Tumor-Associated Neutrophils Secrete AGR2 to Promote Colorectal Cancer Metastasis via Its Receptor CD98hc–xCT

Scientists investigated the cellular source for secreted anterior gradient-2 (AGR2) in the tumor microenvironment and underlying mechanisms mediating secreted AGR2’s effects.
[Gut]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

De Novo Expression of Gastrokines in Pancreatic Precursor Lesions Impede the Development of Pancreatic Cancer

Scientists performed the molecular and histological assessment of patient-derived PanINs, tumor tissues and pancreas from mouse models with PDAC, where they noted marked upregulation of gastrokine proteins.
[Oncogene]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Angiogenesis Depends upon EPHB4-Mediated Export of Collagen IV from Vascular Endothelial Cells

The authors showed that induced endothelial cell (EC)-specific disruption of Ephb4 in mice resulted in accumulation of collagen IV in the EC endoplasmic reticulum leading to EC apoptotic death and defective developmental, neonatal and pathological angiogenesis.
[JCI Insight]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
AbstractFull Article
Bookmark

No account yet? Register

Share

Inhibition of Rac1 Attenuates Radiation-Induced Lung Injury While Suppresses Lung Tumor in Mice

By establishing a mouse model of radiation-induced lung injury and orthotopic lung tumor-bearing mouse model, investigators detected the role of Rac1 inhibition in the protection of RILI and suppression of lung tumor.
[Cell Death Discovery]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

NLK Is Required for Ras/ERK/SRF/ELK Signaling to Tune Skeletal Muscle Development by Phosphorylating SRF and Antagonizing the SRF/MKL Pathway

Researchers showed that Nemo-like kinase (NLK) was required for the promotion of SRF/ELK signaling in human and mouse cells.
[Cell Death Discovery]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Circ_0007385 Regulates Cell Proliferation, Apoptosis and Stemness via Targeting miR-493-3p/RAB22A Axis in Non-Small Cell Lung Cancer

Expression levels of circ_0007385, microRNA-493-3p (miR-493-3p) and Ras-related protein Rab-22A (RAB22A) were detected by quantitative real-time polymerase chain reaction (qRT-PCR) in NSCLC tissues and cells.
[Thoracic Cancer]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

EGPI-1, a Novel eIF4E/eIF4G Interaction Inhibitor, Inhibits Lung Cancer Cell Growth and Angiogenesis through Ras/MNK/ERK/eIF4E Signaling Pathway

Scientists synthesized a series of small molecule compounds with the potential to inhibit eIF4E. Among them, the compound EGPI-1 significantly inhibited the proliferation of a variety of lung cancer cells such as A549, NCI-H460, NCI-H1650 and 95D without inhibiting the proliferation of HUVEC cells.
[Chemico-Biological interactions]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Combinatorial Effects of Azacitidine and Trametinib on NRAS-Mutated Melanoma

Exposure to trametinib and azacitidine prevented development of trametinib resistance in NRAS-mutated human melanoma cells in vitro. Azacitidine acted synergistically with trametinib to inhibit the growth of trametinib-resistant melanoma cells.
[Pediatric Blood & Cancer]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Oncogenic Dependency on STAT3 Serine Phosphorylation in KRAS Mutant Lung Cancer

Researchers demonstrate that lung adenocarcinoma was suppressed in oncogenic KrasG12D-driven mouse models engineered for pS727-STAT3 deficiency.
[Oncogene]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Ras Inhibitor Farnesylthiosalicylic Acid Conjugated with IR783 Dye Exhibits Improved Tumor-Targeting and Altered Anti-Breast Cancer Mechanisms in Mice

Investigators demonstrated that organic anion transporting polypeptide and endocytosis synergistically drove the uptake of the farnesylthiosalicylic acid-IR783 conjugate in breast cancer MDA-MB-231 cells, resulting in superior tumor-targeting ability of the conjugate both in vitro and in vivo.
[Acta Pharmacologica Sinica]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Concurrent Disruption of Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis

Investigators showed that an unanticipated severe tumor phenotype was contributed collectively by severe cholestasis, metabolic changes, upregulated cell cycle progression and disruption of circadian rhythm in mutant hepatocytes.
[Molecular Cancer Research]
[zotpress userid=’7992332′ items=’EEEEEEEE’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share