Patient-Derived iPSC-Cerebral Organoid Modeling of the 17q11.2 Microdeletion Syndrome Establishes CRLF3 as a Critical Regulator of Neurogenesis

By
Justin.choi
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Using patient-derived human induced pluripotent stem cell-forebrain cerebral organoids (hCOs), researchers identified both neural stem cell proliferation and neuronal maturation abnormalities in neurofibromatosis type 1-total gene deletion hCOs.
[Cell Reports]
Wegscheid, M. L., Anastasaki, C., Hartigan, K. A., Cobb, O. M., Papke, J. B., Traber, J. N., Morris, S. M., & Gutmann, D. H. (2021). Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis. Cell Reports, 36(1). https://doi.org/10.1016/j.celrep.2021.109315 Cite
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