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Progenitor Potential of Lung Epithelial Organoid Cells in a Transplantation Model

[Cell Reports] The authors transplanted organoid cells derived from alveolar type II cells enriched by SCA1-negative status or multipotent SCA1-positive progenitor cells into injured mouse lungs.

Human Pluripotent Stem Cell-Derived Kidney Organoids for Personalized Congenital and Idiopathic Nephrotic Syndrome Modeling

[Development] Next-generation podocytes in kidney organoids enabled personalized idiopathic nephrotic syndrome modeling as shown by activated slit diaphragm signaling and podocyte injury following protamine sulfate, puromycin aminonucleoside treatment and exposure to nephrotic syndrome plasma containing pathogenic permeability factors.

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

[Cancer Research] Investigators showed that the mitochondrial calcium uniporter promoted pancreatic ductal adenocarcinoma cell migration, invasion, metastasis, and metabolic stress resistance by activating the Keap1-Nrf2 antioxidant program.

Mutation in the CCAL1 Locus Accounts for Bidirectional Process of Human Subchondral Bone Turnover and Cartilage Mineralization

[Rheumatology] OPG-XL was studied by human induced pluripotent stem cells expressing OPG-XL and two isogenic CRISPR/Cas9-corrected controls in cartilage and bone organoids.

Generation of Human Embryonic Stem Cell-Derived Lung Organoids

[STAR Protocols] This protocol describes how to generate lung organoids from human embryonic stem cells. Lung organoids form by self-assembly in Matrigel and contain lung epithelial cell types.

Patient-Derived Endometrial Organoids from MRKH Patients: Insight in Disease Causing Pathways

[Disease Models & Mechanisms] Investigators developed long-term expandable organoid cultures from endometrium found in uterine rudiment horns of Mayer-Rokitansky-Küster-Hauser (MRKH) patients.