induced pluripotent stem cells

[Nature Protocols] Researchers provided a detailed protocol describing how to form heart-forming organoids within 14 days, that could be used on many different human PSC lines and be combined with manipulation technologies such as gene targeting and drug testing.

[Nature Communications] The authors introduced a method that simultaneously measured protein expression and thermal stability changes in cells and provided the web-based visualization tool ProteoTracker, and applied their method to study differences between human PSCs and several cell types.

[Stem Cell Reports] The authors highlight an important regulatory role for DPPA2 and DPPA4 at the transitional boundary between pluripotency and differentiation their relevance to the functions of DPPA2 and 4 in the context of cancer cells as well.

[Cancer Letters] The authors address the noncanonical roles of p53 and their implications in sarcoma initiation and progression.

[Toxicology and Applied Pharmacology] Scientists used human iPSC-derived embryoid bodies as an in vitro model to investigate the embryotoxic effects of a carefully selected set of pharmacological compounds.

[Nanomedicine-Nanotechnology Biology and Medicine] Investigators proposed thin films of functionalized carbon nanotubes as alternatives for the feeder-free in vitro culture of canine iPSCs, considered as the cellular model.