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N6-Methyladenosine Demethylase FTO Suppressed Prostate Cancer Progression by Maintaining CLIC4 mRNA Stability

[Cell Death Discovery] Researchers suggested that fat mass and obesity-associated protein (FTO) suppressed prostate cancer proliferation and metastasis through reducing the degradation of CLIC4 mRNA in an m6A dependent manner.

m6A RNA Demethylase FTO Promotes the Growth, Migration and Invasion of Pancreatic Cancer Cells through Inhibiting TFPI-2

[Epigenetics] Knockdown of fat mass and obesity-related protein (FTO) increased m6A methylation of TFPI-2 mRNA in pancreatic cancer (PC) cells, which increased mRNA stability via the m6A reader YTHDF1, resulting in up-regulation of TFPI-2 expression, and inhibited PC proliferation, colony formation, sphere formation, migration and invasion in vitro.

Tim-3 Expression Causes NK Cell Dysfunction in Type 2 Diabetes Patients

[Frontiers in Immunology] Scientists compared surface receptor expression and cytokine production between peripheral blood NK cells from 90 Type 2 diabetes mellitus patients and 62 age- and sex-matched healthy controls.

IL-37 Isoform D Acts as an Inhibitor of Soluble ST2 to Boost Type 2 Immune Homeostasis in White Adipose Tissue

[Cell Death Discovery] IL-37 isoform D transgene amplified ST2+ immune cells, promoted M2 macrophage polarization and type 2 cytokine secretion in white adipose tissue that mediated beiging and inflammation resolution, thereby increasing energy expenditure, reducing obesity and insulin resistance in high-fat diet-fed mice.

Lessons from Neonatal β-Cell Epigenomic for Diabetes Prevention and Treatment

[Trends in Endocrinology and Metabolism] The authors highlight the importance of studying pancreatic β-cell expansion and functional maturation signaling pathways and epigenetic programs to understand the causes of different forms of diabetes and to permit the design of novel therapeutic strategies.

Sirt6 Reprograms Myofibers to Oxidative Type through CREB-Dependent Sox6 Suppression

[Nature Communications] Scientists reported that Sirt6, an anti-aging histone deacetylase, was critical in regulating myofiber configuration toward oxidative type and that Sirt6 activator could be an exercise mimetic.