IFN-I specifically rewired tryptophan metabolism and induced hepatic tryptophan oxidation to kynurenine via Tdo2, correlating with altered concentrations of serum metabolites upon viral infection.
6445212 66VVAHAQ items 1 apa default asc 1
Lercher, A., Popa, A. M., Viczenczova, C., Kosack, L., Klavins, K., Agerer, B., Opitz, C. A., Lanz, T. V., Platten, M., & Bergthaler, A. (2020). Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis. PLOS Pathogens, 16(10), e1008973. https://doi.org/10.1371/journal.ppat.1008973 Cite
The authors investigated the early transcriptional events of cellular reprogramming triggered by the co‐expression of Oct4, Sox2, Klf4, and c‐Myc in mouse embryonic fibroblasts and mouse hepatocytes.
6445212 BWLECBFN items 1 apa default asc 1
Papathanasiou, M., Tsiftsoglou, S. A., Polyzos, A. P., Papadopoulou, D., Valakos, D., Klagkou, E., Karagianni, P., Pliatska, M., Talianidis, I., Agelopoulos, M., & Thanos, D. (2020). Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes. The EMBO Journal, n/a(n/a), e102236. https://doi.org/10.15252/embj.2019102236 Cite
Investigators analyzed the levels of mRNA transcripts in serum‐starved primary WT and KO mouse hepatocytes using RNA sequencing data, and found that cyclic AMP response element‐binding protein target genes were downregulated.
6445212 KRMKZ3LJ items 1 apa default asc 1
The authors collected the evidence of HGF/c‐Met as a tumor progression and prognostic marker, discussed the anti‐c‐Met therapy in vitro, summarized the outcome of c‐Met inhibitors in clinical trials, and identified potential impetus for future anti‐c‐Met treatments.
[Medicinal Research Reviews]
6445212 AENBEUA7/ items 1 apa default asc 1
Scientists describe a rat liver organoid culture system under in vivo-like steady-state flow conditions; this system was capable of controlling the expansion and differentiation of rat liver organoids over 10 to 15 days.
6445218 7ZDL5KPD items 1 apa default asc 1
Researchers established a human liver organoid (HLO) based screening model for analyzing DILI pathology at organoid resolution. HLO, generated from ten-different pluripotent stem cell lines, contained polarized immature hepatocytes with bile canaliculi-like architecture, establishing the unidirectional bile acid transport pathway.
6445218 AZUQHTJG items 1 apa default asc 1
Shinozawa, T., Kimura, M., Cai, Y., Saiki, N., Yoneyama, Y., Ouchi, R., Koike, H., Maezawa, M., Zhang, R.-R., Dunn, A., Ferguson, A., Togo, S., Lewis, K., Thompson, W., Asai, A., & Takebe, T. (2020). High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.10.002 Cite
Because N-acetyltransferase (NAT) is expressed in hepatocytes, whereas CD38 is expressed in Kupffer cells and hepatic stellate cells, researchers explored cell type-specific roles of CD38 in the formation of a primary INH metabolite mediated isoniazid (INH)-β-nicotinamide adenine dinucleotide (NAD) as well as INH-NAD.
[Drug Metabolism and Disposition]
Investigators found hepatic lipocalin 2 (LCN2) expression and serum LCN2 level markedly increased and correlated with disease severity and portal hypertension in patients with alcoholic hepatitis.
6445212 8998GYPK items 1 apa default asc 1
Investigators provide succinct insights into the molecular mechanisms responsible for lipotoxicity in non-alcoholic fatty liver disease (NAFLD), including ER and oxidative stress, autophagy, lipoapotosis and inflammation. They highlight the role of CD36/FAT fatty acid translocase in NAFLD pathogenesis.
[Cell Death & Disease]
The authors highlight how insights into hepatocyte regeneration and biology in vivo can inform in vitro studies to propagate primary hepatocytes with signals in liver regeneration and to generate hepatocytes de novo from pluripotent stem cells.
[Cellular and Molecular Gastroenterology and Hepatology]
6445212 ZLTIK677 items 1 apa default asc 1
Scientists summarize the results of preclinical and clinical studies dealing with the introduction of epithelial and mesenchymal stem cells of the afterbirth origin to the liver failure therapy.
[Stem Cell Reviews and Reports]
6445212 DLN69FCF items 1 apa default asc 1