ERK/MAPK Signaling Is Essential for Intestinal Development through Wnt Pathway Modulation

Scientists found that deletion of Erk1/2 in intestinal epithelial cells at embryonic stages resulted in an unexpected increase in cell proliferation and migration, expansion of intestinal stem cells and formation of polyp-like structures, leading to postnatal death.
[Development]
ERK/MAPK signaling is essential for intestinal development through Wnt pathway modulation | Development. (n.d.). Retrieved August 7, 2020, from https://dev.biologists.org/content/early/2020/07/30/dev.185678 Cite
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Cycling Stem Cells Are Radioresistant and Regenerate the Intestine

The authors demonstrate that the DNA damage-resistant Msi1+ cells are cycling intestinal stem cells that maintain and regenerate the intestinal epithelium.
[Cell Reports]
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LIF Is Essential for ISC Function and Protects against Radiation-Induced Gastrointestinal Syndrome

Leukemia inhibitory factor (LIF) is a cytokine essential for maintaining pluripotency of mouse ESCs. Scientists found that LIF was present in the intestinal stem cell (ISC) niche in crypts and critical for the function of ISCs in maintaining the intestinal epithelial homeostasis and regeneration.
[Cell Death & Disease]
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The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer

Investigators demonstrated essential roles of ubiquitin-specific protease 25 in experimental colitis, bacterial infections and colon cancer.
[Nature Cancer]
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TIGAR/AP-1 axis accelerates the division of Lgr5− reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation

Researchers demonstrated that post-ionizing radiation overexpression of TIGAR, a critical downstream target of c-MYC in mouse intestine, mounted a hyperplastic response in Bmi1-creERT+ reserve ISCs, and thus rescued mice from lethal ionizing radiation exposure.
[Cell Death & Disease]
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Fitness Trade-Offs Incurred by Ovary-To-Gut Steroid Signalling in Drosophila

Scientists report that steroid signalling in drosophila from ovaries to gut promoted growth of the intestine specifically in mated females, and enhances their reproductive output.
[Nature]
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Lipoic Acid Rejuvenates Aged Intestinal Stem Cells by Preventing Age‐Associated Endosome Reduction

This study reports that alpha‐lipoic acid reversed age‐associated intestinal stem cell dysfunction by promoting the activation of the endocytosis–autophagy network, which was decreased in aged intestinal stem cells.
[EMBO Reports]
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Glucagon like Peptide-2 for Intestinal Stem Cell and Paneth Cell Repair during Graft-Versus-Host Disease in Mice and Humans

Investigators found that L-cells were a target of acute graft-versus-host disease (GVHD) and that glucagon-like-peptide-2-based treatment of acute GVHD restored intestinal homeostasis via an increase of intestinal stem cells and paneth cells without impairing graft-versus-leukemia effects.
[Blood]
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The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells from Their Niche and Differentiation into Enterocyte vs Secretory Lineages

Scientists analyzed Notch regulation by examining expression profiles of small intestinal organoids incubated with the Notch inhibitor DAPT, intestine tissues from mice given injections of the γ-secretase inhibitor dibenzazepine, and mice with intestine-specific disruption of Rbpj.
[Gastroenterology]
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Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

Researchers studied the role of bile acids and G protein-coupled bile acid receptor 1 (TGR5) in intestinal renewal, and regulation of intestinal stem cell function in mice and intestinal organoids.
[Gastroenterology]
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