HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness

Scientists report that HDAC11 was highly expressed in hepatocellular carcinoma and was closely related to disease prognosis. Depletion of HDAC11 in a conditional knockout mouse model reduced hepatocellular tumorigenesis and prolonged survival.
[Cancer Research]
Bi, L., Ren, Y., Feng, M., Meng, P., Wang, Q., Chen, W., Jiao, Q., Wang, Y., Du, L., Zhou, F., Jiang, Y., Chen, F., Wang, C., Tang, B., & Wang, Y. (2021). HDAC11 regulates glycolysis through the LKB1/AMPK signaling pathway to maintain hepatocellular carcinoma stemness. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-3044 Cite
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Astrocytic ApoE Reprograms Neuronal Cholesterol Metabolism and Histone-Acetylation-Mediated Memory

The authors demonstrated that astrocytic ApoE vectors a variety of miRNAs, and these miRNAs specifically silence genes involved in neuronal cholesterol biosynthesis, ultimately accounting for accumulation of the pathway-initiating substrate acetyl-CoA.
[Neuron]
Li, X., Zhang, J., Li, D., He, C., He, K., Xue, T., Wan, L., Zhang, C., & Liu, Q. (2021). Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory. Neuron, 0(0). https://doi.org/10.1016/j.neuron.2021.01.005 Cite
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The PWWP2A Histone Deacetylase Complex Represses Intragenic Spurious Transcription Initiation in mESCs

Scientists used CAGE-seq to profile all transcription initiation sites in wildtype mouse (m)ESCs and cells lacking PWWP2A/B. Loss of PWWP2A/B enhances spurious initiation from intragenic sites present in wildtype mESCs, and this effect is associated with increased levels of initiating Pol-II and histone acetylation.
[iScience]
Wei, G., Brockdorff, N., & Zhang, T. (2020). The PWWP2A Histone Deacetylase Complex Represses Intragenic Spurious Transcription Initiation in mESCs. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101741 Cite
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An Embryonic Stem Cell-Specific Heterochromatin State Promotes Core Histone Exchange in the Absence of DNA Accessibility

Loss of H3.3 in mouse ESCs elicited a highly specific opening of interstitial heterochromatin with minimal effects on other silent or active regions of the genome.
[Nature Communications]
Navarro, C., Lyu, J., Katsori, A.-M., Caridha, R., & Elsässer, S. J. (2020). An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility. Nature Communications, 11(1), 5095. https://doi.org/10.1038/s41467-020-18863-1 Cite
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PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells

Researchers report the histone acetyltransferase PCAF as a fork-associated protein that promotes fork degradation in BRCA-deficient cells by acetylating H4K8 at stalled replication forks, which recruits MRE11 and EXO1.
[Molecular Cell]
Kim, J. J., Lee, S. Y., Choi, J.-H., Woo, H. G., Xhemalce, B., & Miller, K. M. (2020). PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells. Molecular Cell, 0(0). https://doi.org/10.1016/j.molcel.2020.08.018 Cite
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Glis1 Facilitates Induction of Pluripotency via an Epigenome–Metabolome–Epigenome Signaling Cascade

Scientists highlighted Glis1 as a powerful reprogramming factor, and revealed an epigenome–metabolome–epigenome signaling cascade that involved the glycolysis-driven coordination of histone acetylation and lactylation in the context of cell fate determination.
[Nature Metabolism]
Li, L., Chen, K., Wang, T., Wu, Y., Xing, G., Chen, M., Hao, Z., Zhang, C., Zhang, J., Ma, B., Liu, Z., Yuan, H., Liu, Z., Long, Q., Zhou, Y., Qi, J., Zhao, D., Gao, M., Pei, D., … Liu, X. (2020). Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade. Nature Metabolism, 1–11. https://doi.org/10.1038/s42255-020-0267-9 Cite
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Glycolysis Links Reciprocal Activation of Myeloid Cells and Endothelial Cells in the Retinal Angiogenic Niche

Scientists showed that in the pathological angiogenic vascular niche, retinal myeloid cells, particularly macrophages/microglia that were spatially adjacent to endothelial cells, were highly glycolytic.
[Science Translational Medicine]
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