hepatic cells

[Hepatology] Investigators established a hepatocyte aging model from human induced pluripotent stem cells and developed a method for ex vivo characterization of hepatocyte plasticity.

[Molecular Cell] Scientists showed that the amino acid-induced Ubr1 activity was necessary to prevent steatosis in mouse livers and cultured human hepatocytes, providing molecular insight into the anti-nonalcoholic fatty liver disease effects of dietary protein/amino acids.

[iScience] The effects of ALAHM on hepatocyte paracrine HGF as well as proliferation, invasion, and migration of lung adenocarcinoma cells were observed in vitro.

[Nature Communications] Hepatocyte nicotinamide phosphoribosyltransferase conveyed key aspects of the fasting response, which selectively dissociated through hepatocyte SIRT1.

[Nature Communications] Targeting Mat1a activated the liver-brown adipose tissue axis by increasing NRF2-mediated FGF21 secretion, which prevented obesity, insulin resistance and hepatosteatosis.

[Frontiers in Neurology] Investigators found that the proportions of CD19+ IL-10+ cells and CD19+CD24hiCD38hi cell subsets in myasthenia gravis patients were significantly lower than those in healthy controls.