Synergistic Effect of the TLR5 Agonist CBLB502 and Its Downstream Effector IL-22 against Liver Injury

Scientists investigated the protective mechanism of CBLB502 in the liver using models of ischemia-reperfusion injury and concanavalin A induced immuno-hepatitis.
[Cell Death & Disease]
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Global Changes to HepG2 Cell Metabolism in Response to Galactose Treatment

Scientists performed transcriptomic and metabolomic analyses on human hepatocellular carcinoma cells adapted to either glucose or galactose as the aldohexose source.
[American Journal of Physiology-Cell Physiology]
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CAR Directs T Cell Adaptation to Bile Acids in the Small Intestine

Scientists identified the nuclear xenobiotic receptor CAR as a regulator of MDR1 expression in T cells that could safeguard against bile acid toxicity and inflammation in the mouse small intestine.
[Nature]
Chen, M. L., Huang, X., Wang, H., Hegner, C., Liu, Y., Shang, J., Eliason, A., Diao, H., Park, H., Frey, B., Wang, G., Mosure, S. A., Solt, L. A., Kojetin, D. J., Rodriguez-Palacios, A., Schady, D. A., Weaver, C. T., Pipkin, M. E., Moore, D. D., & Sundrud, M. S. (2021). CAR directs T cell adaptation to bile acids in the small intestine. Nature, 1–5. https://doi.org/10.1038/s41586-021-03421-6 Cite
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Ahnak Deficiency Attenuates High-Fat Diet-Induced Fatty Liver in Mice through FGF21 Induction

Ahnak knockdown in hepatocytes reportedly prevented excessive lipid accumulation induced by palmitate treatment and was associated with increased secretion of FGF21 and the expression of genes involved in fatty acid oxidation, which are primarily downstream of PPARα.
[Experimental and Molecular Medicine]
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IL37 Overexpression Inhibits Autophagy and Apoptosis Induced by Hepatic Ischemia Reperfusion Injury via Modulating AMPK/mTOR/ULLK1 Signaling Pathways

Scientists investigated the potential role of IL37 in hepatic ischemia reperfusion injury and its underlying molecular mechanism.
[Life Sciences]
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Clearance of Pegylated Interferon by Kupffer Cells Limits NK Cell Activation and Therapy Response of Patients with HBV Infection

Scientists found that patients with early natural killer cell activation after PEG–IFN-α injection experienced greater liver inflammation, lysis of HBV-infected hepatocytes, and hepatitis B surface antigen decline than those without.
[Science Translational Medicine]
Nishio, A., Bolte, F. J., Takeda, K., Park, N., Yu, Z.-X., Park, H., Valdez, K., Ghany, M. G., & Rehermann, B. (2021). Clearance of pegylated interferon by Kupffer cells limits NK cell activation and therapy response of patients with HBV infection. Science Translational Medicine, 13(587). https://doi.org/10.1126/scitranslmed.aba6322 Cite
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Three-Dimensional Macroporous Sponge for the Culture of Hepatocellular Carcinoma Patient-Derived Xenograft Organoids

Investigators focused on the culture of cells harvested from hepatocellular carcinoma (HCC) patient-derived xenografts (PDXs) as organoids using a cellulosic macroporous sponge scaffold
[SLAS TECHNOLOGY]
Toh, T. B., Liu, Z., Yu, H., & Fong, E. L. S. (2021). Three-Dimensional Macroporous Sponge for the Culture of Hepatocellular Carcinoma Patient-Derived Xenograft Organoids. SLAS TECHNOLOGY: Translating Life Sciences Innovation, 24726303211000684. https://doi.org/10.1177/24726303211000685 Cite
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Liver Alanine Catabolism Promotes Skeletal Muscle Atrophy and Hyperglycaemia in Type 2 Diabetes

Researchers revealed a metabolic inter-tissue cross-talk that links skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
[Nature Metabolism]
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Tumor Necrosis Factor‐α‐Induced Protein 8‐like 2 Alleviates Nonalcoholic Fatty Liver Disease via Suppressing TAK1 Activation

Tumor necrosis factor‐α‐induced protein 8‐like 2 suppressed nonalcoholic fatty liver disease (NAFLD) advancement by blocking transforming growth factor‐beta‐activated kinase 1‐c‐Jun NH2‐terminal kinase/p38 pathway and was a promising target molecule for NAFLD therapy.
[Hepatology]
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Peptide-Based Scaffolds for the Culture and Maintenance of Primary Human Hepatocytes

Researchers report the use of a nanofibrous hydrogel as a 3D scaffold for the culture and maintenance of functional primary human hepatocytes.
[Scientific Reports]
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TIPE1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of ASK1

Researchers showed that Tumor necrosis factor alpha (TNF‐α)-induced protein 8‐like 1 (TIPE1) protects against hepatic steatosis, inflammation, and fibrosis through directly binding apoptosis signal‐regulating kinase 1 (ASK1) and restraining its TNF receptor-associated factor 6‐catalyzed polyubiquitination during the development of nonalcoholic steatohepatitis.
[Hepatology]
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