induced pluripotent stem cells

[Development] By applying outer plexiform layer (OPL) staging criteria to human retinal organoids derived from human embryonic and iPSC, scientists observed comparable maturation from OPL-Stage 0 at day 100 in culture up to OPL-Stage 3 by day 160.

[Journal of Molecular Biology] The advent of brain organoid technology has provided a new means to study the cause and progression of developmental brain diseases in vitro.

[Nature Communications] Investigators established a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons.

[AgeX Therapeutics, Inc.] AgeX Therapeutics, Inc. announced today a research collaboration with the University of California, Irvine to explore the therapeutic potential of exosomes and other extracellular vesicles produced by neural stem cells derived from AgeX pluripotent stem cells, with the goal of developing therapies to treat adverse neurocognitive effects of cancer chemotherapy and radiation therapy on brain function.

[Archivum Immunologiae et therapiae Experimentalis] Scientists review some of the emerging strategies in use to engineer CAR-expressing iPSC-derived drug products.

[Acta Biomaterialia] The authors bioengineered a physiologically relevant 3D scaffold by integrating brain-like extracellular matrix components and chemical cues.