Selenoprotein P Inhibits Cell Proliferation and ROX Production in HCC Cells

Researchers observed the expression of selenoprotein P in livers from patients with hepatocellular carcinoma (HCC) and explored its effect on HCC cells.
[PLoS One]
Wang, J., Shen, P., Liao, S., Duan, L., Zhu, D., Chen, J., Chen, L., Sun, X., & Duan, Y. (2020). Selenoprotein P inhibits cell proliferation and ROX production in HCC cells. PLOS ONE, 15(7), e0236491. https://doi.org/10.1371/journal.pone.0236491 Cite
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Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Investigators showed that berberine administration markedly ameliorated intralipid-induced insulin resistance without affecting blood glucose. They used human skeletal muscle cells, hepatocytes, human umbilical vein endothelial cells, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
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The AKT-Independent MET–V-ATPase–Mtor Axis Suppresses Liver Cancer Vaccination

Scientists investigated the regulatory effect and potential mechanism of hepatocyte growth factor receptor (MET, also known as HGFR) on tumor vaccinations for liver cancer in mice.
[Signal Transduction and Targeted Therapy]
Huang, X., Xu, X., Wang, X., Tang, T., Li, E., Zhang, X., Xu, J., Shen, H., Guo, C., Xu, T., Ren, J., Bai, X., & Liang, T. (2020). The AKT-independent MET–V-ATPase–MTOR axis suppresses liver cancer vaccination. Signal Transduction and Targeted Therapy, 5(1), 1–10. https://doi.org/10.1038/s41392-020-0179-x Cite
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HNF4α Regulates Sulfur Amino Acid Metabolism and Confers Sensitivity to Methionine Restriction in Liver Cancer

The authors report that hepatocyte nuclear factor 4α (HNF4α) dictated the sensitivity of liver cancer to methionine restriction. They showed that hepatic sulfur amino acid metabolism was under transcriptional control of HNF4α.
[Nature Communications]
Xu, Q., Li, Y., Gao, X., Kang, K., Williams, J. G., Tong, L., Liu, J., Ji, M., Deterding, L. J., Tong, X., Locasale, J. W., Li, L., Shats, I., & Li, X. (2020). HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer. Nature Communications, 11(1), 3978. https://doi.org/10.1038/s41467-020-17818-w Cite
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Immunological Distinctions between Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma

The objective of this study was to differentiate the roles of specific immune cell subsets in nonalcoholic steatohepatitis and hepatocellular carcinoma pathogenesis.
[Experimental and Molecular Medicine]
Koo, S.-Y., Park, E.-J., & Lee, C.-W. (2020). Immunological distinctions between nonalcoholic steatohepatitis and hepatocellular carcinoma. Experimental & Molecular Medicine, 1–11. https://doi.org/10.1038/s12276-020-0480-3 Cite
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Reduced Mrp2 Surface Availability as PI3Kγ-Mediated Hepatocytic Dysfunction Reflecting a Hallmark of Cholestasis in Sepsis

Keeping the surface availability of the biliary transporter Mrp2 is a cell biological process that may underlie the observation that PI3Kγ loss-of-function protects from hepatic excretory dysfunction during early sepsis
[Scientific Reports]
Beer, A. J., Hertz, D., Seemann, E., Beretta, M., Westermann, M., Bauer, R., Bauer, M., Kessels, M. M., & Qualmann, B. (2020). Reduced Mrp2 surface availability as PI3Kγ-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis. Scientific Reports, 10(1), 13110. https://doi.org/10.1038/s41598-020-69901-3 Cite
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HGF and IL-10 Expressing ALB::GFP Reporter Cells Generated From iPSCs Show Robust Anti-Fibrotic Property in Acute Fibrotic Liver Model

Induced hepatocyte-like (iHep) cells were generated from induced pluripotent stem cells integrated with the albumin reporter gene. The therapeutic properties of these iHep cells were investigated after transplantation in fibrotic liver tissues of a mouse model.
[Stem Cell Research & Therapy]
Choi, J. S., Jeong, I. S., Park, Y.-J., & Kim, S.-W. (2020). HGF and IL-10 expressing ALB::GFP reporter cells generated from iPSCs show robust anti-fibrotic property in acute fibrotic liver model. Stem Cell Research & Therapy, 11(1), 332. https://doi.org/10.1186/s13287-020-01745-0 Cite
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Intestinal TLR9 Deficiency Exacerbates Hepatic IR Injury via Altered Intestinal Inflammation and Short‐Chain Fatty Acid Synthesis

Mice lacking intestinal TLR9 had profoundly increased liver injury after hepatic ischemia reperfusion(IR) compared to WT mice with exacerbated hepatocyte necrosis, apoptosis, neutrophil infiltration, and inflammatory cytokine generation. They also observed increased small intestinal inflammation and apoptosis after hepatic IR in intestinal TLR9 deficient mice. Fecal short‐chain fatty acids butyrate and propionate levels were lower in intestinal TLR9 deficient mice.
[FASEB Journal]
Han, S. J., Kim, M., Novitsky, E., D’Agati, V., & Lee, H. T. (n.d.). Intestinal TLR9 deficiency exacerbates hepatic IR injury via altered intestinal inflammation and short-chain fatty acid synthesis. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.202000314R Cite
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Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
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Immunological Distinctions between Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma

the liver is a central player in immunoregulation. Altered immune responses are tightly associated with the development of non-alcoholic steatohepatitis and hepatocellular carcinoma.
[Experimental and Molecular Medicine]
Koo, S.-Y., Park, E.-J., & Lee, C.-W. (2020). Immunological distinctions between nonalcoholic steatohepatitis and hepatocellular carcinoma. Experimental & Molecular Medicine, 1–11. https://doi.org/10.1038/s12276-020-0480-3 Cite
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Human Umbilical Cord-Derived Mesenchymal Stem Cells Prevent the Progression of Early Diabetic Nephropathy through Inhibiting Inflammation and Fibrosis

Scientists identified the basic biological properties and examined the multilineage differentiation potential of umbilical cord-MSCs.
[Stem Cell Research & Therapy]
Xiang, E., Han, B., Zhang, Q., Rao, W., Wang, Z., Chang, C., Zhang, Y., Tu, C., Li, C., & Wu, D. (2020). Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Research & Therapy, 11(1), 336. https://doi.org/10.1186/s13287-020-01852-y Cite
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Pleiotropic Roles of Platelets and Neutrophils in Cell Death and Recovery during Acetaminophen Hepatotoxicity

The role of platelets in liver biology and pathophysiology has attracted increased attention during the last decade.
[Hepatology]
Jaeschke, H., & Ramachandran, A. (n.d.). Pleiotropic Roles of Platelets and Neutrophils in Cell Death and Recovery during Acetaminophen Hepatotoxicity. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31490 Cite
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