insulin

[Cell Stem Cell] Lineage tracing using the Neurogenin3 (Ngn3)-CreERT line identified ductal cells expressing the endocrine master transcription factor Ngn3 that were positive for the δ cell marker somatostatin and occasionally co-expressed insulin.

[Fractyl Health, Inc.] Fractyl Health, Inc. announced the activation of the tenth clinical site in the company’s pivotal REVITA-T2Di trial taking place across the US and Europe.

[Metabolism-Clinical and Experimental] β cells in the hyperglycemic environment of diabetes have marked changes in phenotype and function that are largely reversible if glucose levels can be returned to normal. A leading hypothesis is that these changes are caused by the elevated glucose levels leading to the concept of glucose toxicity.

[Lancet Diabetes & Endocrinology] The authors discuss the potential regenerative capacity of the remaining islet cells and the utility of stem cell-derived β-like cells to restore β-cell function and describe tissue engineering approaches that might improve the engraftment, function, and survival of β-cell replacement therapies.

[Biochemical Pharmacology] The authors investigated the intracellular signaling pathway following stimulation of Cav1.2 Ca2+ channels and addressed the function of the transcription factor activator protein-1 in pancreatic β-cells of transgenic mice.

[Cell Reports] Scientists investigated the effect of early-life antibiotic exposure on otherwise healthy, normal chow-fed, wild-type mice, monitoring these mice for more than 700 days in comparison with untreated control mice.