Small Molecule Compound M12 Reduces Vascular Permeability in Obese Mice via Blocking Endothelial TRPV4–Nox2 Interaction

The authors showed that interrupting TRPV4–Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.
[Acta Pharmacologica Sinica]
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A Comprehensive Review of the Impact of Obesity on Plasma Cell Disorders

Researchers provide a detailed summary of what is known about the impact of obesity on the pathogenesis of multiple myeloma (MM), its influence on outcomes in MM patients, and discuss potential mechanisms through which obesity is postulated to influence MM risk and prognosis.
[Leukemia]
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ASCs and Their Role in Obesity and Metabolic Diseases

The authors discuss adiposopathy with a focus on adiponiche dysfunction, and underline the mechanisms that control adipose tissue expansion and energy balance.
[Trends in Endocrinology and Metabolism]
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The Molecular Mechanism of Vgf in Appetite, Lipids, and Insulin Regulation

The mechanisms of obesity and diabetes and the crosstalk between these diseases are still ambiguous. The authors clarified and explained the role of VGF peptides in the brain, pancreas, and adipose tissue in the development of obesity.
[Pharmacological Research]
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The Role of Hepatic Lipid Composition in Obesity-Related Metabolic Disease

Scientists summarize cross-sectional human studies using liver biopsy/lipidomics and proton magnetic resonance spectroscopy to characterize hepatic lipid composition in people with obesity and related metabolic disease.
[Liver International]
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Poxel Completes Enrollment in Phase II NASH Trial for PXL065 (DESTINY-1) in Biopsy-Proven Patients

POXEL SA announced the completion of enrollment in DESTINY-1, a dose-ranging Phase II trial evaluating PXL065 for the treatment of non-alcoholic steatohepatitis (NASH).
[POXEL SA]
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A Putative Long Noncoding RNA-Encoded Micropeptide Maintains Cellular Homeostasis in Pancreatic β Cells

Scientists experimentally verified one such micropeptide encoded by a β cell- and neural cell-enriched lncRNA TCL1 upstream neural differentiation-associated RNA. They provided the first evidence that lncRNA-encoded micropeptides played a critical role in pancreatic β cell functions and provided a foundation for future comprehensive analyses of micropeptide function and pathophysiological impact on diabetes.
[Molecular Therapy-Nucleic Acids]
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CohBar Granted US Patent Covering CB4211 Compositions and Use for Treating Nonalcoholic Steatohepatitis (NASH)

CohBar, Inc. announced the United States Patent and Trademark Office has granted a patent, US No. 11,111,271, covering CohBar’s lead candidate CB4211 and related compositions, as well as methods of treatment, including methods of treating NASH.
[CohBar, Inc.]
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Altered Microbiota by a High-Fat Diet Accelerates Lethal Myeloid Hematopoiesis Associated with Systemic Socs3 Deficiency

Although contributing to diet-induced obesity and fatty liver, Suppressors of Cytokine Signaling 3 (SOCS3) was nevertheless critical to suppress excess myeloid hematopoiesis and severe systemic inflammation associated with intestinal dysbiosis on a high-fat diet.
[iScience]
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Autophagy in Metabolic Disease and Aging

Scientists summarize the role of autophagy in the pathogenesis of metabolic diseases associated with or occurring in the context of aging, including insulin resistance, type 2 diabetes mellitus and sarcopenic obesity, and describes its potential as a therapeutic target.
[Nature Reviews Endocrinology]
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Deoxyhypusine Synthase Promotes a Pro-Inflammatory Macrophage Phenotype

Levels of eIF5AHyp were found to be increased in adipose tissue macrophages from obese mice and in murine macrophages activated to a proinflammatory M1-like state.
[Cell Metabolism]
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