intestinal stem cells

[Stem Cell Reports] Using single-cell transcriptomics, investigators observed that OLFM4, a NOTCH target gene present in intestinal stem cells, was first expressed at 13 weeks post-conception in the developing human intestine and increased over time.

[Toxicology Letters] Small intestinal organoids were used to assess if arsenic exposure would also impair intestinal stem cell differentiation. No changes in markers of differentiated epithelial cells were seen.

[Nature Biomedical Engineering] The authors showed that druggable biological targets and small-molecule regulators of intestinal stem cell differentiation could be identified via multiplexed phenotypic screening using thousands of miniaturized organoid models of intestinal stem cell differentiation into Paneth cells.

[Stem Cell Reviews and Reports] The authors describe the effects of various immune cells on intestinal stem cells (ISCs), as well as the mechanisms underlying these effects and also highlight the remarkable role of ISCs in intestinal pathogenesis.

[Cell Research] The authors demonstrated that Lepr+ MSCs surrounding intestinal crypts sensed diet change and provided a novel niche signal to maintain intestinal stem cell and progenitor cell proliferation.

[Molecular Nutrition & Food Research] Intestinal organoids and mice were used to explore the effects of milk-derived small extracellular vesicles on intestinal regeneration.