Transneuronal Delivery of Hyper-Interleukin-6 Enables Functional Recovery after Severe Spinal Cord Injury in Mice

The authors report significant locomotor recovery of both hindlimbs after a complete spinal cord crush. This was achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hyper-IL-6, a potent designer cytokine stimulating JAK/STAT3 signaling and axon regeneration.
[Nature Communications]
Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice | Nature Communications. (n.d.). Retrieved January 15, 2021, from https://www.nature.com/articles/s41467-020-20112-4 Cite
Full ArticlePress Release
Bookmark

No account yet? Register

0
Share

O-GlcNAcylation Ameliorates the Pathological Manifestations of Alzheimer’s Disease by Inhibiting Necroptosis

The authors found that O-GlcNAcylation plays a protective role in Alzheimer’s disease by inhibiting necroptosis.
[Science Advances]
Park, J., Ha, H.-J., Chung, E. S., Baek, S. H., Cho, Y., Kim, H. K., Han, J., Sul, J. H., Lee, J., Kim, E., Kim, J., Yang, Y. R., Park, M., Kim, S. H., Arumugam, T. V., Jang, H., Seo, S. W., Suh, P.-G., & Jo, D.-G. (2021). O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis. Science Advances, 7(3), eabd3207. https://doi.org/10.1126/sciadv.abd3207 Cite
Full Article
Bookmark

No account yet? Register

0
Share

A Subset of Spinal Dorsal Horn Interneurons Crucial for Gating Touch-Evoked Pain-Like Behavior

Scientists dentified a subset of inhibitory interneurons in the spinal dorsal horn (SDH) operated by adeno-associated viral vectors incorporating a neuropeptide Y promoter (AAV-NpyP+) and showed that specific ablation or silencing of AAV-NpyP+ SDH interneurons converted touch-sensing Aβ fiber-derived signals to morphine-resistant pain-like behavioral responses.
[Proceedings of the National Academy of Sciences of the United States of America]
Tashima, R., Koga, K., Yoshikawa, Y., Sekine, M., Watanabe, M., Tozaki-Saitoh, H., Furue, H., Yasaka, T., & Tsuda, M. (2021). A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2021220118 Cite
Abstract
Bookmark

No account yet? Register

0
Share

BlueRock Therapeutics in Collaboration with Memorial Sloan Kettering Cancer Center Receives IND Clearance for DA01 in Parkinson’s Disease

BlueRock Therapeutics, in collaboration with Memorial Sloan Kettering Cancer Center, announced that the US FDA has cleared their Investigational New Drug application to proceed with a Phase I study in patients with advanced Parkinson’s disease (PD). This is the first trial in the US to study pluripotent stem cell-derived dopaminergic neurons in patients with Parkinson’s disease.
[BlueRock Therapeutics (PR Newswire, Inc.)]
Press Release
Bookmark

No account yet? Register

0
Share

Glioma Stem Cells and Their Roles within the Hypoxic Tumor Microenvironment

Investigators summarize the impact of hypoxia and acidic stress on glioma stem cell signaling and biologic phenotypes, and potential methods to inhibit these pathways.
[Theranostics]
Boyd, N. H., Tran, A. N., Bernstock, J. D., Etminan, T., Jones, A. B., Gillespie, G. Y., Friedman, G. K., & Hjelmeland, A. B. (2021). Glioma stem cells and their roles within the hypoxic tumor microenvironment. Theranostics, 11(2), 665–683. https://doi.org/10.7150/thno.41692 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Targeting of Glioma Stem-Like Cells with a Parthenolide Derivative ACT001 through Inhibition of AEBP1/PI3K/AKT Signaling

The effects of ACT001 on cell survival of normal human astrocytes and patient-derived glioma stem-like cells were evaluated. RNA-Seq were performed to detect differentially expressed genes.
[Theranostics]
Hou, Y., Sun, B., Liu, W., Yu, B., Shi, Q., Luo, F., Bai, Y., & Feng, H. (2021). Targeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling. Theranostics, 11(2), 555–566. https://doi.org/10.7150/thno.49250 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Altered Hippocampal Gene Expression, Glial Cell Population, and Neuronal Excitability in Aminopeptidase P1 Deficiency

The authors showed that a deficiency of aminopeptidase P1 modified the glial population and neuronal excitability in the hippocampus.
[Scientific Reports]
Yoon, S. H., Bae, Y.-S., Oh, S. P., Song, W. S., Chang, H., & Kim, M.-H. (2021). Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency. Scientific Reports, 11(1), 932. https://doi.org/10.1038/s41598-020-79656-6 Cite
Full Article
Bookmark

No account yet? Register

0
Share

STING Controls Nociception via Type I Interferon Signaling in Sensory Neurons

Investigators demonstrated that STING was a critical regulator of nociception through type-I interferon signaling in peripheral nociceptive sensory neurons.
[Nature]
Donnelly, C. R., Jiang, C., Andriessen, A. S., Wang, K., Wang, Z., Ding, H., Zhao, J., Luo, X., Lee, M. S., Lei, Y. L., Maixner, W., Ko, M.-C., & Ji, R.-R. (2021). STING controls nociception via type I interferon signalling in sensory neurons. Nature, 1–6. https://doi.org/10.1038/s41586-020-03151-1 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Multiple Signaling Pathways Are Essential for Synapse Formation Induced by Synaptic Adhesion Molecules

To explore what signaling pathways may be involved, investigators employed heterologous synapse formation assays in which a synaptic adhesion molecule expressed in a nonneuronal cell induced pre- or postsynaptic specializations in cocultured neurons.
[Proceedings of the National Academy of Sciences of the United States of America]
Jiang, X., Sando, R., & Südhof, T. C. (2021). Multiple signaling pathways are essential for synapse formation induced by synaptic adhesion molecules. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2000173118 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Neuroinvasion of SARS-CoV-2 in Human and Mouse Brain

Scientists used three independent approaches to probe the capacity of SARS-CoV-2 to infect the brain. Using human brain organoids, they observed clear evidence of infection with accompanying metabolic changes in infected and neighboring neurons.
[Journal of Experimental Medicine]
Song, E., Zhang, C., Israelow, B., Lu-Culligan, A., Prado, A. V., Skriabine, S., Lu, P., Weizman, O.-E., Liu, F., Dai, Y., Szigeti-Buck, K., Yasumoto, Y., Wang, G., Castaldi, C., Heltke, J., Ng, E., Wheeler, J., Alfajaro, M. M., Levavasseur, E., … Iwasaki, A. (2021). Neuroinvasion of SARS-CoV-2 in human and mouse brain. Journal of Experimental Medicine, 218(e20202135). https://doi.org/10.1084/jem.20202135 Cite
Full ArticleEditorial
Bookmark

No account yet? Register

0
Share

Single-Cell Chromatin Accessibility Profiling of Glioblastoma Identifies an Invasive Cancer Stem Cell Population Associated with Lower Survival

Researchers showed, using single-cell chromatin accessibility, that primary human glioblastomas (GBMs) harbored a heterogeneous self-renewing population whose diversity was captured in patient-derived GBMs stem cells.
[eLife]
Guilhamon, P., Chesnelong, C., Kushida, M. M., Nikolic, A., Singhal, D., MacLeod, G., Madani Tonekaboni, S. A., Cavalli, F. M., Arlidge, C., Rajakulendran, N., Rastegar, N., Hao, X., Hassam, R., Smith, L. J., Whetstone, H., Coutinho, F. J., Nadorp, B., Ellestad, K. I., Luchman, A. H., … Lupien, M. (2021). Single-cell chromatin accessibility profiling of glioblastoma identifies an Invasive cancer stem cell population associated with lower survival. ELife, 10, e64090. https://doi.org/10.7554/eLife.64090 Cite
Abstract
Bookmark

No account yet? Register

0
Share
Share