hepatitis

[Journal of Experimental Medicine] Investigators found that the frequency of hepatitis B surface antigen (HBsAg)-specific CD8+ T cells was inversely correlated with expansion of monocytic myeloid-derived suppressor cells in young rather than in adult chronic hepatitis B patients.

[DURECT Corporation] DURECT Corporation announced it dosed the first patient in the European Union as part of its AHFIRM randomized, double-blind, placebo-controlled, multi-center Phase IIb study to evaluate the safety and efficacy of larsucosterol in severe alcohol-associated hepatitis. patients.

[Open Biology] Researchers developed a CD8+ T cell and adult stem cell liver organoid system using a microfluidic chip to coculture 3D human liver organoids embedded in extracellular matrix with HLA-matched primary human T cells in suspension.

[Science Immunology] Scientists used multiphoton intravital microscopy in mouse models of hepatitis B to study the intrahepatic behavior of group 1 innate lymphoid cells (ILCs) and their cross-talk with hepatitis B virus–specific CD8+ T cells.

[VBI Vaccines, Inc.] VBI Vaccines, Inc. announced that the European Medicines Agency’s Committee for Medicinal Products for Human use (CHMP) has adopted a positive opinion for VBI’s 3-antigen hepatitis B vaccine, under the brand name PreHevbri™.

[Communications Biology] The authors reported the identification of hepatitis C virus NS5A inhibitors Pibrentasvir and Ombitasvir as SARS-CoV-2 exonuclease inhibitors.