insulin

[Artificial Organs] In vitro studies showed, wharton’s jelly-derived-MSCs that differentiated in the 3D culture have strong properties of insulin-producing cells such as islet-like cells.

[Scientific Reports] Using a genetically encoded sensor for NADPH/NADP+ redox state, researchers showed overexpression of FGFR5 enhanced glucose-stimulated NADPH metabolism in beta-cell lines as well as mouse and human beta-cells

[Cell Reports Medicine] Scientists studied the efficacy of a glucagon-like peptide-1 (GLP-1) and estrogen dual agonist (GLP1-E2) in pancreatic islet protection. GLP1-E2 provided superior protection from insulin-deficient diabetes induced by multiple low-dose streptozotocin and by the Akita mutation in mice than a GLP-1 monoagonist.

[Journal of Translational Medicine] Investigators highlight the role of mitochondria in metabolism secretion coupling in the β-cells and summarize the evidence accumulated for the implication of mitochondria in β-cell dysfunction in diabetes mellitus.

[Endocrinology] The authors addressed the species specificity of growth hormone (GH)-GH receptor activity by investigating GH actions in prostate cancer cell lines derived from a mouse Pten deletion model.

[Nature Communications] Researchers showed the citrullination of pancreatic glucokinase as a result of inflammation, triggering autoimmunity and affecting glucokinase biological functions.