Methionine Adenosyltransferase 1a Antisense Oligonucleotides Activate the Liver-Brown Adipose Tissue Axis Preventing Obesity and Associated Hepatosteatosis

By
Justin.choi
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0
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Targeting Mat1a activated the liver-brown adipose tissue axis by increasing NRF2-mediated FGF21 secretion, which prevented obesity, insulin resistance and hepatosteatosis.
[Nature Communications]

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