induced pluripotent stem cells

[Cell Reports] Using patient-derived human induced pluripotent stem cell-forebrain cerebral organoids (hCOs), researchers identified both neural stem cell proliferation and neuronal maturation abnormalities in neurofibromatosis type 1-total gene deletion hCOs.

[Platelets] Investigators found that the plant hormone abscisic acid could increase the generation of megakaryocytes and platelets from human iPSCs.

[Cell Communication and Signaling] JMJD3 has been found to enhance self-renewal ability and reduce the differentiation capacity of ESCs and multipotent stem cells. The authors discuss the recent advances of JMJD3 function in stem cell fate.

[The University of Sydney] Researchers from the University of Sydney have been awarded $6.3 million for three projects which will address stem cell derived-retinal organoids for blindness in adults, iPSC derived cardiomyocytes for chronic heart failure, and help to improve decisions about access to stem cell interventions.

[Nature Protocols] Investigators described a protocol for generating mouse–human chimeric embryos by injecting naive human PSCs converted from the primed state.

[Stem Cell Reviews and Reports] The authors outline the current progress towards fully PSC-derived in vitro co-culture models of the human neuromuscular junction and discuss future directions and challenges that must be overcome in order to create reproducible fully PSC-derived models that can be used for developmental studies, disease modeling, and drug testing.