insulin

[Scientific Reports] In in vitro assessment, released insulin at high glucose stimulation, insulin content, and expressions of vascular endothelial growth factor and integrin β1 were improved in adiponectin-treated islets.

[Molecular Cancer] Hsa_circ_0003258 physically binded to insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) in the cytoplasm and enhanced HDAC4 mRNA stability, in which it activated ERK signaling pathway, then triggered epithelial mesenchymal transformation programming and finally accelerated the metastasis of prostate cancer.

[Cancer Research] Researchers analyzed the expression profiles of circRNAs in docetaxel-resistant and -sensitive prostate cancer cells through RNA sequencing and found that expression of circARHGAP29 was significantly upregulated in docetaxel-resistant cell lines and clinical samples.

[Cell Reports] Scientists showed that Gpr17, an orphan G protein-coupled receptors, was co-expressed in glucagon-like peptide-1 (GLP-1)-expressing EECs in human and rodent intestinal epithelium.

[Advanced Science] Investigators developed a new microfluidic multi-organoid system that recapitulated the human liver-pancreatic islet axis in normal and disease states.

[Weill Cornell Medicine] Weill Cornell Medicine researchers have received a two-year $500,000 grant from JDRF to evaluate an innovative approach to islet cell transplantation, an experimental treatment for difficult-to-control type 1 diabetes.