Sulforaphane Ameliorates Non-Alcoholic Fatty Liver Disease in Mice by Promoting FGF21/FGFR1 Signaling Pathway

Scientists investigated whether fibroblast growth factor 21 (FGF21) was involved in the therapeutic effect of sulforaphane against non-alcoholic fatty liver disease.
[Acta Pharmacologica Sinica]
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Convergent Somatic Mutations in Metabolism Genes in Chronic Liver Disease

Scientists analyzed somatic mutations from 1,590 genomes across 34 liver samples, including healthy controls, alcohol-related liver disease and non-alcoholic fatty liver disease. Seven of the 29 patients with liver disease had mutations in FOXO1, the major transcription factor in insulin signaling.
[Nature]
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m6A Reader IGF2BP2-Stabilized CASC9 Accelerates Glioblastoma Aerobic Glycolysis by Enhancing HK2 mRNA Stability

MeRIP-Seq revealed the m6A profile in the glioblastoma multiforme (GBM). Moreover, the m6A-related long non-coding RNA CASC9 expression was significantly elevated in the GBM tissue and its ectopic high expression was associated with poor survival, acting as an independent prognostic factor for GBM patients.
[Cell Death Discovery]
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Endurance Exercise Training-Responsive miR-19b-3p Improves Skeletal Muscle Glucose Metabolism

Scientists showed that overexpression of miR-19b-3p in human skeletal muscle cells increased insulin signaling, glucose uptake, and maximal oxygen consumption, recapitulating the adaptive response to aerobic exercise training.
[Nature Communications]
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SNAIL2 Contributes to Tumorigenicity and Chemotherapy Resistance in Pancreatic Cancer by Regulating IGFBP2

Scientists showed that the suppression of SNAIL2 expression using RNA interference decreased tumorigenicity in vitro and in vivo in two pancreatic cancer cell lines, KLM1 and KMP5.
[Cancer Science]
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Charting the Next Century of Insulin Replacement with Cell and Gene Therapies

Investigators celebrate the 100th anniversary of the discovery of insulin and consolidate the key milestones and advances in the development of recombinant human insulin.
[Med]
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vTv Therapeutics Announces Positive Results from Mechanistic Study Indicating No Increased Risk of Ketoacidosis with TTP399 during Acute Insulin Withdrawal in Patients with Type 1 Diabetes

vTv Therapeutics, Inc. a clinical-stage biopharmaceutical company focused on the development of orally administered treatments for type 1 diabetes and psoriasis, announced positive results of a mechanistic study of TTP399 in patients with type 1 diabetes.
[vTv Therapeutics, Inc.]
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Conditions for Maintenance of Hepatocyte Differentiation and Function in 3D Cultures

Spheroid cultures of primary human hepatocytes are used in studies of hepatic drug metabolism and toxicity. The authors performed an in-depth analysis of the influence of various culture conditions to find the optimal conditions for the maintenance of an in vivo like phenotype.
[iScience]
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A20 Controls Expression of Beta-Cell Regulatory Genes and Transcription Factors

Scientists investigated the mechanisms underlying the protective role of A20 in the pancreatic beta-cell. Investigators demonstrated a role for A20 in controling beta-cell integrity and survival, which likely resulted from the regulation of inflammatory signaling
[Journal of Molecular Endocrinology]
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Detecting Insulitis in Type 1 Diabetes with Ultrasound Phase-Change Contrast Agents

Researchers presented ultrasound imaging of nanodroplet (ND) contrast-agent accumulation within the islet. ND accumulation is dependent on immune infiltration; therefore, it tracked presymptomatic type I diabetes development and progression to diabetes
[Proceedings of the National Academy of Sciences of the United States of America]
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1α, 25-(OH)2 Vitamin D3 Prevents Insulin Resistance and Regulates Coordinated Exocytosis and Insulin Secretion

Researchers investigated the short-term effect of 1α,25(OH)2 vitamin D3 and cholecalciferol on the glycemia and insulin sensitivity of control and dexamethasone-induced insulin-resistance in rats.
[Journal of Nutritional Biochemistry]
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