Researchers reported that the Rho-associated protein kinase (ROCK) signaling pathway was a critical regulator of oncogene-induced senescence in skin carcinogenesis.
[zotpress userid=” items=’EZN3SDA2′ style=’apa’ cite=’yes’]
Using a combination of in vitro and in vivo assays, scientists demonstrate that Tspan6 functioned as a tumor suppressor in colorectal cancer by attenuating the epidermal growth factor receptor–based signaling axis.
[Proceedings of the National Academy of Sciences of the United States of America]
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TNBC cells treated with doxorubicin exhibited reduced branched-chain ketoacid dehydrogenase kinase (BCKDK) expression and intracellular branched-chain ketoacids (BCKAs). Genetic and pharmacological inhibition of BCKDK in TNBC cell lines also showed a similar reduction in intracellular and secreted BCKAs.
[Cell Death Discovery]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Researchers demonstrated, using isogenic mouse fibroblasts expressing a single isoform of RAS or mutant KRAS, that RAS/RAP1-specific endopeptidase equally inactivated all isoforms of RAS as well as the major oncogenic KRAS mutants.
[zotpress userid=” items=’HVAZTTTC’ style=’apa’ cite=’yes’]
Researchers evaluated the pharmacology and mechanism of sulfarotene, a new type of synthetic retinoid, on the cancer stem cell-like properties of hepatocellular carcinoma (HCC) tumor-repopulating cells, and assessed its preclinical efficacy in models of HCC patient-derived xenografts
[Journal of Experimental & Clinical Cancer Research]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Primary cell lines derived from four high-grade colon adenocarcinoma tissues were treated with renin-angiotensin system inhibitors to investigate their effect on cellular metabolism, tumorsphere formation and transcription of pluripotency genes.
[zotpress userid=” items=’MZT953QE’ style=’apa’ cite=’yes’]
Scientists examined the role of CCL1 in pulmonary fibrosis (PF). Bronchoalveolar lavage fluid from PF mouse models contained high amounts of CCL1, as did lung biopsies from PF patients.
[zotpress userid=” items=’AKGBND5J’ style=’apa’ cite=’yes’]
Scientists modeled tumor-specific MEK inhibition (MEKi) through CRISPR/Cas-mediated genome editing of tumor cells and pharmacologic MEKi with cobimetinib in a RAS-driven model of colorectal cancer.
[Cancer Immunology Research]
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The authors demonstrated that in lung fibroblast cultures, TGF-β and angiotensin II synergistically induced TGF-β, AT1R, α-SMA, collagen type I and fibronectin, whereas 1,25-dihydroxyvitamin D markedly suppressed the induction of these fibrotic markers.
[zotpress userid=” items=’H3ZAB5DU’ style=’apa’ cite=’yes’]
Primary telocytes (TCs) from liver para-cancer tissues were cultured in vitro. To verify the role of TCs in hepatocellular carcinoma, a metastatic cancer animal model was established using three types of liver cancer cell lines in vivo.
[Cell Death Discovery]
[zotpress userid=” items=’REHJQWM7′ style=’apa’ cite=’yes’]
Researchers found that NDRG1 enhanced the sensitivity of cetuximab in colorectal cancer cell lines by inhibiting the expression of epidermal growth factor receptor (EGFR); blocking EGFR phosphorylation and reducing the EGFR distribution in the cell membrane, cytoplasm and nucleus.
[zotpress userid=’7992332′ items=’KAHZBJXQ’ style=’apa’ cite=’yes’]