Scientists investigated the protective mechanism of CBLB502 in the liver using models of ischemia-reperfusion injury and concanavalin A induced immuno-hepatitis.
[Cell Death & Disease]
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Scientists performed transcriptomic and metabolomic analyses on human hepatocellular carcinoma cells adapted to either glucose or galactose as the aldohexose source.
[American Journal of Physiology-Cell Physiology]
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Scientists identified the nuclear xenobiotic receptor CAR as a regulator of MDR1 expression in T cells that could safeguard against bile acid toxicity and inflammation in the mouse small intestine.
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Chen, M. L., Huang, X., Wang, H., Hegner, C., Liu, Y., Shang, J., Eliason, A., Diao, H., Park, H., Frey, B., Wang, G., Mosure, S. A., Solt, L. A., Kojetin, D. J., Rodriguez-Palacios, A., Schady, D. A., Weaver, C. T., Pipkin, M. E., Moore, D. D., & Sundrud, M. S. (2021). CAR directs T cell adaptation to bile acids in the small intestine. Nature, 1–5. https://doi.org/10.1038/s41586-021-03421-6 Cite
Investigators analyzed the therapeutic potential of small extracellular vesicles (sEVs) derived from interferon-γ (IFN-γ) pre-conditioned MSCs (γ-sEVs).
[NPJ Regenerative Medicine]
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Ahnak knockdown in hepatocytes reportedly prevented excessive lipid accumulation induced by palmitate treatment and was associated with increased secretion of FGF21 and the expression of genes involved in fatty acid oxidation, which are primarily downstream of PPARα.
[Experimental and Molecular Medicine]
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UniQure has concluded that a virus used widely in gene therapy was very unlikely to have caused liver cancer in a hemophilia patient in a clinical trial.
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Scientists investigated the potential role of IL37 in hepatic ischemia reperfusion injury and its underlying molecular mechanism.
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Scientists found that patients with early natural killer cell activation after PEG–IFN-α injection experienced greater liver inflammation, lysis of HBV-infected hepatocytes, and hepatitis B surface antigen decline than those without.
[Science Translational Medicine]
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Nishio, A., Bolte, F. J., Takeda, K., Park, N., Yu, Z.-X., Park, H., Valdez, K., Ghany, M. G., & Rehermann, B. (2021). Clearance of pegylated interferon by Kupffer cells limits NK cell activation and therapy response of patients with HBV infection. Science Translational Medicine, 13(587). https://doi.org/10.1126/scitranslmed.aba6322 Cite
Investigators focused on the culture of cells harvested from hepatocellular carcinoma (HCC) patient-derived xenografts (PDXs) as organoids using a cellulosic macroporous sponge scaffold
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Researchers revealed a metabolic inter-tissue cross-talk that links skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
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Scientists demonstrated that gene related to anergy in lymphocytes regulated the lipid accumulation in hepatic steatosis via interaction with sirtuin 1.
[Cell Death & Disease]
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