intestinal cells

[Biology Open] Using the Drosophila midgut as a model, researchers have recently described that adult intestinal stem cells, do not activate programmed cell death upon aneuploidy induction, leading to an increase in ISC proliferation rate, and tissue dysplasia. 

[Stem Cell Reports] The authors showed that the septate junction protein Neuroglian was expressed in intestinal stem cells and enteroblasts within the fly intestine.

[Molecular Cell] Disruption of the ZMYND8-dependent MVA pathway greatly restricted the self-renewal capacity of Lgr5+ intestinal stem cells and intestinal tumorigenesis.

[International Journal of Biological Macromolecules] Researchers showed that SEPS increased the proliferation and survival of intestinal epithelial cells during dextran sulfate sodium stimulation.

[Stem Cell Reports] Myh9 deletion disturbs cell junctions and impairs intestinal lumen barrier integrity, promoting the necroptosis of epithelial cells.

[Autophagy] Investigators review the physiological role of autophagy in the context of intestinal epithelial maintenance and how genetic mutations affecting autophagy contribute to the development of intestinal disease.