hepatic stellate cells

[Communications Biology] The antifibrotic effect of auranofin was assessed in thioacetamide- and carbon tetrachloride-induced liver fibrosis models. Hepatic stellate cell, bone marrow-derived macrophage, kupffer cell, and hepatocyte were used to examine the underlying mechanism of auranofin.

[Scientific Reports] Researchers clarified the intestinal absorption kinetics of dietary palmitic acid (PA) and the effect of trans-portal PA on the activation of hepatic stellate cells involved in liver fibrosis in nonalcoholic steatohepatitis.

[Hepatology] Multi-cellular hepatocellular carcinoma (HCC) organoid models were established which contained various types of stromal cells, such as hepatic stellate cells, fibroblasts, and endothelial cells together with HCC cells.

[Nature Reviews Molecular Cell Biology] The authors describe the mechanisms of tissue repair following damage, highlighting the close relationship between inflammation and liver regeneration, and discuss how recent findings can help design novel therapeutic approaches.

[Nature] The proteomics studies on liver co-cultures implicated the activated hepatic stellate cells-secreted chemokine CXCL12 in the induction of NK cell quiescence through its cognate receptor CXCR4.

[Scientific Reports] Scientists established liver fibrosis models using multicellular tumor spheroids (MCTSs) composed of hepatocellular carcinoma (HCC) and stromal cells such as fibroblasts (WI38), hepatic stellate cells (LX2), and endothelial cells (HUVEC) seeded at constant ratios.