Sirt1 Deacetylates and Stabilizes p62 to Promote Hepato-Carcinogenesis

Scientists confirmed that p62 was up-regulated in hepatocellular carcinoma and its higher expression was associated with shorter overall survival in patients.
[Cell Death & Disease]
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Assessment of Long-Term Functional Maintenance of Primary Human Hepatocytes to Predict Drug-Induced Hepatoxicity In Vitro

Scientists developed a conditioned culture system composed of a small-molecule combination that can maintain hepatocyte morphology and functions over the long term.
[Archives of Toxicology]
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Hepatic Fibroblast Growth Factor 21 Is Involved in Mediating Functions of Liraglutide in Mice with Dietary Challenge

As GLP-1 receptor (GLP-1R) is unlikely expressed in hepatocytes, scientists aimed to compare such stimulation in mice and in mouse-hepatocytes; determined the involvement of GLP-1R, and clarified whether FGF21 mediated certain functions of the GLP-1R agonist liraglutide.
[Hepatology]
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3D Cell Sheet Structure Augments Mesenchymal Stem Cell Cytokine Production

MSCs cultivated on temperature-responsive culture dishes to a confluent 2D monolayer were harvested by temperature reduction from 37 to 20°C that induced a surface wettability transition from hydrophobic to hydrophilic.
[Scientific Reports]
Bou-Ghannam, S., Kim, K., Grainger, D. W., & Okano, T. (2021). 3D cell sheet structure augments mesenchymal stem cell cytokine production. Scientific Reports, 11(1), 8170. https://doi.org/10.1038/s41598-021-87571-7 Cite
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Bmal1 Inhibits Phenotypic Transformation of Hepatic Stellate Cells in Liver Fibrosis via IDH1/α-KG-Mediated Glycolysis

Scientists showed that glycolysis was significantly enhanced, while the expression of brain and muscle arnt-like protein-1 (Bmal1) was downregulated in fibrotic liver tissues of mice, primary Hepatic stellate cells (HSCs), and transforming growth factor-β1 (TGF-β1)-induced LX2 cells.
[Acta Pharmaceutica Sinica B]
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Synergistic Effect of the TLR5 Agonist CBLB502 and Its Downstream Effector IL-22 against Liver Injury

Scientists investigated the protective mechanism of CBLB502 in the liver using models of ischemia-reperfusion injury and concanavalin A induced immuno-hepatitis.
[Cell Death & Disease]
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Global Changes to HepG2 Cell Metabolism in Response to Galactose Treatment

Scientists performed transcriptomic and metabolomic analyses on human hepatocellular carcinoma cells adapted to either glucose or galactose as the aldohexose source.
[American Journal of Physiology-Cell Physiology]
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CAR Directs T Cell Adaptation to Bile Acids in the Small Intestine

Scientists identified the nuclear xenobiotic receptor CAR as a regulator of MDR1 expression in T cells that could safeguard against bile acid toxicity and inflammation in the mouse small intestine.
[Nature]
Chen, M. L., Huang, X., Wang, H., Hegner, C., Liu, Y., Shang, J., Eliason, A., Diao, H., Park, H., Frey, B., Wang, G., Mosure, S. A., Solt, L. A., Kojetin, D. J., Rodriguez-Palacios, A., Schady, D. A., Weaver, C. T., Pipkin, M. E., Moore, D. D., & Sundrud, M. S. (2021). CAR directs T cell adaptation to bile acids in the small intestine. Nature, 1–5. https://doi.org/10.1038/s41586-021-03421-6 Cite
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Small Extracellular Vesicles Derived from Interferon-γ Pre-Conditioned Mesenchymal Stromal Cells Effectively Treat Liver Fibrosis

Investigators analyzed the therapeutic potential of small extracellular vesicles (sEVs) derived from interferon-γ (IFN-γ) pre-conditioned MSCs (γ-sEVs).
[NPJ Regenerative Medicine]
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Ahnak Deficiency Attenuates High-Fat Diet-Induced Fatty Liver in Mice through FGF21 Induction

Ahnak knockdown in hepatocytes reportedly prevented excessive lipid accumulation induced by palmitate treatment and was associated with increased secretion of FGF21 and the expression of genes involved in fatty acid oxidation, which are primarily downstream of PPARα.
[Experimental and Molecular Medicine]
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Experimental Gene Therapy for Hemophilia Probably Did Not Cause Patient’s Liver Tumor

UniQure has concluded that a virus used widely in gene therapy was very unlikely to have caused liver cancer in a hemophilia patient in a clinical trial.
[Science]
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