induced pluripotent stem cells

[Annual Review of Biomedical Engineering] Investigators examine the body of literature that encompasses microfluidic applications where human iPSCs are derived starting from human somatic cells and where human pluripotent stem cells are differentiated into different cell types.

[Birth Defects Research] The authors review how Oct4 is regulated in pluripotent stem cells, and address some of the gaps in knowledge about regulation of the pluripotency network in neural crest cells.

[Stem Cell Reports] Scientists report successful targeting of the CCR5 locus in iPSCs generated from T cells or fibroblasts from Mauritian cynomolgus macaques, using CRISPR-Cas9 technology.

[Trends in Molecular Medicine] Ophthalmologists are now working closely with basic researchers to incorporate new technology areas with a synergy that is anticipated to realize the practical application of stem cell-based therapy for retinal degeneration.

[Stem Cell Reports] Scientists performed molecular dynamic simulations to determine the effect of missense variant rs2229774 on retinoic acid receptor gamma (RARG) structure and then validated these predictions using CRISPR-Cas9-genome-edited, induced pluripotent stem cell-derived cardiomyocytes.

[Scientific Data] Researchers presented a dataset of microelectrode array recordings from hPSC-derived and rat embryonic cortical neurons during their in vitro maturation.