induced pluripotent stem cells

[BMC Cardiovascular Disorders] Investigators provide a brief overview of protocols that have laid the foundation for derivation of stem-cell derived 3D cardiac models.

[NPJ Regenerative Medicine] To examine the effects of chronic 4-hydroxytamoxifen treatment, researchers used state-of-the-art human-induced pluripotent stem cell-derived cardiomyocytes and a bioengineered platform to model duchenne muscular dystrophy.

[Stem Cells] Scientists review various modalities to evaluate the function of human stem cell-derived cardiac tissues and introduce heart-on-a-chip systems that can recapitulate physiological parameters of human pluripotent stem cell-derived cardiac tissues.

[Scientific Reports] Scientists characterized non-endocrine cells in iPSC-derived pancreatic islet cells using single-cell transcriptomic analysis and found that non-endocrine cells consisted of heterogeneous proliferating cells, and cells with not only pancreatic traits but also liver or intestinal traits marked by FGB or AGR2.

[Developmental Cell] To better characterize human retinal cis-regulatory elements, investigators performed single-nucleus assay for transposase-accessible chromatin sequencing and single-nucleus RNA sequencing on the developing and adult human retina and on iPSC-derived retinal organoids.

[Frontiers in Cell and Developmental Biology] Researchers described a protocol that can be adopted by those seeking to create clinical-grade iPSC from banked cord blood. Cells were maintained in a feeder-free, xeno-free environment, using fully defined, commercially available reagents.