hepatocytes

[Nature] Scientists analyzed somatic mutations from 1,590 genomes across 34 liver samples, including healthy controls, alcohol-related liver disease and non-alcoholic fatty liver disease. Seven of the 29 patients with liver disease had mutations in FOXO1, the major transcription factor in insulin signaling.

[Scientific Reports] The authors reported the successful generation of 3D thermally crosslinked preforms by using solution blow spinning (SBS) from porcine gelatin. They then used SBS mats as culturing substrates for human hepatocytes to create an array of 3D human liver tissue equivalents in 96-well format.

[Scientific Reports] Scientists aimed to establish a new type of rapid liver hyperplasia model induced mainly by bile acid pathway through hepatoenteral circulation with hilar bile duct ligation. Immunohistochemistry results confirmed the proliferation of hepatocytes in the unligated liver lobe.

[Cell Discovery] Liver-specific Sirutin 2 (SIRT2) deficiency sensitized mice to alcoholic liver disease, whereas transgenic SIRT2 overexpression in hepatocytes significantly prevented ethanol-induced liver injury via normalization of hepatic steatosis, lipid peroxidation, and hepatocyte apoptosis.

[Blood] Scientists generated three lines of transgenic mice with graded erythroid overexpression of erythroferrone and showed that they developed dose-dependent iron overload, impaired hepatic BMP signaling and relative hepcidin deficiency.

[Gut] Cholestatic and non-alcoholic fatty liver disease share several key pathophysiological mechanisms which can be targeted by novel therapeutic concepts that are currently developed for both areas.