Histone Modifications Centric-Regulation in Osteogenic Differentiation

Investigators improve the understanding of the role of histone modifications in osteogenic differentiation and describe its potential as a therapeutic target for osteogenic differentiation-related diseases.
[Cell Death Discovery]
Li, K., Han, J., & Wang, Z. (2021). Histone modifications centric-regulation in osteogenic differentiation. Cell Death Discovery, 7(1), 1–8. https://doi.org/10.1038/s41420-021-00472-6 Cite
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Arginine Is an Epigenetic Regulator Targeting TEAD4 to Modulate OXPHOS in Prostate Cancer Cells

The authors showed in prostate cancer cells that arginine acted as an epigenetic regulator to modulate histone acetylation, leading to global upregulation of nuclear-encoded oxidative phosphorylation (OXPHOS) genes.
[Nature Communications]
Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells | Nature Communications. (n.d.). Retrieved April 23, 2021, from https://www.nature.com/articles/s41467-021-22652-9 Cite
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P300/CBP Inhibition Sensitizes Mantle Cell Lymphoma to PI3Kδ Inhibitor Idelalisib

Scientists report that a p300/CBP inhibitor, A-485, could overcome resistance to idelalisib in mantle cell lymphoma cells in vitro and in vivo.
[Acta Pharmacologica Sinica]
Zhou, X., Li, X., Liao, L., Han, J., Huang, J., Li, J., Tao, H., Fan, S., Chen, Z., Li, Q., Chen, S., Ding, H., Yang, Y., Zhou, B., Jiang, H., Chen, K., Zhang, Y., Huang, C., & Luo, C. (2021). P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib. Acta Pharmacologica Sinica, 1–13. https://doi.org/10.1038/s41401-021-00643-2 Cite
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H3K9ac of TGFβRI in Human Umbilical Cord: A Potential Biomarker for Evaluating Cartilage Differentiation and Susceptibility to Osteoarthritis via a Two-Step Strategy

Two kinds of Wharton’s jelly-MSCs were applied to evaluate their chondrogenic potential in vitro through inducing chondrogenic differentiation as the first step of our strategy, one from newborns with intrauterine growth retardation (IUGR) and the other from normal newborns but treated with excessive cortisol during differentiation to simulate the excessive maternal glucocorticoid in the IUGR newborns.
[Stem Cell Research & Therapy]
Qi, Y., Li, B., Wen, Y., Yang, X., Chen, B., He, Z., Zhao, Z., Magdalou, J., Wang, H., & Chen, L. (2021). H3K9ac of TGFβRI in human umbilical cord: a potential biomarker for evaluating cartilage differentiation and susceptibility to osteoarthritis via a two-step strategy. Stem Cell Research & Therapy, 12(1), 163. https://doi.org/10.1186/s13287-021-02234-8 Cite
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A Hierarchical and Collaborative BRD4/CEBPD Partnership Governs Vascular Smooth Muscle Cell Inflammation

Scientists investigated their interplay in vascular smooth muscle cell inflammation. Chromatin immunoprecipitation followed by high-throughput sequencing revealed H3K27ac/BRD4 enrichment at CCAAT enhancer binding protein delta (Cebpd) in injured rat carotid arteries.
[Molecular Therapy-Methods & Clinical Development]
Wang, Q., Ozer, H. G., Wang, B., Zhang, M., Urabe, G., Huang, Y., Kent, K. C., & Guo, L.-W. (2021). A hierarchical and collaborative BRD4/CEBPD partnership governs vascular smooth muscle cell inflammation. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2021.02.021 Cite
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HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness

Scientists report that HDAC11 was highly expressed in hepatocellular carcinoma and was closely related to disease prognosis. Depletion of HDAC11 in a conditional knockout mouse model reduced hepatocellular tumorigenesis and prolonged survival.
[Cancer Research]
Bi, L., Ren, Y., Feng, M., Meng, P., Wang, Q., Chen, W., Jiao, Q., Wang, Y., Du, L., Zhou, F., Jiang, Y., Chen, F., Wang, C., Tang, B., & Wang, Y. (2021). HDAC11 regulates glycolysis through the LKB1/AMPK signaling pathway to maintain hepatocellular carcinoma stemness. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-3044 Cite
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Astrocytic ApoE Reprograms Neuronal Cholesterol Metabolism and Histone-Acetylation-Mediated Memory

The authors demonstrated that astrocytic ApoE vectors a variety of miRNAs, and these miRNAs specifically silence genes involved in neuronal cholesterol biosynthesis, ultimately accounting for accumulation of the pathway-initiating substrate acetyl-CoA.
[Neuron]
Li, X., Zhang, J., Li, D., He, C., He, K., Xue, T., Wan, L., Zhang, C., & Liu, Q. (2021). Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory. Neuron, 0(0). https://doi.org/10.1016/j.neuron.2021.01.005 Cite
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The PWWP2A Histone Deacetylase Complex Represses Intragenic Spurious Transcription Initiation in mESCs

Scientists used CAGE-seq to profile all transcription initiation sites in wildtype mouse (m)ESCs and cells lacking PWWP2A/B. Loss of PWWP2A/B enhances spurious initiation from intragenic sites present in wildtype mESCs, and this effect is associated with increased levels of initiating Pol-II and histone acetylation.
[iScience]

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An Embryonic Stem Cell-Specific Heterochromatin State Promotes Core Histone Exchange in the Absence of DNA Accessibility

Loss of H3.3 in mouse ESCs elicited a highly specific opening of interstitial heterochromatin with minimal effects on other silent or active regions of the genome.
[Nature Communications]

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PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells

Researchers report the histone acetyltransferase PCAF as a fork-associated protein that promotes fork degradation in BRCA-deficient cells by acetylating H4K8 at stalled replication forks, which recruits MRE11 and EXO1.
[Molecular Cell]
Kim, J. J., Lee, S. Y., Choi, J.-H., Woo, H. G., Xhemalce, B., & Miller, K. M. (2020). PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells. Molecular Cell, 0(0). https://doi.org/10.1016/j.molcel.2020.08.018 Cite
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Glis1 Facilitates Induction of Pluripotency via an Epigenome–Metabolome–Epigenome Signaling Cascade

Scientists highlighted Glis1 as a powerful reprogramming factor, and revealed an epigenome–metabolome–epigenome signaling cascade that involved the glycolysis-driven coordination of histone acetylation and lactylation in the context of cell fate determination.
[Nature Metabolism]

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