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intestinal epithelial cells

GATA6 Deficiency Leads to Epithelial Barrier Dysfunction and Enhances Susceptibility to Gut Inflammation

[Journal of Crohn's and Colitis] Expression of GATA-binding factor 6 (GATA6), a transcription factor involved in intestinal epithelial cell differentiation, was evaluated in colon samples taken from healthy controls and IBD patients by real-time PCR and immunohistochemistry.

PRKAR2A Deficiency Protects Mice from Experimental Colitis by Increasing IFN-Stimulated Gene Expression and Modulating the Intestinal Microbiota

[Mucosal Immunology] Scientists investigated the role of the protein kinase A regulatory subunit PRKAR2A in colitis and observed that PRKAR2A deficiency protected mice from dextran sulfate sodium-induced experimental colitis and that the intestinal epithelial cell-specific deletion of Prkar2a contributed to this protection.

Toxic Effects of Fluoride in Intestinal Epithelial Cells and the Mitigating Effect of Methanol Extract of Coconut Haustorium by Enhancing De Novo Glutathione Biosynthesis

[Environmental Research] The possible use of an emerging functional food-the coconut haustorium was evaluated against sodium fluoride-induced toxicity in intestinal cells. The cells exposed to fluoride showed significant cell death mediated through the increased lipid peroxidation and glutathione depletion.

Single-Cell Transcriptomics Reveals Immune Response of Intestinal Cell Types to Viral Infection

[EMBO Reports] Investigators developed a framework combining single-cell RNA-Seq and highly multiplex RNA FISH and applied it to human intestinal organoids infected with human astrovirus, a model human enteric virus.

Foxo1 Controls Gut Homeostasis and Commensalism by Regulating Mucus Secretion

[Journal of Experimental Medicine] Researchers identified that Forkhead box protein O1 (Foxo1) regulates mucus secretion by goblet cells and determines intestinal homeostasis. Loss of Foxo1 in intestinal epithelial cells resulted in defects in goblet cell autophagy and mucus secretion, leading to an impaired gut microenvironment and dysbiosis.

Overexpression of miR-122 Impairs Intestinal Barrier Function and Aggravates Acute Pancreatitis by Downregulating Occludin Expression

[Biochemical Genetics] The authors studied the mechanism of miR-122 in regulating intestinal barrier function in acute pancreatitis (AP). AP rat model was constructed via intraperitoneal injection of ketamine, and primary intestinal epithelial cells were isolated from rats for in vitro studies.

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