Metformin Reduces Saturated Fatty Acid-Induced Lipid Accumulation and Inflammatory Response by Restoration of Autophagic Flux in Endothelial Cells

Incubation of vascular endothelial cells with saturated fatty acid increased the accumulation of lipid droplets and impaired autophagic flux.
[Scientific Reports]
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Neohesperidin Enhances PGC-1α-Mediated Mitochondrial Biogenesis and Alleviates Hepatic Steatosis in High Fat Diet Fed Mice

Neohesperidin (NHP) elevated hepatic mitochondrial biogenesis and fatty acid oxidation by increasing PGC-1α expression. The activation of AMP-activated protein kinase was involved in NHP induced PGC-1α expression.
[FASEB Journal]
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Celastrol Regulates Bone Marrow Mesenchymal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing PGC-1α Signaling

Investigators demonstrated that Celastrol promotes osteoblast differentiation and prevents adipocyte differentiation in bone marrow mesenchymal stem cells in vitro.
[Aging]
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Fatty Acid Mimetic PBI-4547 Restores Metabolic Homeostasis via GPR84 in Mice with Non-Alcoholic Fatty Liver Disease

The authors evaluated the potential of PBI-4547 for the treatment of non-alcoholic fatty liver disease and to validate the role of its main target receptor, G protein-coupled receptor 84 (GPR84).
[Scientific Reports]
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Identification of an Anti-Diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action

In rat cells and in mouse and human islets, SRI-37330 inhibited expression and signaling of thioredoxin-interacting protein, previously found to be elevated in diabetes and to have detrimental effects on islet function.
[Cell Metabolism]
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Gemfibrozil Induces Anemia, Leukopenia and Reduces Hematopoietic Stem Cells via PPAR-α in Mice

Investigators analyzed bone marrow and found that gemfibrozil reduced erythrocytes and hematopoietic stem cells in wild-type mice but not in PPAR-alpha-knockout mice, while increased colony-forming units were observed only in wild-type mice treated with gemfibrozil.
[International Journal of Molecular Sciences]
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NAFLD as a Continuum: From Obesity to Metabolic Syndrome and Diabetes

The authors focus on the clinical and pathophysiological connections between non-alcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes.
[Diabetology & Metabolic Syndrome]
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Myocardial Infarction Accelerates Breast Cancer via Innate Immune Reprogramming

Scientists showed that myocardial infarction accelerates breast cancer outgrowth and cancer-specific mortality in mice and humans.
[Nature Medicine]
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The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

Investigators summarize and question what is known and remains to be discovered about the TREM2 signaling pathway, track the consequences of its activation in physiological niches and pathological contexts, and highlight the promising potential of therapeutic manipulation of TREM2 signaling.
[Cell]
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