hepatocytes

[Journal of Hepatology] Scientists investigated the role of Sox9, a transcription factor downstream of Yap activation and expressed in biliary epithelial cells (BECs), in Yap-induced cell fate plasticity during hepatocarcinogenesis.

[Journal of Hepatology] Investigators provide a description of several key mechanisms that contribute to lipid droplet accumulation in the hepatocytes, favouring non-alcoholic fatty liver disease (NAFLD) progression.

[Science Signaling] TRβ1 and its principal corepressor NCoR1 in hepatocytes repressed de novo lipogenesis, whereas the TH-mediated induction of lipogenic genes depended on the transcription factor ChREBP.

[Cell Reports] Scientists investigated the role of TM4SF5 in communication between hepatocytes and macrophages and its possible influence on the inflammatory microenvironment that may lead to nonalcoholic fatty liver disease.

[iScience] Investigators implicated that glucosylceramide accumulation was one of triggers promoting the development of nonalcoholic fatty liver disease into non-alcoholic steatohepatitis, then, fibrosis and tumorigenesis.

[Journal of Cellular and Molecular Medicine] Researchers demonstrated that mesenchymal–epithelial transition (MET) inhibition enhanced sensitivity of CRPC to poly adenosine diphosphate–ribose polymerase (PARP) inhibitors by suppressing the ATM/ATR and phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathways.