Scientists report that HDAC11 was highly expressed in hepatocellular carcinoma and was closely related to disease prognosis. Depletion of HDAC11 in a conditional knockout mouse model reduced hepatocellular tumorigenesis and prolonged survival.
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Bi, L., Ren, Y., Feng, M., Meng, P., Wang, Q., Chen, W., Jiao, Q., Wang, Y., Du, L., Zhou, F., Jiang, Y., Chen, F., Wang, C., Tang, B., & Wang, Y. (2021). HDAC11 regulates glycolysis through the LKB1/AMPK signaling pathway to maintain hepatocellular carcinoma stemness. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-3044 Cite