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influenza

Nasal Symbiont Staphylococcus epidermidis Restricts the Cellular Entry of Influenza Virus into the Nasal Epithelium

[NPJ Biofilms and Microbiomes] Investigators found that human nasal commensal Staphylococcus epidermidis promoted protease–protease inhibitor balance in favor of the host and prevented influenza A virus replication in the nasal mucosa and lungs.

Cocrystal Pharma Reports Favorable Preliminary Data from Phase I Initial Cohorts with CC-42344, a Novel, Broad-Spectrum Influenza A antiviral

[Cocrystal Pharma, Inc.] Cocrystal Pharma, Inc. reported preliminary results of a Phase I study with CC-42344, a broad-spectrum oral antiviral for the treatment of pandemic and seasonal influenza A, demonstrating a favorable safety and pharmacokinetic profile.

SyneuRx Reaches Target Enrollment in Phase 2 Clinical Trial of COVID-19 Oral Antiviral Candidate Pentarlandir® (SNB01)

[SyneuRx™ International] SyneuRx™ International announced it has completed enrollment for its Phase II clinical trial evaluating the efficacy and safety of SNB01 ('Pentarlandir’), a novel COVID-19 oral antiviral candidate.

Human Placental Hematopoietic Stem Cell Derived Natural Killer Cells (CYNK-001) Mediate Protection against Influenza a Viral Infection

[Human Vaccines & Immunotherapeutics] Scientists investigated the effects of CYNK-001, human placental hematopoietic stem cell derived NK cells that exhibited strong cytolytic activity against a range of malignant cells and expressed high levels of activating receptors, against influenza A virus infections.

Elimination of Receptor Binding by Influenza Hemagglutinin Improves Vaccine-Induced Immunity

[NPJ Vaccines] Researchers generated a virus-like particle (VLP) vaccine bearing the hemagglutinin of H1N1 A/California/07/09 that was unable to bind to its α(2,6)-linked sialic acid receptor and compared its immunogenicity and efficacy to a wild-type H1-VLP in mice.

Elimination of Receptor Binding by Influenza Hemagglutinin Improves Vaccine-Induced Immunity

[NPJ Vaccines] Researchers generated a virus-like particle (VLP) vaccine bearing the hemagglutinin of H1N1 A/California/07/09 that was unable to bind to its α(2,6)-linked sialic acid receptor and compared its immunogenicity and efficacy to a wild-type H1-VLP in mice.

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