Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart

The authors showed for the first time that the immune response is altered as a result of syngeneic neonatal cardiomyocyte transplantation after myocardial infarction leading to improved cardiac pump function as observed by magnetic resonance imaging in C57BL/6J mice.
[Cells]
Vasudevan, P., Wolfien, M., Lemcke, H., Lang, C. I., Skorska, A., Gaebel, R., Koczan, D., Lindner, T., Engelmann, R., Vollmar, B., Krause, B. J., Wolkenhauer, O., Lang, H., Steinhoff, G., & David, R. (2020). Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart. Cells, 9(8), 1825. https://doi.org/10.3390/cells9081825 Cite
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Exosomes — Beyond Stem Cells for Cardiac Protection and Repair

Scientists discuss the therapeutic benefit of exosomes secreted by stem and progenitor cells in preclinical models of ischemic heart disease.
[Stem Cells]
Balbi, C., & Vassalli, G. (n.d.). Exosomes — Beyond Stem Cells for Cardiac Protection and Repair. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3261 Cite
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Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Investigators showed that berberine administration markedly ameliorated intralipid-induced insulin resistance without affecting blood glucose. They used human skeletal muscle cells, hepatocytes, human umbilical vein endothelial cells, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
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Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
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Enhancing Myocardial Repair with CardioClusters

Mesenchymal stem cells, endothelial progenitor cells and c-Kit+ cardiac interstitial cells when cultured together spontaneously formed scaffold-free 3D microenvironments termed CardioClusters.
[Nature Communications]
Monsanto, M. M., Wang, B. J., Ehrenberg, Z. R., Echeagaray, O., White, K. S., Alvarez, R., Fisher, K., Sengphanith, S., Muliono, A., Gude, N. A., & Sussman, M. A. (2020). Enhancing myocardial repair with CardioClusters. Nature Communications, 11(1), 3955. https://doi.org/10.1038/s41467-020-17742-z Cite
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Cellular, Mitochondrial and Molecular Alterations Associate with Early Left Ventricular Diastolic Dysfunction in a Porcine Model of Diabetic Metabolic Derangement

Investigators employed a translationally relevant large animal model with Diabetic Metabolic Derangement, having similar anatomic, physiologic and metabolic characteristics of the cardiovascular system with the human situation.
[Scientific Reports]
Heinonen, I., Sorop, O., van Dalen, B. M., Wüst, R. C. I., van de Wouw, J., de Beer, V. J., Octavia, Y., van Duin, R. W. B., Hoogstrate, Y., Blonden, L., Alkio, M., Anttila, K., Stubbs, A., van der Velden, J., Merkus, D., & Duncker, D. J. (2020). Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement. Scientific Reports, 10(1), 13173. https://doi.org/10.1038/s41598-020-68637-4 Cite
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Intercellular Communication Controls Agonist-Induced Calcium Oscillations Independently of Gap Junctions in Smooth Muscle Cells

Investigators report the existence of a communication system among human smooth muscle cells that used mechanical forces to frequency modulate long-range calcium waves.
[Science Advances]
Stasiak, S. E., Jamieson, R. R., Bouffard, J., Cram, E. J., & Parameswaran, H. (2020). Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells. Science Advances, 6(32), eaba1149. https://doi.org/10.1126/sciadv.aba1149 Cite
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Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes

Researchers investigated the metabolic landscape of Danon disease by applying a multi-omics approach and combined structural and functional readouts provided by Raman and atomic force microscopy.
[Journal of Clinical Medicine]
Del Favero, G., Bonifacio, A., Rowland, T. J., Gao, S., Song, K., Sergo, V., Adler, E. D., Mestroni, L., Sbaizero, O., & Taylor, M. R. G. (2020). Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes. Journal of Clinical Medicine, 9(8), 2457. https://doi.org/10.3390/jcm9082457 Cite
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Clinical Trial in a Dish Using iPSCs Shows Lovastatin Improves Endothelial Dysfunction and Cellular Cross-Talk in LMNA Cardiomyopathy

Investigators studied a family affected by dilated cardiomyopathy (DCM) due to a frameshift variant in LMNA. Human induced pluripotent stem cell (iPSC)–derived endothelial cells were generated from patients with LMNA-related DCM and phenotypically characterized.
[Science Translational Medicine]
Sayed, N., Liu, C., Ameen, M., Himmati, F., Zhang, J. Z., Khanamiri, S., Moonen, J.-R., Wnorowski, A., Cheng, L., Rhee, J.-W., Gaddam, S., Wang, K. C., Sallam, K., Boyd, J. H., Woo, Y. J., Rabinovitch, M., & Wu, J. C. (2020). Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy. Science Translational Medicine, 12(554). https://doi.org/10.1126/scitranslmed.aax9276 Cite
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Lactate Activation of α-Cell KATP Channels Inhibits Glucagon Secretion by Hyperpolarizing the Membrane Potential and Reducing Ca2+ Entry

Mouse and human islets were used in combination with confocal microscopy, electrophysiology, GCG immunoassays, and fluorescent thallium flux assays to assess α-cell Ca2+ handling, Vm, KATP currents, and GCG secretion.
[Molecular Metabolism]
Zaborska, K. E., Dadi, P. K., Dickerson, M. T., Nakhe, A. Y., Thorson, A. S., Schaub, C. M., Graff, S. M., Stanley, J. E., Kondapavuluru, R. S., Denton, J. S., & Jacobson, D. A. (2020). Lactate activation of α-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry. Molecular Metabolism, 101056. https://doi.org/10.1016/j.molmet.2020.101056 Cite
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Human Pluripotent Stem Cell-Derived Cardiomyocytes as a Target Platform for Paracrine Protection by Cardiac Mesenchymal Stromal Cells

Investigators tested the impact of paracrine signals on human cardiomyocytes, using human pluripotent stem cell-derived cardiomyocytes as the target of mouse and human cardiac mesenchymal stromal cells with progenitor-like features.
[Scientific Reports]
Constantinou, C., Miranda, A. M. A., Chaves, P., Bellahcene, M., Massaia, A., Cheng, K., Samari, S., Rothery, S. M., Chandler, A. M., Schwarz, R. P., Harding, S. E., Punjabi, P., Schneider, M. D., & Noseda, M. (2020). Human pluripotent stem cell-derived cardiomyocytes as a target platform for paracrine protection by cardiac mesenchymal stromal cells. Scientific Reports, 10(1), 13016. https://doi.org/10.1038/s41598-020-69495-w Cite
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Human Pluripotent Stem Cell-Derived Cardiomyocytes as a Target Platform for Paracrine Protection by Cardiac Mesenchymal Stromal Cells

Investigators tested the impact of paracrine signals on human cardiomyocytes, using human pluripotent stem cell-derived cardiomyocytes as the target of mouse and human cardiac mesenchymal stromal cells with progenitor-like features.
[Scientific Reports]
Constantinou, C., Miranda, A. M. A., Chaves, P., Bellahcene, M., Massaia, A., Cheng, K., Samari, S., Rothery, S. M., Chandler, A. M., Schwarz, R. P., Harding, S. E., Punjabi, P., Schneider, M. D., & Noseda, M. (2020). Human pluripotent stem cell-derived cardiomyocytes as a target platform for paracrine protection by cardiac mesenchymal stromal cells. Scientific Reports, 10(1), 13016. https://doi.org/10.1038/s41598-020-69495-w Cite
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