On-Going Consequences of In Utero Exposure of Pb: An Epigenetic Perspective

The authors review currently available information on lead (Pb)-mediated alterations in the fetal epigenome is summarized.
[Journal of Applied Toxicology]
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Altered H3 Histone Acetylation Impairs High-Fidelity DNA Repair to Promote Cerebellar Degeneration in Spinocerebellar Ataxia Type 7

Scientists performed chromatic immunoprecipitation sequencing ChIP-seq on cerebellum from spinocerebellar ataxia type 7 mice and observed increased H3K9-promoter acetylation in DNA repair genes, resulting in increased expression.
[Cell Reports]
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BAF Complexes Drive Proliferation and Block Myogenic Differentiation in Fusion-Positive Rhabdomyosarcoma

Investigators investigated the contributions of chromatin regulatory complexes to fusion positive RMS (FP-RMS) tumor maintenance. They defined the mSWI/SNF functional repertoire in FP-RMS.
[Nature Communications]
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MAP2K6 Remodels Chromatin and Facilitates Reprogramming by Activating Gatad2b-Phosphorylation Dependent Heterochromatin Loosening

The authors identified mitogen-activated protein kinase kinase 6 as a chromatin relaxer and found that it could significantly enhance reprogramming.
[Cell Death & Differentiation]
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Lactate Supports a Metabolic-Epigenetic Link in Macrophage Polarization

Investigators reported that interleukin-4 –induced M0 → M2 macrophage polarization was accompanied by interchangeable glucose- or lactate-dependent tricarboxylic acid cycle metabolism that directly drove histone acetylation, M2 gene transcription, and functional immune suppression.
[Science Advances]
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Panobinostat Reverses HepaCAM Gene Expression and Suppresses Proliferation by Increasing Histone Acetylation in Prostate Cancer

Scientists investigated the effect of panobinostat, the broad-spectrum histone deacetylases inhibitor, on prostate cancer LNCaP and DU145 cell growth, and observed re-expression of hepatocyte cell adhesion molecule when treated with panobinostat.
[Gene]
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HIF-1 Recruits NANOG as a Coactivator for TERT Gene Transcription in Hypoxic Breast Cancer Stem Cells

Investigators showed that hypoxia-inducible factor 1α (HIF-1α) is required for NANOG-mediated breast CSC enrichment.
[Cell Reports]
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Chromatin Remodeling Due to Degradation of Citrate Carrier Impairs Osteogenesis of Aged Mesenchymal Stem Cells

Researchers showed that aged mesenchymal stem cells exhibited reduced chromatin accessibility and lowered histone acetylation, particularly on promoters and enhancers of osteogenic genes.
[Nature Aging]
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Mitogen-Activated Protein Kinase Signaling in Childhood Asthma Development and Environment-Mediated Protection

Scientists aimed to investigate the role of MAPK signaling in childhood asthma and its environment-mediated protection, including a representative selection of 232 out of 1062 children from two cross-sectional cohorts and one birth cohort study.
[Pediatric Allergy and Immunology]
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CHFR Regulates Chemoresistance in Triple-Negative Breast Cancer through Destabilizing ZEB1

Integrated affinity purification combined with mass spectrometry and TCGA analysis identified a cell cycle-related E3 ubiquitin ligase, checkpoint with forkhead and ring finger domains (CHFR), as a key negative regulator of zinc finger E-box-binding homeobox 1 (ZEB1) in TNBC.
[Cell Death & Disease]
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Epigenetic Control of Melanoma Cell Invasiveness by the Stem Cell Factor SALL4

Transcriptional profiling and in vitro assays using human melanoma cells demonstrated that SALL4 loss induced a phenotype switch and the acquisition of an invasive phenotype.
[Nature Communications]
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