Canonical TGFβ Signaling Induces Collective Invasion in Colorectal Carcinogenesis through a Snail1- and Zeb1-Independent Partial EMT

The authors investigated the impact of oncogenic transformation and the microenvironment on tumor cell invasion using genetically engineered organoids as colorectal cancer models.
[Oncogene]
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An In Vitro Chronic Damage Model Impairs Inflammatory and Regenerative Responses in Human Colonoid Monolayers

Investigators developed a chronic-injury model in human colonoid monolayers by repeated rounds of air-liquid interface and submerged culture.
[Cell Reports]
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CDC42 Controlled Apical-Basal Polarity Regulates Intestinal Stem Cell to Transit Amplifying Cell Fate Transition via YAP-EGF-mTOR Signaling

The authors found that CDC42 loss initiated in the intestinal stem cell caused a drastic hyperproliferation of transit amplifying cells and disrupted epithelial polarity.
[Cell Reports]
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Robust Differentiation of Human Enteroendocrine Cells from Intestinal Stem Cells

Investigator employed small molecule targeting of the endocannabinoid receptor signaling pathway, JNK, and FOXO1, known to mediate endodermal development and/or hormone production, together with directed differentiation of human ISCs from the duodenum and rectum.
[Nature Communications]
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ID2 Controls Differentiation of Enteroendocrine Cells in Mouse Small Intestine

To assess the functions of ID2 in the adult mouse small intestine, investigators used single-cell RNA sequencing, genetically modified mice, and organoid assays.
[Acta Physiologica]
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Ionizing Radiation Alters Organoid Forming Potential and Replenishment Rate in a Dose/Dose-Rate Dependent Manner

Researchers assessed the response to radiation dose and dose-rate by measuring both organoid-forming potential and the percentage of stem cells in the crypts.
[Journal of Radiation Research]
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MLL1 Is Required for Maintenance of Intestinal Stem Cells

Loss of mixed lineage leukemia 1 (MLL1) was accompanied by loss of intestinal stem cells and a differentiation bias towards the secretory lineage with increased numbers and enlargement of goblet cells.
[PLoS Genetics]
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Smooth Muscle-Specific MMP17 (MT4-MMP) Regulates the Intestinal Stem Cell Niche and Regeneration after Damage

Scientists showed that smooth muscle cells might be the dominant suppliers of BMP antagonists, which are niche factors essential for intestinal stem cell maintenance.
[Nature Communications]
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Synthetic Dynamic Hydrogels Promote Degradation-Independent In Vitro Organogenesis

Investigators reported a family of synthetic hydrogels that promoted extensive organoid morphogenesis through dynamic rearrangements mediated by reversible hydrogen bonding.
[Nature Materials]
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Loss of Aryl Hydrocarbon Receptor Suppresses the Response of Colonic Epithelial Cells to IL22 Signaling by Upregulating SOCS3

Scientists showed that IL22 treatment induced the phosphorylation of STAT3, inhibited colonic organoid growth, and promoted colonic cell proliferation in vivo.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
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Enteric Glial Cell Heterogeneity Regulates Intestinal Stem Cell Niches

Scientists defined the regulation of enteric glial cells heterogeneity in homeostasis and chronic inflammatory bowel disease.
[Cell Stem Cell]
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