3D Tumor Angiogenesis Models: Recent Advances and Challenges

Scientists summarize recent advancements of 3D tumor vascular model systems which include tissue engineering-based tumor models; vascular organoid models, and organ-on-chips and their importance in replicating the tumor angiogenesis along with the associated challenges to design improved models.
[Journal of Cancer Research and Clinical Oncology]
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Current Status of Organoid Culture in Urological Malignancy

The authors summarize the development and applications of three-dimensional organoid cultures in urological cancers, mainly focusing on prostate, urinary bladder and kidney cancers, and assess the future prospects of this model.
[International Journal of Urology]
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Targeting the Complex I and III of Mitochondrial Electron Transport Chain as a Potentially Viable Option in Liver Cancer Management

The authors reported that depletion of mitochondrial DNA, pharmacologic inhibition of mitochondrial electron transport chain (mETC) complex I/complex III, or genetic of mETC complex I restricted cancer cell growth and clonogenicity in various preclinical models of liver cancer.
[Cell Death Discovery]
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Human Kidney Organoids Reveal the Role of Glutathione in Fabry Disease

Researchers modeled Fabry disease using human iPSC-derived kidney organoids and the CRISPR–Cas9 genome-editing system.
[Experimental & Molecular Medicine]
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An Airway Organoid-Based Screen Identifies a Role for the HIF1α-Glycolysis Axis in SARS-CoV-2 Infection

It is urgent to develop disease models to dissect mechanisms regulating SARS-CoV-2 infection. Researchers derived airway organoids from human pluripotent stem cells.
[Cell Reports]
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Tiered Testing of Micro- and Nanoplastics Using Intestinal In Vitro Models to Support Hazard Assessments

Researchers analysed the suitability of in vitro models for assessing the interaction of micro- and nanoplastics with intestinal cells.
[Environment International]
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Plexin-B2 Orchestrates Collective Stem Cell Dynamics via Actomyosin Contractility, Cytoskeletal Tension and Adhesion

Scientists showed a role of guidance receptor Plexin-B2 in organizing actomyosin network and adhesion complexes during multicellular development of human embryonic stem cells and neuroprogenitor cells.
[Nature Communications]
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A Cis-Acting Structural Variation at the ZNF558 Locus Controls a Gene Regulatory Network in Human Brain Development

Scientists identified a KRAB-ZFP transcription factor, ZNF558, that was expressed in human but not chimpanzee forebrain neural progenitor cells.
[Cell Stem Cell]
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Opportunities and Challenges of Glioma Organoids

Researchers review the three methods currently used to establish glioma organoids, and introduced how they play a role in the diagnosis and treatment of glioma.
[Cell Communication and Signaling]
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Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment

Investigators evaluated the difference between controls’ and phosphatase and tensin homolog-induced putative kinase 1 (PINK1) patients’ derived neurons in their transition from neuroepithelial stem cells to neurons, allowing them to identify potential pathways to target with repurposed compounds.
[Movement Disorders]
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A Mix of Functional Amino Acids and Grape Polyphenols Promotes the Growth of Piglets, Modulates the Gut Microbiota In Vivo and Regulates Epithelial Homeostasis in Intestinal Organoids

Experiments in piglet jejunum organoids revealed that the mix of amino acids and polyphenols upregulated the gene expression of epithelial differentiation markers while it reduced the gene expression of proliferation and innate immunity markers.
[Amino Acids]
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