A Medium Composition Containing Normal Resting Glucose That Supports Differentiation of Primary Human Airway Cells

Investigators expanded and differentiated human basal cells isolated from the nasal and conducting airway to a mature mucociliary epithelial cell layer at air–liquid interface using a medium formulation containing normal resting glucose levels.
[Scientific Reports]
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Nampt Activator P7C3 Ameliorates Diabetes and Improves Skeletal Muscle Function Modulating Cell Metabolism and Lipid Mediators

Researchers assessed the functional, morphometric, biochemical, and molecular effects of P7C3 treatment in skeletal muscle of type 2 diabetic (db/db) mice.
[Journal of Cachexia Sarcopenia and Muscle]
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SENP2 Regulates Mitochondrial Function and Insulin Secretion in Pancreatic β Cells

Using a cell culture system of NIT-1, an islet β cell line, scientists found that increased small ubiquitin-like modifier (SUMO) 2/3 conjugation to DRP1 due to SUMO-specific protease 2 (SENP2) deficiency suppressed the phosphorylation of DRP1, which possibly induced mitochondrial dysfunction.
[Experimental and Molecular Medicine]
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Antioxidation of a Proteoglycan from Ganoderma lucidum Protects Pancreatic β-Cells against Oxidative Stress-Induced Apoptosis In Vitro and In Vivo

Researchers investigated systematically the roles of a proteoglycan from Ganoderma lucidum in protection and repair of pancreatic β-cells against oxidative stress-induced injury and apoptosis on molecular, cellular and animal basis.
[International Journal of Biological Macromolecules]
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Urocortin3: Local Inducer of Somatostatin Release and Bellwether of Beta Cell Maturity

Scientists review the mechanistic underpinnings of urocortin 3 signaling, its net effect on islet cell hormone output, as well as its value as a marker for beta cell maturation and functional status.
[Peptides]
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Enrichment of the Exocytosis Protein STX4 in Skeletal Muscle Remediates Peripheral Insulin Resistance and Alters Mitochondrial Dynamics via Drp1

Researchers showed that transgenic skeletal muscle-specific STX4 enrichment in mice reverses established insulin resistance and improves mitochondrial function in the context of diabetogenic stress.
[Nature Communications]
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SENP2 Regulates Mitochondrial Function and Insulin Secretion in Pancreatic β Cells

Researchers investigated the function of SENP2 in pancreatic β cells by generating a β cell-specific knockout mouse model.
[Experimental and Molecular Medicine]
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Sodium Butyrate Potentiates Insulin Secretion from Rat Islets at the Expense of Compromised Expression of β Cell Identity Genes

Overlapping analysis of H3K27Ac ChIP-seq and RNA-seq showed that the inhibitory effect of SB on the expression of multiple β cell identity genes was independent of H3K27Ac.
[Cell Death & Disease]
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FOXP3 Activated-LINC01232 Accelerates the Stemness of Non-Small Cell Lung Carcinoma by Activating TGF-β Signaling Pathway and Recruiting IGF2BP2 to Stabilize TGFBR1

Flow cytometry and sphere formation assays indicated that LINC01232 significantly promoted non-small cell lung carcinoma cell stemness.
[Experimental Cell Research]
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The Idd2 Locus Confers Prominent Resistance to Autoimmune Diabetes

Researchers generated a NOD congenic mouse bearing B10 resistance alleles on chromosome 9 in a locus coinciding with part of the insulin-dependent diabetes (Idd) locus and found that NOD.
[Journal of Immunology]
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Involvement of m6A Regulatory Factor IGF2BP1 in Malignant Transformation of Human Bronchial Epithelial Beas-2B Cells Induced by Tobacco Carcinogen NNK

Scientists performed colony formation assays, soft-agar assays, and tumor growth in nude mice to show that 100 mg/L Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) facilitated the malignant transformation of human bronchial epithelial Beas-2B cells.
[Toxicology and Applied Pharmacology]
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