hepatic cells

[Hepatology] Scientists found that accompanying with dedifferentiation, long-term cultured ProliHH upregulated a panel of chemokines and cytokines related to innate immunity, which were referred as dedifferentiation-associated inflammatory factors.

[Nature Communications] Researchers identified the tripartite motif-containing protein 31 (Trim31) as an endogenous inhibitor of rhomboid 5 homolog 2 (Rhbdf2), and further determined that Trim31 directly bound to Rhbdf2 and facilitated its proteasomal degradation.

[Pharmacological Research] Scientists found that fibroblast growth factor 18 was markedly upregulated in carbon tetrachloride-induced fibrotic mouse liver tissues and transforming growth factor β stimulated LX-2 cells.

[Toxicology and Applied Pharmacology] The authors determined the role of the 5-HT degradation system in mitochondrial damage and apoptosis of hepatocytes.

[Acta Pharmacologica Sinica] Scientists summarize the current knowledge on the role of bile acids and the receptors in the development of nonalcoholic fatty liver disease and nnonalcoholic steatohepatitis, especially the functions of farnesoid X receptor in different tissues including liver and intestine.

[IUBMB Life] Scientists determined the epigenetic features of the HNF1A gene loci, and expression and cellular localization of HNF1A-AS1 RNA, HNF1A RNA, and HNF1A protein in colorectal cancer and normal colon epithelial cells.