Exosome-Transmitted miRNA-335-5p Promotes Colorectal Cancer Invasion and Metastasis by Facilitating Epithelial-Mesenchymal Transition via Targeting RASA1

The authors found that exosomes derived from metastatic colorectal cancer (CRC) cell line SW620 promoted migration, invasion, and epithelial-mesenchymal transition of CRC cells.
[Molecular Therapy-Nucleic Acids]
Sun, X., Lin, F., Sun, W., Zhu, W., Fang, D., Luo, L., Li, S., Zhang, W., & Jiang, L. (2021). Exosome-transmitted miRNA-335-5p promotes colorectal cancer invasion and metastasis by facilitating epithelial-mesenchymal transition via targeting RASA1. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.02.022 Cite
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Dynamic Regulation of Expression of KRAS and Its Effectors Determines the Ability to Initiate Tumorigenesis in Pancreatic Acinar Cells

The authors revealed that control of the expression of KRAS and its effectors regulated the sensitivity of acinar cells to transformation by oncogenic Kras mutations.
[Cancer Research]
Assi, M., Achouri, Y., Loriot, A., Dauguet, N., Dahou, H., Baldan, J., Libert, M., Fain, J. S., Guerra, C., Bouwens, L., Barbacid, M., Lemaigre, F. P., & Jacquemin, P. (2021). Dynamic regulation of expression of KRAS and its effectors determines the ability to initiate tumorigenesis in pancreatic acinar cells. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2976 Cite
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Autophagy Inhibitors Increase the Susceptibility of KRAS-Mutant Human Colorectal Cancer Cells to a Combined Treatment of 2-deoxy-D-glucose and Lovastatin

A combination of lovastatin and 2-deoxy-D-glucose synergistically reduced cell viability, arrested cells in the G2/M phase, and induced apoptosis. The combined treatment also reduced cellular oxygen consumption and extracellular acidification rate, resulting in decreased production of ATP and lower steady-state ATP levels.
[Acta Pharmacologica Sinica]
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Rab5 and Rab11 Maintain Hematopoietic Homeostasis by Restricting Multiple Signaling Pathways in Drosophila

The authors selected three endosome markers, Rab5, Rab7 and Rab11, that play a key role in membrane trafficking and determined whether they participate in hematopoiesis.
[eLife]
Yu, S., Luo, F., & Jin, L. H. (2021). Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila. ELife, 10, e60870. https://doi.org/10.7554/eLife.60870 Cite
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Microvesicles Mediate Sorafenib Resistance in Liver Cancer Cells through Attenuating p53 and Enhancing FOXM1 Expression

Investigators report the effects of liver cancer cell-secreted microvesicles on sorafenib resistance in liver cancer cells HepG2 and Huh7 both in vitro and in vivo.
[Life Sciences]
Jaffar Ali, D., He, C., Xu, H., Kumaravel, S., Sun, B., Zhou, Y., Liu, R., & Xiao, Z. (2021). Microvesicles mediate sorafenib resistance in liver cancer cells through attenuating p53 and enhancing FOXM1 expression. Life Sciences, 271, 119149. https://doi.org/10.1016/j.lfs.2021.119149 Cite
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Using Antisense Oligonucleotides for the Physiological Modulation of the Alternative Splicing of NF1 Exon 23a during PC12 Neuronal Differentiation

Investigators designed antisense Phosphorodiamidate Morpholino Oligomers to modulate exon 23a alternative splicing at physiological conditions of gene expression and tested their impact during PC12 cell line neuronal differentiation.
[Scientific Reports]
Biayna, J., Mazuelas, H., Gel, B., Terribas, E., Dumbovic, G., Rosas, I., Fernández-Rodriguez, J., Blanco, I., Castellanos, E., Carrió, M., Lazaro, C., & Serra, E. (2021). Using antisense oligonucleotides for the physiological modulation of the alternative splicing of NF1 exon 23a during PC12 neuronal differentiation. Scientific Reports, 11(1), 3661. https://doi.org/10.1038/s41598-021-83152-w Cite
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RHO GTPases: From New Partners to Complex Immune Syndromes

Scientists describe the recent discovery of atypical modulators and partners of RHO GTPases, which bring an additional layer of regulation and plasticity to the control of RHO GTPase activities in the immune system.
[Nature Reviews Immunology]
El Masri, R., & Delon, J. (2021). RHO GTPases: from new partners to complex immune syndromes. Nature Reviews Immunology, 1–15. https://doi.org/10.1038/s41577-021-00500-7 Cite
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Whole-Genome Characterization of Lung Adenocarcinomas Lacking the RTK/RAS/RAF Pathway

Investigators used whole-genome sequencing of 85 cases found to be RTK/RAS/RAF pathway alteration(−) by previous studies from The Cancer Genome Atlas to characterize the minority of lung adenocarcinomas lacking apparent alterations in this pathway.
[Cell Reports]
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G3BP1 Promotes Human Breast Cancer Cell Proliferation through Coordinating with GSK-3β and Stabilizing β-Catenin

The authors report that Ras-GTPase activating SH3 domain-binding protein 1 (G3BP1) was upregulated and correlated with poor prognosis in breast cancer.
[Acta Pharmacologica Sinica]
Zhang, C., Liu, H., Zhao, W., Zhao, W., Zhou, H., & Shao, R. (2021). G3BP1 promotes human breast cancer cell proliferation through coordinating with GSK-3β and stabilizing β-catenin. Acta Pharmacologica Sinica, 1–13. https://doi.org/10.1038/s41401-020-00598-w Cite
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Premalignant Oligodendrocyte Precursor Cells Stall in a Heterogeneous State of Replication Stress Prior to Gliomagenesis

Scientists isolated labeled mutant oligodendrocyte precursor cells by laser-capture microdissection and determined gene expression changes by bulk RNA sequencing and a fluctuation analysis called stochastic profiling, which used RNA-sequencing measurements from random pools of ten mutant cells.
[Cancer Research]
Sutcliffe, M. D., Galvao, R. P., Wang, L., Kim, J., Rosenfeld, L. K., Singh, S., Zong, H., & Janes, K. A. (2021). Premalignant oligodendrocyte precursor cells stall in a heterogeneous state of replication stress prior to gliomagenesis. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-1037 Cite
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Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System

The authors investigated the expression of components of the renin-angiotensin system by CSC subpopulations in metastatic head and neck cutaneous squamous cell carcinoma.
[Cells]
Siljee, S., Buchanan, O., Brasch, H. D., Bockett, N., Patel, J., Paterson, E., Purdie, G. L., Davis, P. F., Itinteang, T., & Tan, S. T. (2021). Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System. Cells, 10(2), 243. https://doi.org/10.3390/cells10020243 Cite
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