hepatocytes

[Scientific Reports] The authors investigated miR1908-5p function by leveraging human primary hepatocytes and HuH-7 hepatoma models and implicated miR1908-5p in metabolic and energy regulation in hepatocyte models via multiple, independent, pathways.

[Biomaterials] Human primary hepatocyte organoids and HepaRG spheroids showed more mature hepatocyte phenotype after adding fibronectin and fibrinogen to the culture system.

[PLoS One] Scientists characterized hepatic stellate cells obtained from patients carrying the wild type and the heterozygous or homozygous PNPLA3 I148M and investigated the effect of genotype and PNPLA3 downregulation on baseline and TGF-β-stimulated fibrotic gene expression.

[Stem Cell Reports] Investigators established a robotic platform and automated all essential steps of human iPSC culture and differentiation under chemically defined conditions.

[Hepatology] The authors invevstigated whether farnesoid X receptor (FXR) played a role in regulating iron hepatotoxicity and found that iron suppressed FXR expression and signaling in human and mouse hepatocytes as well as in mouse liver and intestine.

[NPJ Regenerative Medicine] The authors suggested that mesenchymal stromal cells ameliorated surgery-induced hepatocellular stress and epithelial-mesenchymal transition, thus supporting epithelial integrity and facilitating regeneration.