induced pluripotent stem cells

[Cell] Researchers showed that frontotemporal dementia mutations impaired bioenergetics and markedly diminished Tau’s interaction with mitochondria proteins, which were downregulated in Alzheimer disease brains of multiple cohorts and correlated with disease severity.

[eLife] Skeletal muscle myoblasts (iMyoblasts) were generated from human iiPSCs using an efficient and reliable transgene-free induction and stem cell selection protocol.

[Development] The authors suggested that Djplac8-A acted as a molecular switch of piwi+ stem cells for entry into the regenerative state after amputation.

[Stem Cell Reports] Researchers described a high-efficiency reprogramming of human somatic cells into iPSCs using optimized CRISPR activation.

[Scientific Reports] Scientists found that enrichment of common organic matrices by black phosphorus could improve discrimination data analysis by enhancing peak intensity and reproducibility of mass spectra acquired from intact cells.

[Pluristyx, Inc.] Pluristyx, Inc., panCELLa, and Implant Therapeutics announced they have entered into a manufacturing and distribution strategic alliance that offers cell therapy companies streamlined access to the next generation of safe, universal, cost-effective, “off-the-shelf” iPSCs.