RARG S427L Attenuates the DNA Repair Response to Doxorubicin in Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Scientists performed molecular dynamic simulations to determine the effect of missense variant rs2229774 on retinoic acid receptor gamma (RARG) structure and then validated these predictions using CRISPR-Cas9-genome-edited, induced pluripotent stem cell-derived cardiomyocytes.