Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Investigators showed that berberine administration markedly ameliorated intralipid-induced insulin resistance without affecting blood glucose. They used human skeletal muscle cells, hepatocytes, human umbilical vein endothelial cells, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
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Neohesperidin Enhances PGC-1α-Mediated Mitochondrial Biogenesis and Alleviates Hepatic Steatosis in High Fat Diet Fed Mice

Neohesperidin (NHP) elevated hepatic mitochondrial biogenesis and fatty acid oxidation by increasing PGC-1α expression. The activation of AMP-activated protein kinase was involved in NHP induced PGC-1α expression.
[FASEB Journal]
Wang, S., Sheng, H., Bai, Y., Weng, Y., Fan, X., Lou, L., & Zhang, F. (2020). Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed mice. Nutrition & Diabetes, 10(1), 1–11. https://doi.org/10.1038/s41387-020-00130-3 Cite
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Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
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Lentiviral Gene Therapy Vectors Encoding VIP Suppressed Diabetes-Related Inflammation and Augmented Pancreatic Beta-Cell Proliferation

The authors suggested the observed therapeutic effect of lentiviral vector carrying vasoactive intestinal peptide(VIP) gene was due to the repression of diabetes-induced inflammation, its insulinotropic properties, and VIP-induced beta-cell proliferation.
[Gene Therapy]
Erendor, F., Sahin, E. O., Sanlioglu, A. D., Balci, M. K., Griffith, T. S., & Sanlioglu, S. (2020). Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Gene Therapy, 1–12. https://doi.org/10.1038/s41434-020-0183-3 Cite
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IL-17F Induces Inflammation, Dysfunction and Cell Death in Mouse Islets

IL-17F possessed similar pathogenic activities to IL-17A in mouse β-cell lines and islets and was likely to be a type 17 associated pathogenic factor in type 1 diabetes.
[Scientific Reports]
Catterall, T., Fynch, S., Kay, T. W. H., Thomas, H. E., & Sutherland, A. P. R. (2020). IL-17F induces inflammation, dysfunction and cell death in mouse islets. Scientific Reports, 10(1), 13077. https://doi.org/10.1038/s41598-020-69805-2 Cite
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ISL2 Modulates Angiogenesis through Transcriptional Regulation of ANGPT2 to Promote Cell Proliferation and Malignant Transformation in Oligodendroglioma

Investigators established novel oligodendroglioma patient tumor-derived orthotopic xenograft mouse models and cell lines to verify the role of ISL2 in regulating angiogenesis to promote oligodendroglioma growth and malignant transformation.
[Oncogene]
Qi, L., Wang, Z.-Y., Shao, X.-R., Li, M., Chen, S.-N., Liu, X.-Q., Yan, S., Zhang, B., Zhang, X.-D., Li, X., Zhao, W., Pan, J.-A., Zhao, B., & Zhang, X.-D. (2020). ISL2 modulates angiogenesis through transcriptional regulation of ANGPT2 to promote cell proliferation and malignant transformation in oligodendroglioma. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01411-y Cite
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Lentiviral Gene Therapy Vectors Encoding VIP Suppressed Diabetes-Related Inflammation and Augmented Pancreatic Beta-Cell Proliferation

The authors suggest the observed therapeutic effect of lentiviral vector carrying VIP gene was due to the repression of diabetes-induced inflammation, its insulinotropic properties, and VIP-induced beta-cell proliferation.
[Gene Therapy]
Erendor, F., Sahin, E. O., Sanlioglu, A. D., Balci, M. K., Griffith, T. S., & Sanlioglu, S. (2020). Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Gene Therapy, 1–12. https://doi.org/10.1038/s41434-020-0183-3 Cite
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DGAT1 Inhibitors Protect Pancreatic β-Cells from Palmitic Acid-Induced Apoptosis

Researchers evaluated the potential beneficial effects of DGAT1 inhibitors on pancreatic β-cells, and further verified their antidiabetic effects in db/db mice.
[Acta Pharmacologica Sinica]
Huang, J., Guo, B., Wang, G., Zeng, L., Hu, Y., Wang, T., & Wang, H. (2020). DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis. Acta Pharmacologica Sinica, 1–8. https://doi.org/10.1038/s41401-020-0482-7 Cite
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Lentiviral Gene Therapy Vectors Encoding VIP Suppressed Diabetes-Related Inflammation and Augmented Pancreatic Beta-Cell Proliferation

The therapeutic efficacy of LentiVIP was tested in a multiple low-dose STZ-induced animal model of type 1 diabetes. LentiVIP delivery into diabetic animals reduced hyperglycemia, improved glucose tolerance, and prevented weight loss.
[Gene Therapy]
Erendor, F., Sahin, E. O., Sanlioglu, A. D., Balci, M. K., Griffith, T. S., & Sanlioglu, S. (2020). Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Gene Therapy, 1–12. https://doi.org/10.1038/s41434-020-0183-3 Cite
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LINC00324 Affects Non-Small Cell Lung Cancer Cell Proliferation and Invasion through Regulation of the miR-139-5p/IGF1R Axis

Scientists demonstrated whether LINC00324 participates in non-small cell lung cancer pathogenesis through other molecular mechanism.
[Molecular and Cellular Biochemistry]
Zhang, M., Lin, B., Liu, Y., Huang, T., Chen, M., Lian, D., Deng, S., & Zhuang, C. (2020). LINC00324 affects non-small cell lung cancer cell proliferation and invasion through regulation of the miR-139-5p/IGF1R axis. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-020-03819-2 Cite
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Identification of an Anti-Diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action

In rat cells and in mouse and human islets, SRI-37330 inhibited expression and signaling of thioredoxin-interacting protein, previously found to be elevated in diabetes and to have detrimental effects on islet function.
[Cell Metabolism]
Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action: Cell Metabolism. (n.d.). Retrieved July 28, 2020, from https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30360-0 Cite
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Insulin2Q104del (Kuma) Mutant Mice Develop Diabetes with Dominant Inheritance

Scientists generated a novel Kuma mutant mice with p.Q104del in the Insulin2 gene in a BRJ background that exhibited a severe immune deficiency.
[Scientific Reports]
Sakano, D., Inoue, A., Enomoto, T., Imasaka, M., Okada, S., Yokota, M., Koike, M., Araki, K., & Kume, S. (2020). Insulin2 Q104del (Kuma) mutant mice develop diabetes with dominant inheritance. Scientific Reports, 10(1), 12187. https://doi.org/10.1038/s41598-020-68987-z Cite
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