hsa_circNFXL1_009 Modulates Apoptosis, Proliferation, Migration, and Potassium Channel Activation in Pulmonary Hypertension

The authors explored the circular RNA profile in pulmonary arterial hypertension patients caused by chronic obstructive pulmonary disease and the effects of hsa_circNFXL1_009 on abnormal proliferation, apoptosis, and migration of human pulmonary arterial smooth muscle cells driven by hypoxia.
[Molecular Therapy-Nucleic Acids]
Jin, X., Xu, Y., Guo, M., Sun, Y., Ding, J., Li, L., Zheng, X., Li, S., Yuan, D., & Li, S.-S. (2020). hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.09.029 Cite
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miR-27a-3p Targets ATF3 to Reduce Calcium Deposition in Vascular Smooth Muscle Cells

Scientists report that reduction of microRNA-27a-3p causes an increase in ATF3, activating transcription factor 3, a novel osteogenic transcription factor, in vascular smooth muscle cells.
[Molecular Therapy-Nucleic Acids]
Choe, N., Kwon, D.-H., Ryu, J., Shin, S., Cho, H. J., Joung, H., Eom, G. H., Ahn, Y., Park, W. J., Nam, K.-I., Kim, Y.-K., & Kook, H. (2020). miR-27a-3p targets ATF3 to reduce calcium deposition in vascular smooth muscle cells. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.09.030 Cite
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12-O-Tetradecanoylphorbol-13-Acetate Increases Cardiomyogenesis through PKC/ERK Signaling

Scientists showed that 12-O-tetradecanoylphorbol-13-acetate can be applied as a cardiomyogenesis-promoting factor for the differentiation of mouse embryonic stem cells in vitro.
[Scientific Reports]
Radaszkiewicz, K. A., Beckerová, D., Woloszczuková, L., Radaszkiewicz, T. W., Lesáková, P., Blanářová, O. V., Kubala, L., Humpolíček, P., & Pachernik, J. (2020). 12-O-Tetradecanoylphorbol-13-acetate increases cardiomyogenesis through PKC/ERK signaling. Scientific Reports, 10(1), 15922. https://doi.org/10.1038/s41598-020-73074-4 Cite
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Autophagy and Cardiac Diseases: Therapeutic Potential of Natural Products

The authors focus on the role of autophagy in various cardiac diseases and the pharmacological basis and therapeutic potential of reported natural products in cardiac diseases by modifying autophagic processes.
[Medicinal Research Reviews]
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SARS-CoV-2 Infects and Induces Cytotoxic Effects in Human Cardiomyocytes

The authors demonstrated that SARS-CoV-2 infects cardiomyocytes in vitro in an ACE2- and cathepsin-dependent manner.
[Cardiovascular Research]
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LRP6 Downregulation Promotes Cardiomyocyte Proliferation and Heart Regeneration

Researchers investigated the role of lipoprotein receptor-related protein 6 (LRP6) in heart repair through regulation of cardiomyocyte proliferation. Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal, juvenile and adult mice.
[Cell Research]
Wu, Y., Zhou, L., Liu, H., Duan, R., Zhou, H., Zhang, F., He, X., Lu, D., Xiong, K., Xiong, M., Zhuang, J., Liu, Y., Li, L., Liang, D., & Chen, Y.-H. (2020). LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration. Cell Research, 1–13. https://doi.org/10.1038/s41422-020-00411-7 Cite
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Transplanted Microvessels Improve Pluripotent Stem Cell–Derived Cardiomyocyte Engraftment and Cardiac Function after Infarction in Rats

Ready-made microvessels promoted a sixfold increase in human induced pluripotent stem cell–derived cardiomyocyte (hiPSC-CM) survival and superior functional recovery when compared to hiPSC-CMs transplanted alone or cotransplanted with a suspension of dissociated endothelial cells in infarcted rat hearts.
[Science Translational Medicine]
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Circular RNA CDR1as Promotes Pulmonary Artery Smooth Muscle Cell Calcification by Upregulating CAMK2D and CNN3 via Sponging miR-7-5p

Scientists investigated the implication and regulatory effect of a typical circular RNA, CDR1as, in the pathological process of vascular calcification in pulmonary hypertension.
[Molecular Therapy-Nucleic Acids]
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Transcriptomic Profiling of Human Cardiac Cells Predicts Protein Kinase Inhibitor-Associated Cardiotoxicity

Investigators obtained transcriptional profiles of human heart-derived primary cardiomyocyte like cell lines treated with a panel of 26 FDA-approved kinase inhibitors and classified their effects on subcellular pathways and processes.
[Nature Communications]
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Single-Cell Genomics Reveals a Novel Cell State during Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human

To reveal the trajectories of smooth muscle cell (SMC) transdifferentiation during atherosclerosis and to identify molecular targets for disease therapy, researchers combined SMC fate mapping and single-cell RNA sequencing of both mouse and human atherosclerotic plaques.
[Circulation]
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BCAT1 Binds the RNA-Binding Protein ZNF423 to Activate Autophagy via the IRE1-XBP-1-RIDD Axis in Hypoxic PASMCs

Scientists discovered that BCAT1 bound IRE1 on the endoplasmic reticulum to activate expression of its downstream pathway XBP-1-RIDD axis to activate autophagy. They identified an RNA-binding protein, zinc finger protein 423, which promoted autophagy by binding adenylate/uridylate-rich elements in the BCAT1 mRNA 3′-untranslated region.
[Cell Death & Disease]
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