APOE2 Mitigates Disease-Related Phenotypes in an Isogenic hiPSC-Based Model of Alzheimer’s Disease

Investigators utilized an isogenic human induced pluripotent stem cell (hiPSC)-based system to demonstrate that conversion of APOE3 to APOE2 greatly reduced the production of amyloid-beta peptides in hiPSC-derived neural cultures.
[Molecular Psychiatry]
Brookhouser, N., Raman, S., Frisch, C., Srinivasan, G., & Brafman, D. A. (2021). APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer’s disease. Molecular Psychiatry, 1–18. https://doi.org/10.1038/s41380-021-01076-3 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Neuroendocrine Control of Appetite and Metabolism

The authors discuss the regulation of appetite and metabolism by hypothalamic neurohormone-expressing cells, with a focus on the distinct contributions of neurohormones and neurotransmitters released by these neurons.
[Experimental & Molecular Medicine]
Yoo, E.-S., Yu, J., & Sohn, J.-W. (2021). Neuroendocrine control of appetite and metabolism. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-021-00597-9 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Astrocytes in Cocaine Addiction and Beyond

Scientists provide a brief overview of the role of astrocytes in regulating synaptic transmission and neuronal function, and discuss how cocaine influences these astrocyte-mediated mechanisms to induce persistent synaptic and circuit alterations that promote cocaine seeking and relapse.
[Molecular Psychiatry]
Wang, J., Holt, L. M., Huang, H. H., Sesack, S. R., Nestler, E. J., & Dong, Y. (2021). Astrocytes in cocaine addiction and beyond. Molecular Psychiatry, 1–17. https://doi.org/10.1038/s41380-021-01080-7 Cite
Abstract
Bookmark

No account yet? Register

0
Share

MrgprC11+ Sensory Neurons Mediate Glabrous Skin Itch

Investigators developed a mouse glabrous skin behavioral assay to investigate the contribution of three previously identified pruriceptive neurons in glabrous skin itch.
[Proceedings of the National Academy of Sciences of the United States of America]
Abstract
Bookmark

No account yet? Register

0
Share

Neural Stem Cells Traffic Functional Mitochondria via Extracellular Vesicles

The authors investigated the hypothesis that neural stem cells release and traffic functional mitochondria via extracellular vesicles to restore mitochondrial function in target cells.
[PLoS Biology]
Peruzzotti-Jametti, L., Bernstock, J. D., Willis, C. M., Manferrari, G., Rogall, R., Fernandez-Vizarra, E., Williamson, J. C., Braga, A., Bosch, A. van den, Leonardi, T., Krzak, G., Kittel, Á., Benincá, C., Vicario, N., Tan, S., Bastos, C., Bicci, I., Iraci, N., Smith, J. A., … Pluchino, S. (2021). Neural stem cells traffic functional mitochondria via extracellular vesicles. PLOS Biology, 19(4), e3001166. https://doi.org/10.1371/journal.pbio.3001166 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Astrocytes and Neurons Share Region-Specific Transcriptional Signatures That Confer Regional Identity to Neuronal Reprogramming

Investigators showed that in the neocortex and thalamus, neurons and astrocytes express shared region-specific transcriptional and epigenetic signatures.
[Science Advances]
Herrero-Navarro, Á., Puche-Aroca, L., Moreno-Juan, V., Sempere-Ferràndez, A., Espinosa, A., Susín, R., Torres-Masjoan, L., Leyva-Díaz, E., Karow, M., Figueres-Oñate, M., López-Mascaraque, L., López-Atalaya, J. P., Berninger, B., & López-Bendito, G. (2021). Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming. Science Advances, 7(15), eabe8978. https://doi.org/10.1126/sciadv.abe8978 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Soluble α-Synuclein–Antibody Complexes Activate the NLRP3 Inflammasome in hiPSC-Derived Microglia

Researchers showed that αSyn activated the NLRP3 inflammasome in human induced pluripotent stem cell (hiPSC)-derived microglia via dual stimulation involving Toll-like receptor 2 engagement and mitochondrial damage.
[Proceedings of the National Academy of Sciences of the United States of America]
Trudler, D., Nazor, K. L., Eisele, Y. S., Grabauskas, T., Dolatabadi, N., Parker, J., Sultan, A., Zhong, Z., Goodwin, M. S., Levites, Y., Golde, T. E., Kelly, J. W., Sierks, M. R., Schork, N. J., Karin, M., Ambasudhan, R., & Lipton, S. A. (2021). Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia. Proceedings of the National Academy of Sciences, 118(15). https://doi.org/10.1073/pnas.2025847118 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Efficient Conversion of Human Induced Pluripotent Stem Cells Into Microglia by Defined Transcription Factors

The authors report a novel approach that produces, within ten days, the differentiation of human induced pluripotent stem cells into microglia by forced expression of both SPI1 and CEBPA.
[Stem Cell Reports]
Chen, S.-W., Hung, Y.-S., Fuh, J.-L., Chen, N.-J., Chu, Y.-S., Chen, S.-C., Fann, M.-J., & Wong, Y.-H. (2021). Efficient conversion of human induced pluripotent stem cells into microglia by defined transcription factors. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.03.010 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Effect of Long-Term 3D Spheroid Culture on WJ-MSC

Investigators developed a protocol enabling a derivation of MSC subpopulation with increased expression of pluripotent and neural genes.
[Cells]
Kaminska, A., Wedzinska, A., Kot, M., & Sarnowska, A. (2021). Effect of Long-Term 3D Spheroid Culture on WJ-MSC. Cells, 10(4), 719. https://doi.org/10.3390/cells10040719 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Identification of an Endogenous Glutamatergic Transmitter System Controlling Excitability and Conductivity of Atrial Cardiomyocytes

Researchers reveal an intrinsic glutamatergic transmitter system directly modulating excitability and conductivity of atrial cardiomyocytes through controlling ionotropic glutamate receptor-gated currents.
[Cell Research]
Xie, D., Xiong, K., Su, X., Wang, G., Ji, Q., Zou, Q., Wang, L., Liu, Y., Liang, D., Xue, J., Wang, L., Gao, X., Gu, X., Liu, H., He, X., Li, L., Yang, J., Lu, Y., Peng, L., & Chen, Y.-H. (2021). Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes. Cell Research, 1–14. https://doi.org/10.1038/s41422-021-00499-5 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Overlapping Roles of JIP3 and JIP4 in Promoting Axonal Transport of Lysosomes in Human iPSC-Derived Neurons

Investigators established a hiPSC-derived neuron model for the investigation of axonal lysosome transport and maturation and showed that loss of JIP3 resulted in the accumulation of axonal lysosomes and the Alzheimer’s disease-related amyloid precursor protein-derived Aβ42 peptide.
[Molecular Biology of the Cell]
Gowrishankar, S., Lyons, L., Rafiq, N. M., Roczniak-Ferguson, A., De Camilli, P., & Ferguson, S. M. (2021). Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons. Molecular Biology of the Cell, mbc.E20-06-0382. https://doi.org/10.1091/mbc.E20-06-0382 Cite
Abstract
Bookmark

No account yet? Register

0
Share
Share