Researchers clarified the intestinal absorption kinetics of dietary palmitic acid (PA) and the effect of trans-portal PA on the activation of hepatic stellate cells involved in liver fibrosis in nonalcoholic steatohepatitis.
[Scientific Reports]
7753456 8XBWUPTV items 1 apa 0 default asc 1 164010 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d9d2c1313eddd7d4bb727c9fe3dbcf4c%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%228XBWUPTV%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hanayama%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-28%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EHanayama%2C%20M.%2C%20Yamamoto%2C%20Y.%2C%20Utsunomiya%2C%20H.%2C%20Yoshida%2C%20O.%2C%20Liu%2C%20S.%2C%20Mogi%2C%20M.%2C%20Matsuura%2C%20B.%2C%20Takeshita%2C%20E.%2C%20Ikeda%2C%20Y.%2C%20%26amp%3B%20Hiasa%2C%20Y.%20%282021%29.%20The%20mechanism%20of%20increased%20intestinal%20palmitic%20acid%20absorption%20and%20its%20impact%20on%20hepatic%20stellate%20cell%20activation%20in%20nonalcoholic%20steatohepatitis.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%2013380.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-92790-z%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-92790-z%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3D8XBWUPTV%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20mechanism%20of%20increased%20intestinal%20palmitic%20acid%20absorption%20and%20its%20impact%20on%20hepatic%20stellate%20cell%20activation%20in%20nonalcoholic%20steatohepatitis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masakazu%22%2C%22lastName%22%3A%22Hanayama%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasunori%22%2C%22lastName%22%3A%22Yamamoto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hiroki%22%2C%22lastName%22%3A%22Utsunomiya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Osamu%22%2C%22lastName%22%3A%22Yoshida%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shuang%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Masaki%22%2C%22lastName%22%3A%22Mogi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bunzo%22%2C%22lastName%22%3A%22Matsuura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eiji%22%2C%22lastName%22%3A%22Takeshita%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yoshiou%22%2C%22lastName%22%3A%22Ikeda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yoichi%22%2C%22lastName%22%3A%22Hiasa%22%7D%5D%2C%22abstractNote%22%3A%22Dietary%20palmitic%20acid%20%28PA%29%20promotes%20liver%20fibrosis%20in%20patients%20with%20nonalcoholic%20steatohepatitis%20%28NASH%29.%20Herein%2C%20we%20clarified%20the%20intestinal%20absorption%20kinetics%20of%20dietary%20PA%20and%20effect%20of%20trans-portal%20PA%20on%20the%20activation%20of%20hepatic%20stellate%20cells%20%28HSCs%29%20involved%20in%20liver%20fibrosis%20in%20NASH.%20Blood%20PA%20levels%20after%20meals%20were%20significantly%20increased%20in%20patients%20with%20NASH%20compared%20to%20those%20in%20the%20control.%20Expression%20of%20genes%20associated%20with%20fat%20absorption%20and%20chylomicron%20formation%2C%20such%20as%20CD36%20and%20MTP%2C%20was%20significantly%20increased%20in%20the%20intestine%20of%20NASH%20model%20rats%20compared%20with%20that%20in%20the%20controls.%20Plasma%20levels%20of%20glucagon-like%20peptide-2%2C%20involved%20in%20the%20upregulation%20of%20CD36%20expression%2C%20were%20elevated%20in%20NASH%20rats%20compared%20with%20those%20in%20the%20controls.%20Furthermore%2C%20portal%20PA%20levels%20after%20meals%20in%20NASH%20rats%20were%20significantly%20higher%20than%20those%20in%20control%20and%20nonalcoholic%20fatty%20liver%20rats.%20Moreover%2C%20PA%20injection%20into%20the%20portal%20vein%20to%20the%20liver%20in%20control%20rats%20increased%20the%20mRNA%20levels%20associated%20with%20the%20activation%20of%20HSCs.%20Increased%20intestinal%20absorption%20of%20diet-derived%20PA%20was%20observed%20in%20NASH.%20Thus%2C%20the%20rapid%20increase%20in%20PA%20levels%20via%20the%20portal%20vein%20to%20the%20liver%20may%20activate%20HSCs%20and%20affect%20the%20development%20of%20liver%20fibrosis%20in%20NASH.%22%2C%22date%22%3A%222021-06-28%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-92790-z%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-92790-z%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-28T16%3A38%3A56Z%22%7D%7D%5D%7D
Hanayama, M., Yamamoto, Y., Utsunomiya, H., Yoshida, O., Liu, S., Mogi, M., Matsuura, B., Takeshita, E., Ikeda, Y., & Hiasa, Y. (2021). The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis. Scientific Reports, 11(1), 13380. https://doi.org/10.1038/s41598-021-92790-z Cite