RAS Induced Senescence of Skin Keratinocytes Is Mediated through Rho-Associated Protein Kinase (ROCK)

Researchers reported that the Rho-associated protein kinase (ROCK) signaling pathway was a critical regulator of oncogene-induced senescence in skin carcinogenesis.
[Molecular Carcinogenesis]
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Tetraspanin 6 Is a Regulator of Carcinogenesis in Colorectal Cancer

Using a combination of in vitro and in vivo assays, scientists demonstrate that Tspan6 functioned as a tumor suppressor in colorectal cancer by attenuating the epidermal growth factor receptor–based signaling axis.
[Proceedings of the National Academy of Sciences of the United States of America]
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Inhibiting BCKDK in Triple Negative Breast Cancer Suppresses Protein Translation, Impairs Mitochondrial Function, and Potentiates Doxorubicin Cytotoxicity

TNBC cells treated with doxorubicin exhibited reduced branched-chain ketoacid dehydrogenase kinase (BCKDK) expression and intracellular branched-chain ketoacids (BCKAs). Genetic and pharmacological inhibition of BCKDK in TNBC cell lines also showed a similar reduction in intracellular and secreted BCKAs.
[Cell Death Discovery]
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RAS Specific Protease Induces Irreversible Growth Arrest via p27 in Several KRAS Mutant Colorectal Cancer Cell Lines

Researchers demonstrated, using isogenic mouse fibroblasts expressing a single isoform of RAS or mutant KRAS, that RAS/RAP1-specific endopeptidase equally inactivated all isoforms of RAS as well as the major oncogenic KRAS mutants.
[Scientific Reports]
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Sulfarotene, a Synthetic Retinoid, Overcomes Stemness and Sorafenib Resistance of Hepatocellular Carcinoma via Suppressing SOS2-RAS Pathway

Researchers evaluated the pharmacology and mechanism of sulfarotene, a new type of synthetic retinoid, on the cancer stem cell-like properties of hepatocellular carcinoma (HCC) tumor-repopulating cells, and assessed its preclinical efficacy in models of HCC patient-derived xenografts
[Journal of Experimental & Clinical Cancer Research]
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Colon Adenocarcinoma-Derived Cells Possessing Stem Cell Function Can Be Modulated Using Renin-Angiotensin System Inhibitors

Primary cell lines derived from four high-grade colon adenocarcinoma tissues were treated with renin-angiotensin system inhibitors to investigate their effect on cellular metabolism, tumorsphere formation and transcription of pluripotency genes.
[PLoS One]
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The Chemokine CCL1 Triggers an AMFR-SPRY1 Pathway That Promotes Differentiation of Lung Fibroblasts into Myofibroblasts and Drives Pulmonary Fibrosis

Scientists examined the role of CCL1 in pulmonary fibrosis (PF). Bronchoalveolar lavage fluid from PF mouse models contained high amounts of CCL1, as did lung biopsies from PF patients.
[Immunity]
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Context-Dependent Immunomodulatory Effects of MEK Inhibition are Enhanced with T-Cell Agonist Therapy

Scientists modeled tumor-specific MEK inhibition (MEKi) through CRISPR/Cas-mediated genome editing of tumor cells and pharmacologic MEKi with cobimetinib in a RAS-driven model of colorectal cancer.
[Cancer Immunology Research]
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Vitamin D Suppresses Bleomycin-Induced Pulmonary Fibrosis by Targeting the Local Renin–Angiotensin System in the Lung

The authors demonstrated that in lung fibroblast cultures, TGF-β and angiotensin II synergistically induced TGF-β, AT1R, α-SMA, collagen type I and fibronectin, whereas 1,25-dihydroxyvitamin D markedly suppressed the induction of these fibrotic markers.
[Scientific Reports]
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Telocytes Promote Hepatocellular Carcinoma by Activating the ERK Signaling Pathway and miR-942-3p/MMP9 Axis

Primary telocytes (TCs) from liver para-cancer tissues were cultured in vitro. To verify the role of TCs in hepatocellular carcinoma, a metastatic cancer animal model was established using three types of liver cancer cell lines in vivo.
[Cell Death Discovery]
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NDRG1 Enhances the Sensitivity of Cetuximab by Modulating EGFR Trafficking in Colorectal Cancer

Researchers found that NDRG1 enhanced the sensitivity of cetuximab in colorectal cancer cell lines by inhibiting the expression of epidermal growth factor receptor (EGFR); blocking EGFR phosphorylation and reducing the EGFR distribution in the cell membrane, cytoplasm and nucleus.
[Oncogene]
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