Fungal Brain Infection Modeled in a Human-Neurovascular-Unit-on-a-Chip with a Functional Blood-Brain Barrier

Scientists showed that the neurotropism of Cryptococcus neoformans and its ability to penetrate the blood-brain barrier (BBB) could be modeled by the co-culture of human neural stem cells, brain microvascular endothelial cells and brain vascular pericytes in a human-neurovascular-unit-on-a-chip maintained by a stepwise gravity-driven unidirectional flow and recapitulating the structural and functional features of the BBB.
[Nature Biomedical Engineering]
Kim, J., Lee, K.-T., Lee, J. S., Shin, J., Cui, B., Yang, K., Choi, Y. S., Choi, N., Lee, S. H., Lee, J.-H., Bahn, Y.-S., & Cho, S.-W. (2021). Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier. Nature Biomedical Engineering, 1–17. https://doi.org/10.1038/s41551-021-00743-8 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Bayer to Advance Two First-of-Its-Kind Investigational Cell and Gene Therapies for Parkinson’s Disease

Bayer AG announced that BlueRock Therapeutics successfully administered the first dose of its investigational pluripotent stem cell-derived dopaminergic neurons, named DA01, to a Parkinson’s disease patient in their open-label Phase I clinical safety and tolerability study.
[Bayer AG (BusinessWire, Inc.)]
Press Release
Bookmark

No account yet? Register

0
Share

Replicative Senescence Dictates the Emergence of Disease-Associated Microglia and Contributes to Aβ Pathology

Researchers aimed to understand the long-term impact of the early and prolonged microglial proliferation observed in Alzheimer’s disease, hypothesizing that extensive and repeated cycling would engender a distinct transcriptional and phenotypic trajectory.
[Cell Reports]
Hu, Y., Fryatt, G. L., Ghorbani, M., Obst, J., Menassa, D. A., Martin-Estebane, M., Muntslag, T. A. O., Olmos-Alonso, A., Guerrero-Carrasco, M., Thomas, D., Cragg, M. S., & Gomez-Nicola, D. (2021). Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology. Cell Reports, 35(10). https://doi.org/10.1016/j.celrep.2021.109228 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Small Molecule 1a Reduces FMRpolyG-Mediated Toxicity in In Vitro and In Vivo Models for FMR1 Premutation

Scientists presented for the first time primary hippocampal neurons derived from the ubiquitous inducible mouse model used as a screening tool for targeted interventions.
[Human Molecular Genetics]
Haify, S. N., Buijsen, R. A. M., Verwegen, L., Severijnen, L.-A. W. F. M., de Boer, H., Boumeester, V., Monshouwer, R., Yang, W. Y., Cameron, M. D., Willemsen, R., Disney, M. D., & Hukema, R. K. (2021). Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation. Human Molecular Genetics, ddab143. https://doi.org/10.1093/hmg/ddab143 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Differentiation of Human Adult-Derived Stem Cells towards a Neural Lineage Involves a Dedifferentiation Event Prior to Differentiation to Neural Phenotypes

Scientists demonstrated that hPDLSCs, hBMSCs and hDPSCs could directly differentiate into neuron-like cells without passing through a mitotic stage and that they shrunk dramatically and changed their morphology to that of neuron-like cells through active neurite extension.
[Scientific Reports]
Bueno, C., Martínez-Morga, M., García-Bernal, D., Moraleda, J. M., & Martínez, S. (2021). Differentiation of human adult-derived stem cells towards a neural lineage involves a dedifferentiation event prior to differentiation to neural phenotypes. Scientific Reports, 11(1), 12034. https://doi.org/10.1038/s41598-021-91566-9 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Isorhapontigenin Ameliorates Cerebral Ischemia/Reperfusion Injury via Modulating Kinase Cε/Nrf2/HO-1 Signaling Pathway

Focal cerebral ischemia-reperfusion injury model and primary cortical neurons were established an oxygen-glucose deprivation injury model. Neuronal cell viability was determined by MTT assay. Western blot analysis was determined for protein expression.
[Brain and Behavior]
Xue, Z., Zhao, K., Sun, Z., Wu, C., Yu, B., Kong, D., & Xu, B. (n.d.). Isorhapontigenin ameliorates cerebral ischemia/reperfusion injury via modulating Kinase Cε/Nrf2/HO-1 signaling pathway. Brain and Behavior, n/a(n/a), e02143. https://doi.org/https://doi.org/10.1002/brb3.2143 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Deletion of lncRNA XACT Does Not Change Expression Dosage of X-linked Genes, but Affects Differentiation Potential in human PSCs

Scientists reported that a common mechanism for the initiation of the erosion of X chromosome inactivation of female human PSCs depended on XIST loss but not XACT accumulation on inactive X chromosomes.
[Cell Reports]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

BlueRock Therapeutics Announces First Patient Dosed with DA01 in Phase I Study in Patients with Advanced Parkinson’s Disease

BlueRock Therapeutics announced the dose administration for the first patient in a Phase I, open-label study of PSC-derived dopaminergic neurons in patients with advanced Parkinson’s disease.
[BlueRock Therapeutics]
Press Release
Bookmark

No account yet? Register

0
Share

Interactions between Cancer Cells and Immune Cells Drive Transitions to Mesenchymal-Like States in Glioblastoma

Scientists dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments.
[Cancer Cell]
Hara, T., Chanoch-Myers, R., Mathewson, N. D., Myskiw, C., Atta, L., Bussema, L., Eichhorn, S. W., Greenwald, A. C., Kinker, G. S., Rodman, C., Castro, L. N. G., Wakimoto, H., Rozenblatt-Rosen, O., Zhuang, X., Fan, J., Hunter, T., Verma, I. M., Wucherpfennig, K. W., Regev, A., … Tirosh, I. (2021). Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2021.05.002 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment

Researchers report on the development of an enhanced synergistic combination therapy comprising polyacetal–curcumin nanoconjugate and neural stem cells derived from induced pluripotent stem cells + mesenchymal stem cells treatment as a treatment option for severe sub-acute traumatic spinal cord injury.
[International Journal of Molecular Sciences]
Full Article
Bookmark

No account yet? Register

0
Share

Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis

Old and young mouse brains, metastatic and naïve, were analyzed by flow cytometry. Immune populations were depleted using antibodies or a colony stimulating factor-1 receptor (CSF-1R) inhibitor, and brain metastasis assays were conducted.
[Clinical Cancer Research]
Wu, A. M. L., Gossa, S., Samala, R., Chung, M. A., Gril, B., Yang, H., Thorsheim, H. R., Tran, A. D., Wei, D., Taner, E., Isanogle, K., Yang, Y., Dolan, E. L., Robinson, C. M., Difilippantonio, S., Lee, M., Khan, I., Smith, Q. R., McGavern, D. B., … Steeg, P. S. (2021). Aging and CNS myeloid cell depletion attenuate breast cancer brain metastasis. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-1549 Cite
Abstract
Bookmark

No account yet? Register

0
Share
Share