hematopoietic stem cells

[Science China-Life Sciences] The authors describe the “self-renewal, multi-lineage differentiation, apoptosis, rest, and trafficking” or “SMART” model, which has been developed based on data derived from studies of HSCs as the most well-characterized stem cell type.

[Blood] To target CD70 on acute myeloid leukemia cells, researchers generated a panel of CD70-CAR T cells that contained a common single-chain variable fragment for antigen detection, but differed in size and flexibility of the extracellular spacer and in the transmembrane and the costimulatory domains.

[Cell Discovery] The authors used single-cell RNA sequencing to assess bone marrow mononuclear cells from COVID-19 patients with peripheral blood mononuclear cells as control, and showed that the HSCs in these patients were mainly in the G1 phase and prone to apoptosis, with immune activation and anti-viral responses.

[Kite, a Gilead Company] Kite, a Gilead Company and Appia Bio, Inc. announced a collaboration and license agreement to research and develop hematopoietic stem cells-derived cell therapies directed toward hematological malignancies.

[Stem Cells Translational Medicine] Scientists investigated if MSCs derived from the amniotic membrane could support the ex vivo expansion of hematopoietic stem cell and progenitor cells.

[Blood] The authors examined the consequences of conditional inactivation of Lsd1 in adult red blood cells using a new Gata1creERT2 BAC transgene. The analogous phenotype was observed in human hematopoietic stem and progenitor cells, coincident with induction of myeloid transcription factors.