Researchers showed that a recently identified autophagy enhancer (MSL-7) reduces human IAPP oligomer accumulation in human iPSC-derived β-cells and diminishes oligomer-mediated apoptosis of β-cells.
[Nature Communications]
Kim, J., Park, K., Kim, M. J., Lim, H., Kim, K. H., Kim, S.-W., Lee, E.-S., Kim, H. (Henry), Kim, S. J., Hur, K. Y., Kim, J. H., Ahn, J. H., Yoon, K.-H., Kim, J.-W., & Lee, M.-S. (2021). An autophagy enhancer ameliorates diabetes of human IAPP -transgenic mice through clearance of amyloidogenic oligomer. Nature Communications, 12(1), 183. https://doi.org/10.1038/s41467-020-20454-z Cite
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