Panobinostat Reverses HepaCAM Gene Expression and Suppresses Proliferation by Increasing Histone Acetylation in Prostate Cancer

Scientists investigated the effect of panobinostat, the broad-spectrum histone deacetylases inhibitor, on prostate cancer LNCaP and DU145 cell growth, and observed re-expression of hepatocyte cell adhesion molecule when treated with panobinostat.
[Gene]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

HIF-1 Recruits NANOG as a Coactivator for TERT Gene Transcription in Hypoxic Breast Cancer Stem Cells

Investigators showed that hypoxia-inducible factor 1α (HIF-1α) is required for NANOG-mediated breast CSC enrichment.
[Cell Reports]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Chromatin Remodeling Due to Degradation of Citrate Carrier Impairs Osteogenesis of Aged Mesenchymal Stem Cells

Researchers showed that aged mesenchymal stem cells exhibited reduced chromatin accessibility and lowered histone acetylation, particularly on promoters and enhancers of osteogenic genes.
[Nature Aging]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Mitogen-Activated Protein Kinase Signaling in Childhood Asthma Development and Environment-Mediated Protection

Scientists aimed to investigate the role of MAPK signaling in childhood asthma and its environment-mediated protection, including a representative selection of 232 out of 1062 children from two cross-sectional cohorts and one birth cohort study.
[Pediatric Allergy and Immunology]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

CHFR Regulates Chemoresistance in Triple-Negative Breast Cancer through Destabilizing ZEB1

Integrated affinity purification combined with mass spectrometry and TCGA analysis identified a cell cycle-related E3 ubiquitin ligase, checkpoint with forkhead and ring finger domains (CHFR), as a key negative regulator of zinc finger E-box-binding homeobox 1 (ZEB1) in TNBC.
[Cell Death & Disease]
[zotpress userid=’7992332′ items=’BYCHSBFF’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Epigenetic Control of Melanoma Cell Invasiveness by the Stem Cell Factor SALL4

Transcriptional profiling and in vitro assays using human melanoma cells demonstrated that SALL4 loss induced a phenotype switch and the acquisition of an invasive phenotype.
[Nature Communications]
[zotpress userid=” items=’XTVA5EDI’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Aspirin Enhances the Therapeutic Efficacy of Cisplatin in Oesophageal Squamous Cell Carcinoma by Inhibition of Putative Cancer Stem Cells

The authors investigated the role of acetylsalicylic acid in chemotherapy/chemoprevention in human oesophageal squamous cell carcinoma (ESCC) cell lines and an N-nitrosomethylbenzylamine-induced rat ESCC carcinogenesis model.
[British Journal of Cancer]
[zotpress userid=” items=’7Z39ANTE’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Bromodomain-Containing Protein BRPF1 Is a Therapeutic Target for Liver Cancer

Gene ablation or pharmacological inactivation of BRPF1 (bromodomain and PHD finger containing 1) significantly attenuated hepatocellular carcinoma cell growth in vitro and in vivo.
[Communications Biology]
[zotpress userid=” items=’GPARQPAM’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

NEU4 Inhibits Motility of HCC Cells by Cleaving Sialic Acids on CD44

Scientists found the NEU4 expression was significantly down-regulated in hepatocellular carcinoma (HCC) tissues, which was correlated with high grades and poor outcomes of HCC.
[Oncogene]
[zotpress userid=” items=’E4EA5H99′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

TCF1 in T Cell Immunity: A Broadened Frontier

Scientists summarize the key findings on TCF1 across the fields of T cell immunity and reflect on the possibility of exploring TCF1 and its downstream transcriptional programmes as therapeutic targets for improving antiviral and antitumour immunity.
[Nature Reviews Immunology]
[zotpress userid=’6445218′ items=’SPGJUG6Q’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Histone Deficiency and Accelerated Replication Stress in T Cell Aging

Scientists showed that naive T cells from older individuals as well as miR-181ab1–deficient murine T cells develop excessive replication stress after activation, due to reduced histone expression and delayed S-phase cell cycle progression.
[Journal of Clinical Investigation]
[zotpress userid=’6445218′ items=’AAW2GWZV’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share
Share