hepatic cells

[Cell Death & Disease] The authors demonstrated the involvement of hepatic stellate cell-derived hydrogen sulfide (H2S) in JNK/JunB mediated expression of TNFSF14 gene, which indicated that H2S played an important role in the regulation of HCC apoptosis.

[Stem Cell Research & Therapy] Researchers established an in vitro long-term culture system that enabled stable proliferation and maintenance of human hepatocytes to ensure a constant supply.

[Scientific Reports] Clinical hepatocyte transplantation (HT) is only performed without general anesthesia, while inhalation anesthetics are usually used in animal experiments. The authors hypothesized that isoflurane may be a possible reason for the discrepancy between the results of animal experiments and the clinical outcomes of HTx.

[Science Advances] The authors showed that hepatocyte Kruppel-like factor 15 (KLF15) controlled plasma corticosteroid transport and inflammatory responses through direct transcriptional activation of Serpina6, which encoded corticosteroid-binding globulin.

[Journal of Hepatology] Scientists identified a proinflammatory hepatocyte subpopulation that developed primarily from periportal hepatocytes and to a lesser extent from pericentral hepatocytes and played key immunoregulatory roles in endotoxemia.

[Nature] Investigators found that the hepatic subcellular organization of the endoplasmic reticulum architecture were highly dynamic, integrated with the metabolic state and critical for adaptive homeostasis and tissue health.