insulin

[iScience] Although contributing to diet-induced obesity and fatty liver, Suppressors of Cytokine Signaling 3 (SOCS3) was nevertheless critical to suppress excess myeloid hematopoiesis and severe systemic inflammation associated with intestinal dysbiosis on a high-fat diet.

[Journal of Pharmaceutical and Biomedical Analysis] Psoriasis is known to alter the expression of proteins that are involved in the inflammatory and antioxidant response, as well as protein biosynthesis, degradation, as well as cell proliferation and apoptosis.

[Nature Reviews Endocrinology] Scientists summarize the role of autophagy in the pathogenesis of metabolic diseases associated with or occurring in the context of aging, including insulin resistance, type 2 diabetes mellitus and sarcopenic obesity, and describes its potential as a therapeutic target.

[Proceedings of the National Academy of Sciences of the United States of America] The authors showed that convective transport improved nutrient delivery throughout the device and affords a three-dimensional capsule geometry that encapsulates 9.7-fold-more cells than conventional macroencapsulation devices.

[Scientific Reports] The authors investigated the role of microglial chromodomain-helicase DNA-binding protein 8 and tuberous sclerosis complex 2 in cytokine expression, phagocytosis activity, and neuro/gliogenesis from neural stem cells in vitro.

[Nature Metabolism] FA2H was a direct target of miR-3075 and small interfering RNA depletion of FA2H in adipocytes, myocytes and primary hepatocytes led to increased insulin sensitivity. In chronic obesity, hepatocyte exosomes promoted a state of insulin resistance.