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neural cells

Large-Scale Analysis of MicroRNA Expression in Motor Neuron-Like Cells Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells

[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.

SARM1 Depletion Slows Axon Degeneration in a CNS Model of Neurotropic Viral Infection

[Frontiers in Molecular Neuroscience] Investigators tested the hypothesis that ZIKV-associated degeneration of neuronal processes was dependent on activation of Sterile alpha and armadillo motif-containing protein 1 (SARM1), an NADase that acted as a central executioner in a conserved axon degeneration pathway.

Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma

[Cancer Immunology Research] Scientists showed that circadian locomotor output cycles kaput (CLOCK) and its heterodimeric partner brain and muscle ARNT-like 1 in glioma stem cells drive immunosuppression in glioblastoma.

ISL1 Promotes Human Glioblastoma-Derived Stem Cells Self-Renewal by Activation of SHH/GLI1 Function

[Stem Cells and Development] Researchers established patient derived glioblastoma stem cells (GSCs), determined cancer stem cell marker expression, and immunostained GSCs to assess cell viability and apoptosis.

Phenotypic and Molecular States of IDH1 Mutation-Induced CD24-Positive Glioma Stem-Like Cells

[Neoplasia] The authors demonstrated that induction of a CD24-positive population is one mechanism by which IDH-mutant tumors acquired stem-like properties.

CHMP2A Regulates Tumor Sensitivity to Natural Killer Cell-Mediated Cytotoxicity

[Nature Communications] Scientists used a “two cell type” whole genome CRISPR-Cas9 screening system to discover key regulators of tumor sensitivity and resistance to natural killer cell-mediated cytotoxicity in human glioblastoma stem cells.