Saccharomyces boulardii Modulates Oxidative Stress and Renin Angiotensin System Attenuating Diabetes-Induced Liver Injury in Mice

Scientists investigated through histopathological and biochemical analyses, the effects of eight weeks of administration of Saccharomyces boulardii yeast on the liver of streptozotocin induced diabetic C57BL/6 mice.
[Scientific Reports]
Barssotti, L., Abreu, I. C. M. E., Brandão, A. B. P., Albuquerque, R. C. M. F., Ferreira, F. G., Salgado, M. A. C., Dias, D. D. S., De Angelis, K., Yokota, R., Casarini, D. E., Souza, L. B., Taddei, C. R., & Cunha, T. S. (2021). Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice. Scientific Reports, 11(1), 9189. https://doi.org/10.1038/s41598-021-88497-w Cite
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Early Response in Phosphorylation of Ribosomal Protein S6 Is Associated with Sensitivity to Trametinib in Colorectal Cancer Cells

The authors investigated the value of the response in pS6 for predicting the efficacy of trametinib, a MEK inhibitor, in patients with RAS/BRAF mutant colorectal cancer (CRC) using patient-derived CRC organoids.
[Laboratory Investigation]
Hirashita, Y., Tsukamoto, Y., Kudo, Y., Kakisako, D., Kurogi, S., Hijiya, N., Nakada, C., Uchida, T., Hirashita, T., Hiratsuka, T., Akagi, T., Ueda, Y., Shiroshita, H., Etoh, T., Mizukami, K., Honda, K., Okimoto, T., Kodama, M., Inomata, M., … Murakami, K. (2021). Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells. Laboratory Investigation, 1–12. https://doi.org/10.1038/s41374-021-00590-w Cite
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EPHA2-Dependent Outcompetition of KRASG12D Mutant Cells by Wild-Type Neighbors in the Adult Pancreas

Researchers investigated how the adult pancreas maintains tissue health in vivo following sporadic expression of oncogenic Kras (KrasG12D), the key driver mutation in human pancreatic cancer.
[Current Biology]
Hill, W., Zaragkoulias, A., Salvador-Barbero, B., Parfitt, G. J., Alatsatianos, M., Padilha, A., Porazinski, S., Woolley, T. E., Morton, J. P., Sansom, O. J., & Hogan, C. (2021). EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas. Current Biology, 0(0). https://doi.org/10.1016/j.cub.2021.03.094 Cite
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The Transcription Factor Slug Uncouples Pancreatic Cancer Progression from the Raf-Mek1/2-Erk1/2 Pathway

Scientists generated pancreatic cancer cells resistant to Mek1/2 inhibition, which were also resistant to KRAS and Erk1/2 inhibitors.
[Cancer Research]
Bilal, F., Arenas, E. J., Pedersen, K., Martínez-Sabadell, A., Nabet, B., Guruceaga, E., Vicent, S., Tabernero, J., Maraculla, T., & Arribas, J. (2021). The transcription factor Slug uncouples pancreatic cancer progression from the Raf-Mek1/2-Erk1/2 pathway. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-4263 Cite
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A Novel Cystathionine γ-Lyase Inhibitor, I194496, Inhibits the Growth and Metastasis of Human TNBC via Downregulating Multiple Signaling Pathways

Scientists investigated the activity of the novel cystathionine γ-lyase inhibitor I194496 against TNBC in vivo and in vitro. The anticancer activity of I194496 in vitro were detected by MTS, EdU, and transwell assays.
[Scientific Reports]
Liu, Y., Wang, L., Zhang, X., Deng, Y., Pan, L., Li, H., Shi, X., & Wang, T. (2021). A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways. Scientific Reports, 11(1), 8963. https://doi.org/10.1038/s41598-021-88355-9 Cite
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Minor Intron Retention Drives Clonal Hematopoietic Disorders and Diverse Cancer Predisposition

The authors identified that impaired minor intron excision via ZRSR2 loss enhanced hematopoietic stem cell self-renewal.
[Nature Genetics]
Inoue, D., Polaski, J. T., Taylor, J., Castel, P., Chen, S., Kobayashi, S., Hogg, S. J., Hayashi, Y., Pineda, J. M. B., El Marabti, E., Erickson, C., Knorr, K., Fukumoto, M., Yamazaki, H., Tanaka, A., Fukui, C., Lu, S. X., Durham, B. H., Liu, B., … Abdel-Wahab, O. (2021). Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nature Genetics, 1–12. https://doi.org/10.1038/s41588-021-00828-9 Cite
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C3G Downregulation Induces the Acquisition of a Mesenchymal Phenotype That Enhances Aggressiveness of Glioblastoma Cells

The authors report that C3G downregulation promoted the acquisition of a more mesenchymal phenotype that enhanced the migratory and invasive capacity of glioblastoma cells.
[Cell Death & Disease]
Manzano, S., Gutierrez-Uzquiza, A., Bragado, P., Sequera, C., Herranz, Ó., Rodrigo-Faus, M., Jauregui, P., Morgner, S., Rubio, I., Guerrero, C., & Porras, A. (2021). C3G downregulation induces the acquisition of a mesenchymal phenotype that enhances aggressiveness of glioblastoma cells. Cell Death & Disease, 12(4), 1–17. https://doi.org/10.1038/s41419-021-03631-w Cite
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The Human Intermediate Prolactin Receptor Is a Mammary Proto-Oncogene

An analogous truncated mouse prolactin receptor (mPRLr) was found to be oncogenic when co-expressed with wild-type mPRLr. The authors determined if a similar transforming event occurs with the hPRLr in human breast epithelial cells.
[npj Breast Cancer]
Grible, J. M., Zot, P., Olex, A. L., Hedrick, S. E., Harrell, J. C., Woock, A. E., Idowu, M. O., & Clevenger, C. V. (2021). The human intermediate prolactin receptor is a mammary proto-oncogene. Npj Breast Cancer, 7(1), 1–11. https://doi.org/10.1038/s41523-021-00243-7 Cite
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Clinical Significance of RAS Pathway Alterations in Pediatric Acute Myeloid Leukemia

Scientists analyzed the frequency, clinical significance, and prognostic relevance of RAS pathway alterations in 328 pediatric patients with de novo acute myeloid leukemia.
[Haematologica]
Kaburagi, T., Yamato, G., Shiba, N., Yoshida, K., Hara, Y., Tabuchi, K., Shiraishi, Y., Ohki, K., Sotomatsu, M., Arakawa, H., Matsuo, H., Shimada, A., Taki, T., Kiyokawa, N., Tomizawa, D., Horibe, K., Miyano, S., Taga, T., Adachi, S., … Hayashi, Y. (2020). Clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia. Haematologica. https://doi.org/10.3324/haematol.2020.269431 Cite
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Cooperation between Oncogenic Ras and Wild-Type p53 Stimulates STAT Non-cell Autonomously to Promote Tumor Radioresistance

Investigators discovered that cellular response to genotoxic stress cooperated with oncogenic Ras to activate JAK/STAT non-cell autonomously in the tumor microenvironment.
[Communications Biology]
Dong, Y.-L., Vadla, G. P., Lu, J.-Y. (Jim), Ahmad, V., Klein, T. J., Liu, L.-F., Glazer, P. M., Xu, T., & Chabu, C.-Y. (2021). Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-021-01898-5 Cite
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FGFR2 Fusion Proteins Drive Oncogenic Transformation of Mouse Liver Organoids towards Cholangiocarcinoma

Tumor organoids and 2D cell lines derived from CCA lesions were addicted to FF signaling via Ras-Erk, regardless of FF identity or V565F mutation.
[Journal of Hepatology]
Cristinziano, G., Porru, M., Lamberti, D., Buglioni, S., Rollo, F., Amoreo, C. A., Manni, I., Giannarelli, D., Cristofoletti, C., Russo, G., Borad, M. J., Grazi, G. L., Diodoro, M. G., Giordano, S., Sacconi, A., Forcato, M., Anastasi, S., Leonetti, C., & Segatto, O. (2021). FGFR2 fusion proteins drive oncogenic transformation of mouse liver organoids towards cholangiocarcinoma. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2021.02.032 Cite
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