic stem cells

[Cell Metabolism] Investigators compared glucose metabolism in hematopoiesis and leukemia. Thymus T cell progenitors were glucose avid and oxidized more glucose in the tricarboxylic acid cycle through pyruvate dehydrogenase as compared with other hematopoietic cells.

[Blood] The authors showed that sympathetic nerve-derived dopamine directly controlled hematopoietic stem and progenitor cell behavior through D2-subfamily dopamine receptors.

[Blood] Scientists demonstrated that conditional deletion of acidic leucine-rich nuclear phosphoprotein 32B (ANP32B) in hematopoietic cells impaired repopulation capacity and post-injury regeneration of HSCs.

[American Journal of Hematology] Investigators evaluated the most optimal donor for young acute leukemia patients with multiple donors available for allogeneic hematopoietic stem cell transplantation, including HLA-matched sibling donors, HLA-matched unrelated donors, haploidentical parental donors, and haploidentical sibling donors.

[Stem Cell Research & Therapy] The authors proposed a new hematopoietic stem and progenitor cell (HSPC) senescence model in vitro which they forecasted could be used to preliminary screen the drugs of the HSPC aging-related hemopathy and suggested cellular memory mechanism of HSPC aging.

[Advanced Science] Transcriptomic analysis showed that IFN-γ and IFN-α signaling was downregulated in IRF8-deficient HSCs, while their response to proinflammatory cytokines was unchanged ex vivo.