Researchers investigated the intracellular mechanism of glucagon-like peptide-1 (GLP-1) synthesis in L cells from the perspective of miRNA. They found that GLP-1 level was down-regulated in the plasma and ileum tissues of obese mice, while the ileac miR-194 expression was up-regulated.
[Cell Death & Disease]
Wang, J., Zhao, D., Ding, C.-Z., Guo, F., Wu, L.-N., Huang, F.-J., Liu, Y.-L., Zhao, S.-Y., Xin, Y., Ma, S.-N., Ji, H.-F., Wang, X., & Wei, L.-R. (2021). MicroRNA-194: a novel regulator of glucagon-like peptide-1 synthesis in intestinal L cells. Cell Death & Disease, 12(1), 1–14. https://doi.org/10.1038/s41419-020-03366-0 Cite
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