hepatic cells

[Biomaterials Science] Researchers reported a facile and efficient strategy for in vivo tracking the secretion of hepatocyte growth factor in MSCs during idiopathic pulmonary fibrosis therapy.

[Stem Cell Research & Therapy] A type 2 diabetes mellitus (T2DM) model was established through 28-week high-fat diet feeding resulting in T2DM-associated non-alcoholic fatty liver disease, followed by the injection of bone marrow MSCs.

[Nature Communications] Hepatocyte-specific deletion of Mettl3 drove nonalcoholic fatty liver-to-NASH progression by increasing CD36-mediated hepatic free fatty acid uptake and CCL2-induced inflammation, which is due to increased chromatin accessibility in the promoter region of Cd36 and Ccl2.

[Nature Aging] Scientists showed accurate tracking of the aging process in hepatocytes, demonstrated attenuated epigenetic aging in muscle stem cells and tracked age dynamics in embryonic stem cells.

[Scientific Reports] The authors investigated miR1908-5p function by leveraging human primary hepatocytes and HuH-7 hepatoma models and implicated miR1908-5p in metabolic and energy regulation in hepatocyte models via multiple, independent, pathways.

[Biomaterials] Human primary hepatocyte organoids and HepaRG spheroids showed more mature hepatocyte phenotype after adding fibronectin and fibrinogen to the culture system.