Scientists investigated the protective mechanism of CBLB502 in the liver using models of ischemia-reperfusion injury and concanavalin A induced immuno-hepatitis.
[Cell Death & Disease]
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Scientists performed transcriptomic and metabolomic analyses on human hepatocellular carcinoma cells adapted to either glucose or galactose as the aldohexose source.
[American Journal of Physiology-Cell Physiology]
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Scientists identified the nuclear xenobiotic receptor CAR as a regulator of MDR1 expression in T cells that could safeguard against bile acid toxicity and inflammation in the mouse small intestine.
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Chen, M. L., Huang, X., Wang, H., Hegner, C., Liu, Y., Shang, J., Eliason, A., Diao, H., Park, H., Frey, B., Wang, G., Mosure, S. A., Solt, L. A., Kojetin, D. J., Rodriguez-Palacios, A., Schady, D. A., Weaver, C. T., Pipkin, M. E., Moore, D. D., & Sundrud, M. S. (2021). CAR directs T cell adaptation to bile acids in the small intestine. Nature, 1–5. https://doi.org/10.1038/s41586-021-03421-6 Cite
Ahnak knockdown in hepatocytes reportedly prevented excessive lipid accumulation induced by palmitate treatment and was associated with increased secretion of FGF21 and the expression of genes involved in fatty acid oxidation, which are primarily downstream of PPARα.
[Experimental and Molecular Medicine]
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Scientists investigated the potential role of IL37 in hepatic ischemia reperfusion injury and its underlying molecular mechanism.
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Scientists found that patients with early natural killer cell activation after PEG–IFN-α injection experienced greater liver inflammation, lysis of HBV-infected hepatocytes, and hepatitis B surface antigen decline than those without.
[Science Translational Medicine]
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Nishio, A., Bolte, F. J., Takeda, K., Park, N., Yu, Z.-X., Park, H., Valdez, K., Ghany, M. G., & Rehermann, B. (2021). Clearance of pegylated interferon by Kupffer cells limits NK cell activation and therapy response of patients with HBV infection. Science Translational Medicine, 13(587). https://doi.org/10.1126/scitranslmed.aba6322 Cite
Investigators focused on the culture of cells harvested from hepatocellular carcinoma (HCC) patient-derived xenografts (PDXs) as organoids using a cellulosic macroporous sponge scaffold
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Researchers revealed a metabolic inter-tissue cross-talk that links skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
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Tumor necrosis factor‐α‐induced protein 8‐like 2 suppressed nonalcoholic fatty liver disease (NAFLD) advancement by blocking transforming growth factor‐beta‐activated kinase 1‐c‐Jun NH2‐terminal kinase/p38 pathway and was a promising target molecule for NAFLD therapy.
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Researchers report the use of a nanofibrous hydrogel as a 3D scaffold for the culture and maintenance of functional primary human hepatocytes.
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Researchers showed that Tumor necrosis factor alpha (TNF‐α)-induced protein 8‐like 1 (TIPE1) protects against hepatic steatosis, inflammation, and fibrosis through directly binding apoptosis signal‐regulating kinase 1 (ASK1) and restraining its TNF receptor-associated factor 6‐catalyzed polyubiquitination during the development of nonalcoholic steatohepatitis.
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