The authors review currently available information on lead (Pb)-mediated alterations in the fetal epigenome is summarized.
[Journal of Applied Toxicology]
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Tag Archives: obesity
Gut Microbiota–Derived Metabolite 3-Idoleacetic Acid Together with LPS Induces IL-35+ B Cell Generation
Scientists investigated the regulatory effects of the gut microbiota on IL-35+ cells by using genetically modified mouse models of obesity.
[Microbiome]
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T Cells: Friends and Foes in NASH Pathogenesis and Hepatocarcinogenesis
Oral Cyanobacteria and Hepatocellular Carcinoma
Bacterial 16S rRNA sequences were evaluated in oral samples from 90 hepatocellular carcinoma (HCC) cases and 90 controls who were a part of a larger US case–control study of HCC among patients diagnosed from 2011 to 2016. The authors provides novel evidence that oral Cyanobacteria may be an independent risk factor for HCC.
[Cancer Epidemiology Biomarkers & Prevention]
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C/EBPB-Dependent Adaptation to Palmitic Acid Promotes Tumor Formation in Hormone Receptor Negative Breast Cancer
Scientists demonstrated that obesity-associated tumor formation was driven by cellular adaptation rather than expansion of pre-existing clones within the cancer cell population.
[Nature Communications]
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Molecular Changes in Adipocyte-Derived Stem Cells during Their Interplay with Cervical Cancer Cells
Researchers analyzed the expression profile of adipose tissue-derived stem cells co-cultured with cervical cancer cells through massive RNA sequencing followed by evaluation of various functional alterations resulting from the modified transcriptome.
[Blood Cancer Discovery]
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Using Adipose-Derived Mesenchymal Stem Cells to Fight the Metabolic Complications of Obesity: Where Do We Stand?
Adipose-derived MSC transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
[Obesity Reviews]
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Intestinal Gpr17 Deficiency Improves Glucose Metabolism by Promoting GLP-1 Secretion
Scientists showed that Gpr17, an orphan G protein-coupled receptors, was co-expressed in glucagon-like peptide-1 (GLP-1)-expressing EECs in human and rodent intestinal epithelium.
[Cell Reports]
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Obesity and Biochemical Recurrence in Clinically Localized Prostate Cancer: A Systematic Review and Meta-Analysis of 86,490 Patients
The association of obesity with biochemical recurrence (BCR) after treatment of clinically localized prostate cancer shows inconsistent results. Scientists systematically review all evidence evaluating obesity as a prognostic factor for BCR.
[Prostate Cancer and Prostatic Diseases]
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Diet, Lipids, and Antitumor Immunity
Investigators describe the pro-tumorigenic roles of lipid uptake, metabolism and synthesis and detail the therapeutic potential of targeting lipid metabolism in cancer.
[Cellular & Molecular Immunology]
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An Antisense Transcript Transcribed from Irs2 Locus Contributes to the Pathogenesis of Hepatic Steatosis in Insulin Resistance
Scientists revealed a functional duality of the Irs2 gene locus, where reciprocal changes of Irs2 and ASIrs2 in obesity caused insulin resistance and steatosis.
[Cell Chemical Biology]
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