On-Going Consequences of In Utero Exposure of Pb: An Epigenetic Perspective

The authors review currently available information on lead (Pb)-mediated alterations in the fetal epigenome is summarized.
[Journal of Applied Toxicology]
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Gut Microbiota–Derived Metabolite 3-Idoleacetic Acid Together with LPS Induces IL-35+ B Cell Generation

Scientists investigated the regulatory effects of the gut microbiota on IL-35+ cells by using genetically modified mouse models of obesity.
[Microbiome]
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T Cells: Friends and Foes in NASH Pathogenesis and Hepatocarcinogenesis

Scientists review the specific functions of several T cell populations involved in NAFLD and NAFLD-driven HCC.
[Hepatology]
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Oral Cyanobacteria and Hepatocellular Carcinoma

Bacterial 16S rRNA sequences were evaluated in oral samples from 90 hepatocellular carcinoma (HCC) cases and 90 controls who were a part of a larger US case–control study of HCC among patients diagnosed from 2011 to 2016. The authors provides novel evidence that oral Cyanobacteria may be an independent risk factor for HCC.
[Cancer Epidemiology Biomarkers & Prevention]
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C/EBPB-Dependent Adaptation to Palmitic Acid Promotes Tumor Formation in Hormone Receptor Negative Breast Cancer

Scientists demonstrated that obesity-associated tumor formation was driven by cellular adaptation rather than expansion of pre-existing clones within the cancer cell population.
[Nature Communications]
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Molecular Changes in Adipocyte-Derived Stem Cells during Their Interplay with Cervical Cancer Cells

Researchers analyzed the expression profile of adipose tissue-derived stem cells co-cultured with cervical cancer cells through massive RNA sequencing followed by evaluation of various functional alterations resulting from the modified transcriptome.
[Blood Cancer Discovery]
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Using Adipose-Derived Mesenchymal Stem Cells to Fight the Metabolic Complications of Obesity: Where Do We Stand?

Adipose-derived MSC transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
[Obesity Reviews]
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Intestinal Gpr17 Deficiency Improves Glucose Metabolism by Promoting GLP-1 Secretion

Scientists showed that Gpr17, an orphan G protein-coupled receptors, was co-expressed in glucagon-like peptide-1 (GLP-1)-expressing EECs in human and rodent intestinal epithelium.
[Cell Reports]
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Obesity and Biochemical Recurrence in Clinically Localized Prostate Cancer: A Systematic Review and Meta-Analysis of 86,490 Patients

The association of obesity with biochemical recurrence (BCR) after treatment of clinically localized prostate cancer shows inconsistent results. Scientists systematically review all evidence evaluating obesity as a prognostic factor for BCR.
[Prostate Cancer and Prostatic Diseases]
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Diet, Lipids, and Antitumor Immunity

Investigators describe the pro-tumorigenic roles of lipid uptake, metabolism and synthesis and detail the therapeutic potential of targeting lipid metabolism in cancer.
[Cellular & Molecular Immunology]
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An Antisense Transcript Transcribed from Irs2 Locus Contributes to the Pathogenesis of Hepatic Steatosis in Insulin Resistance

Scientists revealed a functional duality of the Irs2 gene locus, where reciprocal changes of Irs2 and ASIrs2 in obesity caused insulin resistance and steatosis.
[Cell Chemical Biology]
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