Untargeted nuclear magnetic resonance metabolomics was applied in 84 umbilical cord blood and maternal blood samples obtained from 48 intrauterine growth restriction and 36 appropriate for gestational age deliveries.
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Moros, G., Boutsikou, T., Fotakis, C., Iliodromiti, Z., Sokou, R., Katsila, T., Xanthos, T., Iacovidou, N., & Zoumpoulakis, P. (2021). Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics. Scientific Reports, 11(1), 7824. https://doi.org/10.1038/s41598-021-87323-7 Cite
Investigators showed that inhibiting serpinB13, a cathepsin L protease inhibitor expressed in the pancreatic epithelium, caused in vitro and in vivo cleavage of the extracellular domain of Notch1.
[Science Translational Medicine]
Researchers explored the underlying mechanisms of how pancreatic ductal adenocarcinoma-derived exosomes modulate the liver microenvironment and promote metastasis.
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The authors discuss the local and systemic roles of adipose tissue derived secreted factors and increased systemic inflammation during obesity and highlight their detrimental impact on cardiovascular health.
Researchers used a cell-tagging dye, CFDA-SE, to permanently label pancreatic duct cells through an intraductal infusion technique.
[Experimental and Molecular Medicine]
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The authors discuss the development of the most widely available insulin preparations and provide evidence-based insight into their use in clinical practice.
Scientists discuss the discoveries that have led to the current understanding of how insulin promotes glucose uptake in muscle.
Investigators discuss current challenges surrounding the generation, delivery, and engraftment of stem cell-derived islet-like cells, along with strategies to induce durable tolerance to grafted cells, with an eye toward a functional cellular-based therapy enabling insulin independence for patients with diabetes.
Researchers suggested that accumulation of endogenous mtdsRNA following degradosome knockdown depended on the proliferative capacity of the cells and was not a mediator of the type I interferon response in human pancreatic beta cells.
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Coomans de Brachène, A., Castela, A., Musuaya, A. E., Marselli, L., Marchetti, P., & Eizirik, D. L. (2021). Endogenous mitochondrial double‐stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells. Autoimmunity Highlights, 12(1), 6. https://doi.org/10.1186/s13317-021-00148-2 Cite
Scientists showed that hydrophobic components of bitter melon fruit extract increased ATP production and augmented insulin secretion from β-cells, consequently decreasing blood glucose levels.
[British Journal of Nutrition]
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Bitter melon fruit extract enhances intracellular ATP production and insulin secretion from rat pancreatic β-cells | British Journal of Nutrition | Cambridge Core. (n.d.). Retrieved March 30, 2021, from https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/bitter-melon-fruit-extract-enhances-intracellular-atp-production-and-insulin-secretion-from-rat-pancreatic-cells/B388E6AC085C0B1DB936801BDC00EF61 Cite
The effects of fetuin-A were assessed during in vitro maturation of porcine neonatal islet cell clusters and in adult human islets. Expression alterations were examined via microarray, RNA sequencing and reverse transcription quantitative real-time PCR, proteins were analyzed by western blotting and immunostaining, and insulin secretion was quantified in static incubations.
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The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells | SpringerLink. (n.d.). Retrieved March 30, 2021, from https://link.springer.com/article/10.1007%2Fs00125-021-05435-1 Cite