induced pluripotent stem cells

[Translational Psychiatry] Researchers generated iPSCs from patients with familial schizophrenia, differentiated these cells into neurons, and investigated the molecular and cellular phenotypes of the patient’s neurons.

[Stem Cell Reviews and Reports] Scientists differentiated human amniotic fluid-derived iPSCs into a mixed population of neurons. Functional assessments were performed by evaluating electrophysiological properties and the effect of a panel of neuropharmacological agents on spontaneous activity.

[Nature Neuroscience] Researchers reported the development of a cerebral organoid slice model derived from human induced pluripotent stem cells that recapitulated mature cortical architecture and displayed early molecular pathology of C9ORF72 ALS/FTD.

[Stem Cell Reports] Researchers generated micropatterned colonies of iPSCs to test whether non-synonymous single nucleotide variants (nsSNVs) influenced patterning of radially ordered germ layers.

[Stem Cell Reports] Scientists generated patient-derived CALRins5- or CALRdel52-positive iPSCs to establish a myeloproliferative neoplasms disease model for molecular and mechanistic studies.

[Stem Cell Reports] The authors review proposed mutations in the recipient embryo to disable hepatogenesis, and discuss the advantages of using fumarylacetoacetate hydrolase knockouts and other genetic modifications to disable hepatogenesis.